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Query: EPHA2

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EPHA2 0 0.885 1.330 -0.460 0.221

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EPHA2 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
EPHA2 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHA2 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHA2 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHA2 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHA2 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_

Background Information for EPHA2:


Pubmed-EPHA2 »
Uniprot-EPHA2 »
Biogrid-EPHA2 »
ProteomicsDB-EPHA2 »

Tumorportal-EPHA2 »
COSMIC-EPHA2 »
GenomeRNAi-EPHA2 »
Genecards-EPHA2


Protein-protein Interactions for EPHA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EPHA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1orf88 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CIR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GJB7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRIQ1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCSTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NTRK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC25A41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TARDBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM185A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EPHA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Fibronectin_type3 IPR003961 0.19
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ephrin_rcpt_lig-bd_dom IPR001090 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members SAM IPR001660 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Galactose-bd-like IPR008979 0
Category members Growth_fac_rcpt_N_dom IPR009030 0
Category members SAM_2 IPR011510 0
Category members SAM/pointed IPR013761 0
Category members Interferon_alpha/beta_rcpt_bsu IPR015373 0
Category members Tyr_kinase_ephrin_rcpt IPR016257 0
Category members Tyr_kinase_cat_dom IPR020635 0
Category members SAM_type1 IPR021129 0


Protein complexes (CORUM database) featuring EPHA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5190 TIAM1-EFNB1-EPHA2 complex Database 0


Categories featuring EPHA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_466 PID_ECADHERIN_STABILIZATION_PATHWAY 0 1.4
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members Pathway Pathway_992 PID_ARF6_PATHWAY 0 0.46
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members GO Category GO:0010591 regulation of lamellipodium assembly Database 0.31
Category members GO Category GO:0045765 regulation of angiogenesis Database 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0031258 lamellipodium membrane Database 0.15
Category members GO Category GO:0033598 mammary gland epithelial cell proliferation Database 0.09
Category members Pathway Pathway_511 PID_EPHA2_FWD_PATHWAY 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members GO Category GO:0021915 neural tube development Database 0.03
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_665 PID_EPHA_FWDPATHWAY 0 0.01
Category members Disease phenotype Posterior_polar_cataract Posterior polar cataract Database 0
Category members Disease phenotype Total_congenital_cataract Total congenital cataract Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001570 vasculogenesis Database 0
Category members GO Category GO:0001649 osteoblast differentiation Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0005003 ephrin receptor activity Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway Database 0
Category members GO Category GO:0014028 notochord formation Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0030316 osteoclast differentiation Database 0
Category members GO Category GO:0031256 leading edge membrane Database 0
Category members GO Category GO:0032863 activation of Rac GTPase activity Database 0
Category members GO Category GO:0033628 regulation of cell adhesion mediated by integrin Database 0
Category members GO Category GO:0036342 post-anal tail morphogenesis Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0
Category members GO Category GO:0043535 regulation of blood vessel endothelial cell migration Database 0
Category members GO Category GO:0046849 bone remodeling Database 0
Category members GO Category GO:0048013 ephrin receptor signaling pathway Database 0
Category members GO Category GO:0048570 notochord morphogenesis Database 0
Category members GO Category GO:0051898 negative regulation of protein kinase B signaling Database 0
Category members GO Category GO:0060326 cell chemotaxis Database 0
Category members GO Category GO:0060444 branching involved in mammary gland duct morphogenesis Database 0
Category members GO Category GO:0070309 lens fiber cell morphogenesis Database 0
Category members GO Category GO:0070372 regulation of ERK1 and ERK2 cascade Database 0
Category members GO Category GO:0070848 response to growth factor Database 0


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