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Query: CDKN1A

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDKN1A 0 -3.581 1.080 -0.750

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDKN1A Ubiquitylation K188 -2.505 -1.077 _QTSMTDFYHSK(gl)R_

Background Information for CDKN1A:


Pubmed-CDKN1A »
Uniprot-CDKN1A »
Biogrid-CDKN1A »
ProteomicsDB-CDKN1A »

Tumorportal-CDKN1A »
COSMIC-CDKN1A »
GenomeRNAi-CDKN1A »
Genecards-CDKN1A


Protein-protein Interactions for CDKN1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCNA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDKN1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members CDI IPR003175 0.34


Protein complexes (CORUM database) featuring CDKN1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 310 Cell cycle kinase complex CDC2 Database 0.52
Category members Corum 312 Cell cycle kinase complex CDK4 Database 0.06
Category members Corum 311 Cell cycle kinase complex CDK2 Database 0
Category members Corum 313 Cell cycle kinase complex CDK5 Database 0
Category members Corum 314 PCNA-p21 complex Database 0
Category members Corum 5101 CyclinD3-CDK4-CDK6-p21 complex Database 0
Category members Corum 5622 HSP90-CIP1-FKBPL complex Database 0


Categories featuring CDKN1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Database 1.39
Category members GO Category GO:0033158 regulation of protein import into nucleus, translocation Database 1.32
Category members Pathway Pathway_549 REACTOME_GAB1_SIGNALOSOME 0 1.25
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_830 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 0 0.93
Category members GO Category GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Database 0.83
Category members GO Category GO:0009411 response to UV Database 0.79
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members Pathway Pathway_782 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 0 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_708 REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_991 REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0042326 negative regulation of phosphorylation Database 0.5
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members Pathway Pathway_590 REACTOME_PI_3K_CASCADE 0 0.37
Category members Pathway Pathway_607 REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 0 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_744 PID_HDAC_CLASSIII_PATHWAY 0 0.34
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Pathway Pathway_604 REACTOME_PI3K_AKT_ACTIVATION 0 0.32
Category members Pathway Pathway_614 REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 0 0.32
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members Pathway Pathway_1135 PID_PRL_SIGNALING_EVENTS_PATHWAY 0 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members Pathway Pathway_210 PID_CMYB_PATHWAY 0 0.2
Category members Pathway Pathway_1145 BIOCARTA_EPONFKB_PATHWAY 0 0.2
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members Pathway Pathway_698 BIOCARTA_CALCINEURIN_PATHWAY 0 0.11
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members Disease phenotype Multiple_endocrine_neoplasia_type_1 Multiple endocrine neoplasia type 1 Database 0.04
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Pathway Pathway_1164 SA_G1_AND_S_PHASES 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_588 SA_TRKA_RECEPTOR 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members Pathway Pathway_972 SA_G2_AND_M_PHASES 0 0
Category members GO Category GO:0000307 cyclin-dependent protein kinase holoenzyme complex Database 0
Category members GO Category GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0007346 regulation of mitotic cell cycle Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0030890 positive regulation of B cell proliferation Database 0
Category members GO Category GO:0031668 cellular response to extracellular stimulus Database 0
Category members GO Category GO:0043068 positive regulation of programmed cell death Database 0
Category members GO Category GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity Database 0
Category members GO Category GO:0046685 response to arsenic-containing substance Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051412 response to corticosterone Database 0
Category members GO Category GO:0055093 response to hyperoxia Database 0
Category members GO Category GO:0070557 PCNA-p21 complex Database 0


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