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negative regulation of protein kinase B signaling
(GO:0051898)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
TSC2 1 0.810 -0.710
TSC2 1 0.810 -0.710 -0.715
IGF1R 1 -0.490 0.750 1.476 0.714
GNB2L1 1 1.000 -0.100 0.279 1.704
GNB2L1 1 1.000 -0.100 -0.278 -0.107 -0.424
SIRT1 0 0.910 -0.910
PLEKHA1 0 -0.130 0.730
PLEKHA1 0 -0.130 0.730
PLEKHA1 0 -0.130 0.730
SLC9A3R1 0 0.240 -0.810
INPP5K 0 -0.690 1.160
EPHA2 0 1.330 -0.460 0.221
FLCN 0 1.070 -0.810
DAG1 0 0.210 -0.400
PHLDA3 0 -1.120 1.360
PDCD6 0 -1.230 2.040 -0.156 -0.537 0.910 -0.243 -0.371

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
DAG1 Ubiquitylation K793 0.843 _LTLEDQATFIK(gl)K_
DAG1 Ubiquitylation K794 0.899 _LTLEDQATFIKK(gl)_
DAG1 Ubiquitylation K881 -0.342 _GSRPK(gl)NMTPYR_
EPHA2 Ubiquitylation K578 -0.752 -0.618 _QSPEDVYFSK(gl)SEQLKPLK_
EPHA2 Ubiquitylation K583 0.445 0.124 _SEQLK(gl)PLK_
EPHA2 Ubiquitylation K617 0.339 _QK(gl)VIGAGEFGEVYK_
EPHA2 Ubiquitylation K649 -1.219 _TLK(gl)AGYTEK_
EPHA2 Phosphorylation S897 0.000 _LPS(ph)TSGSEGVPFR_
EPHA2 Phosphorylation T898 -0.329 0.424 _LPST(ph)SGSEGVPFR_
FLCN Phosphorylation S62 -0.873 -0.905 _AHS(ph)PAEGASVESSSPGPK_
GNB2L1 Ubiquitylation K38 -0.238 0.350 _DK(gl)TIIMWK_
GNB2L1 Ubiquitylation K106 -0.290 _RFVGHTK(gl)DVLSVAFSSDNR_
GNB2L1 Ubiquitylation K130 0.632 _TIK(gl)LWNTLGVCK_
GNB2L1 Ubiquitylation K175 -0.554 -0.015 _LVK(gl)VWNLANCK_
GNB2L1 Ubiquitylation K183 -0.161 -0.282 _VWNLANCK(gl)_
GNB2L1 Ubiquitylation K185 -0.061 -0.249 _VWNLANCKLK(gl)_
GNB2L1 Ubiquitylation K257 -0.288 _YWLCAATGPSIK(gl)_
GNB2L1 Ubiquitylation K271 0.756 -0.007 _IIVDELK(gl)QEVISTSSK_
IGF1R Ubiquitylation K47 1.146 _NDYQQLK(gl)R_
IGF1R Ubiquitylation K1033 5.779 _VAIK(gl)TVNEAASMR_
IGF1R Ubiquitylation K1168 0.191 _K(gl)GGKGLLPVR_
IGF1R Ubiquitylation K1171 0.232 _GGK(gl)GLLPVR_
INPP5K Ubiquitylation K248 -0.741 0.167 _LLFPPTYK(gl)FDR_
PDCD6 Ubiquitylation K112 0.803 -0.435 _TYDRDNSGMIDK(gl)NELK_
PHLDA3 Ubiquitylation K158 -0.201 0.733 _EGVLEK(gl)R_
PLEKHA1 Ubiquitylation K229 -0.332 _SELEK(gl)EPLR_
PLEKHA1 Phosphorylation S308 0.664 0.154 _RLS(ph)NPCIQR_
PLEKHA1 Phosphorylation S332 0.540 _SNS(ph)LVSTFTM(ox)EK_
SIRT1 Phosphorylation S14 -0.369 -0.246 _(ac)ADEAALALQPGGS(ph)PSAAGADR_
SIRT1 Phosphorylation S16 -0.306 -1.665 _(ac)ADEAALALQPGGS(ph)PS(ph)AAGADREAASSPAGEPLR_
SIRT1 Phosphorylation S26 -1.047 -0.245 _EAAS(ph)SPAGEPLR_
SIRT1 Phosphorylation S27 0.351 -0.363 _EAASS(ph)PAGEPLR_
SIRT1 Phosphorylation S47 -0.574 -0.607 _S(ph)PGEPGGAAPER_
SIRT1 Ubiquitylation K238 -1.641 _RK(gl)DINTIEDAVK_
SIRT1 Ubiquitylation K499 -2.138 -0.204 _LGGEYAK(gl)LCCNPVK_
SIRT1 Ubiquitylation K578 -2.782 _GCMEEK(gl)PQEVQTSR_
SIRT1 Ubiquitylation K601 -3.051 _NVESIAEQMENPDLK(gl)NVGSSTGEK_
SLC9A3R1 Ubiquitylation K50 -1.732 _LVEPGSPAEK(gl)AGLLAGDR_
SLC9A3R1 Ubiquitylation K101 -2.049 _LLVVDPETDEQLQK(gl)LGVQVR_
SLC9A3R1 Phosphorylation S280 -0.611 -0.277 _EALAEAALES(ph)PRPALVR_
SLC9A3R1 Phosphorylation S290 -0.404 -0.401 _SAS(ph)SDTSEELNSQDSPPK_
TSC2 Ubiquitylation K3 -1.397 _(ac)AK(gl)PTSKDSGLK_
TSC2 Ubiquitylation K14 -1.297 _DSGLKEK(gl)FK_
TSC2 Ubiquitylation K69 0.051 _MIGQICEVAK(gl)TK_
TSC2 Ubiquitylation K71 -0.157 _MIGQICEVAKTK(gl)_
TSC2 Ubiquitylation K258 -0.278 _ELCEPCWK(gl)LMR_
TSC2 Ubiquitylation K634 1.610 _LGLPNK(gl)DGVVR_
TSC2 Phosphorylation S950 -0.152 -0.529 _STS(ph)LNERPK_
TSC2 Phosphorylation S1064 -0.927 _SLLGLDSGELQSGPESSSS(ph)PGVHVR_
TSC2 Phosphorylation S1248 -0.604 _SNTDSAVVMEEGS(ph)PGEVPVLVEPPGLEDVEAALGMDRR_
TSC2 Phosphorylation S1329 -0.120 _S(ph)SSSPELQTLQDILGDPGDK_
TSC2 Phosphorylation S1331 -0.262 _SSS(ph)SPELQTLQDILGDPGDKADVGR_
TSC2 Phosphorylation S1332 -0.063 _SSSS(ph)PELQTLQDILGDPGDK_
TSC2 Phosphorylation S1355 0.174 0.351 _ADVGRLS(ph)PEVK_
TSC2 Phosphorylation S1362 0.859 _S(ph)QSGTLDGESAAWSASGEDSR_
TSC2 Phosphorylation S1364 0.522 0.550 _SQS(ph)GTLDGESAAWSASGEDSR_
TSC2 Phosphorylation T1366 0.137 _SQSGT(ph)LDGESAAWSASGEDSR_
TSC2 Phosphorylation S1396 0.498 _S(ph)PSGLRPR_
TSC2 Phosphorylation S1743 0.596 _RLISS(ph)VEDFTEFV_


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