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Results for the Category
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
(GO:0042771)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
USP28 2 1.150 -0.550
MSH2 1 -0.130 0.010 0.224 0.457 0.838 0.840 0.366
SNW1 1 -2.350 4.480
SNW1 1 -2.350 4.480 -0.520 -1.264 -0.234 -2.391 -0.788
PML 1 -0.420 0.350 -0.244 0.322
AEN 1 2.220 -1.070
HIPK2 0 -0.990 0.680
PPP2R5C 0 0.790 -0.490
PPP2R5C 0 0.790 -0.490 -0.455 -0.019
CDIP1 0 1.200 -0.830
SIRT1 0 0.910 -0.910
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
TMEM109 0 1.100 -0.740 -0.686 0.258 -1.625 -0.139 -0.225
CDKN1A 0 1.080 -0.750
TP53 0 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497
PMAIP1 0 0.570 -0.670
HIPK1 0 1.760 -0.820
IFI16 0 0.400 -0.680 0.620 0.590
DDIT4 0 0.750 -0.520
PHLDA3 0 -1.120 1.360
RPS27L 0 0.340 -0.190 0.820 -0.329 -0.404
TOPORS 0 0.090 -0.190

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AEN Ubiquitylation K109 -1.520 _ASGPLPSK(gl)CVAIDCEMVGTGPR_
CDIP1 Ubiquitylation K205 -0.515 0.484 _AYIYTYK(gl)R_
CDKN1A Ubiquitylation K188 -2.505 -1.077 _QTSMTDFYHSK(gl)R_
DDIT4 Ubiquitylation K129 -0.435 -0.920 _LLM(ox)PSQLVSQVGK(gl)ELLR_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
HIPK1 Ubiquitylation K492 -0.060 _YISQTQGLPAEYLLSAGTK(gl)TTR_
HIPK1 Ubiquitylation K614 -0.350 _SCFQNMEICK(gl)R_
HIPK1 Phosphorylation S1271 -0.186 _GSTIYTGYPLS(ph)PTK_
HIPK2 Ubiquitylation K492 -0.060 _YISQTQGLPAEYLLSAGTK(gl)TTR_
HIPK2 Ubiquitylation K614 -0.350 _SCFQNMEICK(gl)R_
MSH2 Ubiquitylation K212 -0.233 _ECVLPGGETAGDMGK(gl)LR_
MSH2 Ubiquitylation K249 0.461 _K(gl)GEQMNSAVLPEMENQVAVSSLSAVIK_
MSH2 Ubiquitylation K347 2.867 _LVNQWIK(gl)QPLMDK_
MSH2 Ubiquitylation K531 1.040 _VTCKEEK(gl)VLR_
MSH2 Ubiquitylation K555 0.164 _FTNSK(gl)LTSLNEEYTK_
MSH2 Ubiquitylation K635 -0.376 _IILK(gl)ASR_
PHLDA3 Ubiquitylation K158 -0.201 0.733 _EGVLEK(gl)R_
PMAIP1 Ubiquitylation K35 -1.475 0.286 _RFGDK(gl)LNFR_
PMAIP1 Ubiquitylation K41 -1.597 0.340 _QK(gl)LLNLISK_
PMAIP1 Ubiquitylation K48 -2.007 -0.586 _LLNLISK(gl)_
PML Ubiquitylation K394 0.515 0.360 _LQDLSSCITQGK(gl)DAAVSKK_
PML Phosphorylation S403 3.141 _KAS(ph)PEAASTPRDPIDVDLPEEAER_
PML Ubiquitylation K476 -0.403 -0.735 _GPSYGEDVSNTTTAQK(gl)R_
PML Phosphorylation S504 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S505 -0.198 -0.109 _S(ph)SPEQPRPSTSK_
PML Phosphorylation S518 -1.632 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S527 -1.392 -1.605 _AVS(ph)PPHLDGPPS(ph)PR_
PML Phosphorylation S530 0.466 0.093 _S(ph)PVIGSEVFLPNSNHVASGAGEAEER_
PML Ubiquitylation K623 -0.784 _IDNETQK(gl)ISQLAAVNR_
PPP2R5C Ubiquitylation K232 -0.302 _FLESPDFQPNIAK(gl)K_
PPP2R5C Ubiquitylation K233 -0.302 0.665 _FLESPDFQPNIAKK(gl)_
PPP2R5C Ubiquitylation K409 -0.010 _QLAK(gl)CVSSPHFQVAER_
RPS27L Ubiquitylation K34 -0.620 _DLLHPSLEEEKKK(gl)_
SIRT1 Phosphorylation S14 -0.369 -0.246 _(ac)ADEAALALQPGGS(ph)PSAAGADR_
SIRT1 Phosphorylation S16 -0.306 -1.665 _(ac)ADEAALALQPGGS(ph)PS(ph)AAGADREAASSPAGEPLR_
SIRT1 Phosphorylation S26 -1.047 -0.245 _EAAS(ph)SPAGEPLR_
SIRT1 Phosphorylation S27 0.351 -0.363 _EAASS(ph)PAGEPLR_
SIRT1 Phosphorylation S47 -0.574 -0.607 _S(ph)PGEPGGAAPER_
SIRT1 Ubiquitylation K238 -1.641 _RK(gl)DINTIEDAVK_
SIRT1 Ubiquitylation K499 -2.138 -0.204 _LGGEYAK(gl)LCCNPVK_
SIRT1 Ubiquitylation K578 -2.782 _GCMEEK(gl)PQEVQTSR_
SIRT1 Ubiquitylation K601 -3.051 _NVESIAEQMENPDLK(gl)NVGSSTGEK_
SNW1 Ubiquitylation K193 1.500 _YTPSQQGVAFNSGAK(gl)QR_
SNW1 Phosphorylation S224 -0.528 0.034 _GPPS(ph)PPAPVMHSPS(ph)RK_
SNW1 Phosphorylation S232 -1.645 -1.722 _GPPS(ph)PPAPVMHS(ph)PSR_
SNW1 Phosphorylation S234 -1.881 _GPPS(ph)PPAPVMHSPS(ph)RK_
TMEM109 Ubiquitylation K46 -1.303 -0.093 _RDFAPPGQQK(gl)R_
TMEM109 Ubiquitylation K215 0.498 _ASGAQLEAK(gl)VR_
TOPORS Ubiquitylation K73 -2.412 _ELAASAPARPAPASSEIMASAAK(gl)EFK_
TOPORS Ubiquitylation K76 -2.551 _EFK(gl)MDNFSPK_
TOPORS Ubiquitylation K83 -0.537 -0.928 _MDNFSPK(gl)AGTSK_
TOPORS Phosphorylation S98 -0.529 -0.409 _LQQTVPADAS(ph)PDSK_
TOPORS Ubiquitylation K249 -0.396 0.347 _K(gl)IQEQDIINFRR_
TOPORS Phosphorylation S585 0.204 0.058 _VYS(ph)PYNHR_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_
USP28 Phosphorylation S495 2.593 2.418 _ESTSTESSS(ph)QDVESTFSSPEDSLPK_
USP28 Phosphorylation S1053 -0.658 -0.698 _EPPTIRPNS(ph)PYDLCSR_


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