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Query: SIRT1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIRT1 0 -1.739 0.910 -0.910

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIRT1 Ubiquitylation K499 -2.138 -0.204 _LGGEYAK(gl)LCCNPVK_
SIRT1 Phosphorylation S26 -1.047 -0.245 _EAAS(ph)SPAGEPLR_
SIRT1 Phosphorylation S14 -0.369 -0.246 _(ac)ADEAALALQPGGS(ph)PSAAGADR_
SIRT1 Phosphorylation S27 0.351 -0.363 _EAASS(ph)PAGEPLR_
SIRT1 Phosphorylation S47 -0.574 -0.607 _S(ph)PGEPGGAAPER_
SIRT1 Phosphorylation S16 -0.306 -1.665 _(ac)ADEAALALQPGGS(ph)PS(ph)AAGADREAASSPAGEPLR_
SIRT1 Ubiquitylation K238 -1.641 _RK(gl)DINTIEDAVK_
SIRT1 Ubiquitylation K578 -2.782 _GCMEEK(gl)PQEVQTSR_
SIRT1 Ubiquitylation K601 -3.051 _NVESIAEQMENPDLK(gl)NVGSSTGEK_

Background Information for SIRT1:


Pubmed-SIRT1 »
Uniprot-SIRT1 »
Biogrid-SIRT1 »
ProteomicsDB-SIRT1 »

Tumorportal-SIRT1 »
COSMIC-SIRT1 »
GenomeRNAi-SIRT1 »
Genecards-SIRT1


Protein-protein Interactions for SIRT1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DTL Cat. description Hein, Mann, Cell 2015
Category members IP bait ESRRB Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXO7 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPA1L2 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRPPRC Cat. description Hein, Mann, Cell 2015
Category members IP bait MAX Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait UFL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AKR1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APEX2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CERKL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CWC15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM54A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HOXB5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBFA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SFRP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SOST Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TADA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBCCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNNI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWA3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB38 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF263 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF354C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF550 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF669 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF707 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIRT1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Sirtuin IPR003000 0
Category members Ssirtuin_cat_dom IPR026590 0
Category members DHS-like_NAD/FAD-binding_dom IPR029035 0


Protein complexes (CORUM database) featuring SIRT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2821 hSIR2-p53 complex Database 0.33
Category members Corum 1177 Polycomb repressive complex 4 (PRC4) Database 0
Category members Corum 2590 FOXO1-FHL2-SIRT1 complex Database 0
Category members Corum 2593 FOXO3-SIRT1 complex, oxidative stress stimulated Database 0


Categories featuring SIRT1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0005637 nuclear inner membrane Database 1.98
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0005720 nuclear heterochromatin Database 1.41
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0033158 regulation of protein import into nucleus, translocation Database 1.32
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members GO Category GO:0042393 histone binding Database 0.94
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0006642 triglyceride mobilization Database 0.66
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0042326 negative regulation of phosphorylation Database 0.5
Category members GO Category GO:0035098 ESC/E(Z) complex Database 0.47
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0060766 negative regulation of androgen receptor signaling pathway Database 0.35
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members GO Category GO:0032007 negative regulation of TOR signaling Database 0.33
Category members GO Category GO:0006346 methylation-dependent chromatin silencing Database 0.3
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0045348 positive regulation of MHC class II biosynthetic process Database 0.24
Category members GO Category GO:0000183 chromatin silencing at rDNA Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0001934 positive regulation of protein phosphorylation Database 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0010906 regulation of glucose metabolic process Database 0.2
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0005719 nuclear euchromatin Database 0.15
Category members GO Category GO:0055089 fatty acid homeostasis Database 0.14
Category members GO Category GO:0045599 negative regulation of fat cell differentiation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051019 mitogen-activated protein kinase binding Database 0.13
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0051097 negative regulation of helicase activity Database 0.1
Category members GO Category GO:0070403 NAD+ binding Database 0.09
Category members GO Category GO:0016239 positive regulation of macroautophagy Database 0.09
Category members GO Category GO:0046628 positive regulation of insulin receptor signaling pathway Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Pathway Pathway_1062 BIOCARTA_PML_PATHWAY 0 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0032088 negative regulation of NF-kappaB transcription factor activity Database 0.04
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0009267 cellular response to starvation Database 0.03
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0000720 pyrimidine dimer repair by nucleotide-excision repair Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members GO Category GO:0000012 single strand break repair Database 0
Category members GO Category GO:0000731 DNA synthesis involved in DNA repair Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001542 ovulation from ovarian follicle Database 0
Category members GO Category GO:0001678 cellular glucose homeostasis Database 0
Category members GO Category GO:0002821 positive regulation of adaptive immune response Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0004407 histone deacetylase activity Database 0
Category members GO Category GO:0005677 chromatin silencing complex Database 0
Category members GO Category GO:0006342 chromatin silencing Database 0
Category members GO Category GO:0006344 maintenance of chromatin silencing Database 0
Category members GO Category GO:0006476 protein deacetylation Database 0
Category members GO Category GO:0006979 response to oxidative stress Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007346 regulation of mitotic cell cycle Database 0
Category members GO Category GO:0007517 muscle organ development Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0010875 positive regulation of cholesterol efflux Database 0
Category members GO Category GO:0016575 histone deacetylation Database 0
Category members GO Category GO:0017136 NAD-dependent histone deacetylase activity Database 0
Category members GO Category GO:0018394 peptidyl-lysine acetylation Database 0
Category members GO Category GO:0019213 deacetylase activity Database 0
Category members GO Category GO:0031648 protein destabilization Database 0
Category members GO Category GO:0031667 response to nutrient levels Database 0
Category members GO Category GO:0031937 positive regulation of chromatin silencing Database 0
Category members GO Category GO:0032071 regulation of endodeoxyribonuclease activity Database 0
Category members GO Category GO:0032868 response to insulin Database 0
Category members GO Category GO:0033553 rDNA heterochromatin Database 0
Category members GO Category GO:0033558 protein deacetylase activity Database 0
Category members GO Category GO:0034391 regulation of smooth muscle cell apoptotic process Database 0
Category members GO Category GO:0034979 NAD-dependent protein deacetylase activity Database 0
Category members GO Category GO:0034983 peptidyl-lysine deacetylation Database 0
Category members GO Category GO:0035356 cellular triglyceride homeostasis Database 0
Category members GO Category GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway Database 0
Category members GO Category GO:0042632 cholesterol homeostasis Database 0
Category members GO Category GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0043398 HLH domain binding Database 0
Category members GO Category GO:0043425 bHLH transcription factor binding Database 0
Category members GO Category GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) Database 0
Category members GO Category GO:0050872 white fat cell differentiation Database 0
Category members GO Category GO:0051898 negative regulation of protein kinase B signaling Database 0
Category members GO Category GO:0070857 regulation of bile acid biosynthetic process Database 0
Category members GO Category GO:0070932 histone H3 deacetylation Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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