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BIOCARTA_G2_PATHWAY
(Pathway_982)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
PRKDC 3 1.430 -1.280 -0.994 -0.672 -0.244 0.307 0.443
BRCA1 2 0.200 -0.140 0.433 0.018 0.146
CHEK1 2 -1.170 1.560
CHEK1 2 -1.170 1.560
PLK1 2 3.098 -0.387 0.212 -1.949 -0.610
CHEK2 2 0.530 0.100
CDC34 1 -0.790 0.600
YWHAQ 1 -0.260 0.670 0.606 0.369 -0.163 0.594 0.478
WEE1 1 -1.790 2.530 0.694
ATR 1 -1.040 0.920 0.671 1.041 0.708
EP300 0 -1.210 1.320 -1.089 -1.694 -0.723
CDC25B 0 -0.180 0.320
GADD45A 0 1.050 -0.170
RPS6KA1 0 -0.160 -0.660
RPS6KA1 0 -0.160 -0.660
CDKN1A 0 1.080 -0.750
YWHAH 0 0.000 0.080 1.206 0.159
YWHAH 0 0.000 0.080 0.546 0.338 0.541
CCNB1 0 -0.410 -0.128 0.212 -0.166 -0.523
MDM2 0 -0.210 0.080
TP53 0 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497
ATM 0 0.398 0.474
CDC25C 0 -0.100 0.100
CDC25A 0 0.260 -0.100
CDK1 0 -0.370 0.080 -0.202 -0.884 -0.107 -0.097 -0.501

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ATM Ubiquitylation K307 -0.196 _GAYESTK(gl)WR_
ATM Ubiquitylation K331 -0.126 _GK(gl)YSSGFR_
ATM Ubiquitylation K385 -0.669 _ESSDYSVPCK(gl)R_
ATM Ubiquitylation K1101 -0.548 _LFQDTK(gl)GDSSR_
ATM Ubiquitylation K1109 -1.666 _LLK(gl)ALPLK_
ATM Ubiquitylation K1698 -1.026 _DASYTK(gl)ALK_
ATM Ubiquitylation K1738 -0.137 _SAAVTCLK(gl)NILATK_
ATM Ubiquitylation K2025 -1.497 _SIGEPDSLYGCGGGK(gl)MLQPITR_
ATR Ubiquitylation K32 -0.929 _ELGSATPEEYNTVVQK(gl)PR_
ATR Phosphorylation S435 0.516 0.284 _RLS(ph)SSLNPSK_
ATR Ubiquitylation K746 -1.823 _NLK(gl)ATSQHECSSSQLK_
ATR Ubiquitylation K1019 1.662 _TLGK(gl)QLNVNRR_
ATR Ubiquitylation K1600 -0.437 _FQALK(gl)AEK_
ATR Ubiquitylation K2106 -0.136 _AYEWEK(gl)AGR_
ATR Ubiquitylation K2604 0.657 1.118 _LQGVIK(gl)TR_
BRCA1 Phosphorylation S123 0.465 0.445 _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_
BRCA1 Phosphorylation S753 2.662 4.077 _VSNNAEDPKDLMLS(ph)GER_
BRCA1 Phosphorylation S1009 0.733 1.028 _KNLLEENFEEHSM(ox)S(ph)PER_
BRCA1 Phosphorylation S1546 1.821 2.105 _NYPS(ph)QEELIK_
BRCA1 Phosphorylation S1564 3.065 _VVDVEEQQLEES(ph)GPHDLTETSYLPR_
BRCA1 Phosphorylation S1664 1.120 _EKPELTAS(ph)TER_
CCNB1 Ubiquitylation K18 -0.455 _AK(gl)INMAGAK_
CCNB1 Ubiquitylation K36 -1.833 -2.301 _VPTAPAATSK(gl)PGLRPR_
CCNB1 Ubiquitylation K59 -0.659 _VSEQLQAK(gl)MPMK_
CCNB1 Ubiquitylation K288 0.578 _QMEMK(gl)ILR_
CDC25A Ubiquitylation K120 1.111 _LLGCSPALK(gl)R_
CDC25B Phosphorylation S117 -0.601 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S118 -0.832 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S241 -2.288 -1.005 _S(ph)VTPPEEQQEAEEPK_
CDC25B Phosphorylation T243 -1.445 _SVT(ph)PPEEQQEAEEPK_
CDC25B Phosphorylation S261 0.275 _S(ph)KSLCHDEIENLLDSDHR_
CDC25B Phosphorylation S263 0.184 _SKS(ph)LCHDEIENLLDSDHR_
CDC25C Phosphorylation S185 -0.645 _YLGS(ph)PITTVPK_
CDC25C Phosphorylation S233 -0.702 -0.657 _SPS(ph)MPENLNRPR_
CDC25C Phosphorylation S280 0.256 0.326 _TVS(ph)LCDITITQMLEEDSNQGHLIGDFSK_
CDC34 Ubiquitylation K157 1.502 _GK(gl)DREYTDIIR_
CDK1 Ubiquitylation K6 0.011 -0.784 _(ac)M(ox)EDYTK(gl)IEK_
CDK1 Ubiquitylation K20 -0.327 -0.270 _IGEGTYGVVYK(gl)GR_
CDK1 Ubiquitylation K33 0.736 0.239 _TTGQVVAMK(gl)K_
CDK1 Ubiquitylation K34 -0.306 _TTGQVVAMKK(gl)_
CDK1 Ubiquitylation K58 0.312 -0.262 _EISLLK(gl)ELR_
CDK1 Ubiquitylation K136 -0.468 _DLK(gl)PQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K145 0.161 -0.954 _DLKPQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K149 -0.038 _GTIK(gl)LADFGLAR_
CDK1 Ubiquitylation K251 -0.047 -1.236 _WK(gl)PGSLASHVK_
CDK1 Ubiquitylation K280 0.179 -1.210 _MLIYDPAK(gl)R_
CDKN1A Ubiquitylation K188 -2.505 -1.077 _QTSMTDFYHSK(gl)R_
CHEK1 Ubiquitylation K53 0.879 _AVDCPENIK(gl)K_
CHEK1 Ubiquitylation K54 0.738 _AVDCPENIKK(gl)_
CHEK1 Phosphorylation S296 -0.098 0.184 _VTS(ph)GGVSESPSGFSK_
CHEK1 Phosphorylation S300 1.091 _VTSGGVS(ph)ESPSGFSK_
CHEK1 Phosphorylation S302 1.750 _VTSGGVSES(ph)PSGFSK_
CHEK1 Phosphorylation S317 1.903 _HIQSNLDFS(ph)PVNSASSEENVK_
CHEK1 Ubiquitylation K399 -0.582 _ETCEK(gl)LGYQWK_
CHEK2 Phosphorylation S260 3.670 3.632 _KFAIGS(ph)AR_
CHEK2 Ubiquitylation K437 -0.826 _TQVSLK(gl)DQITSGK_
EP300 Phosphorylation S1038 -0.672 -0.349 _TEIKEEEDQPSTSATQSS(ph)PAPGQSK_
EP300 Phosphorylation S1726 0.994 0.627 _LGLGLDDESNNQQAAATQS(ph)PGDSRR_
EP300 Phosphorylation S2328 -1.092 0.725 _PQSQPPHSSPS(ph)PR_
GADD45A Ubiquitylation K12 -0.515 0.281 _TLEEFSAGEQK(gl)TER_
GADD45A Ubiquitylation K29 0.092 _VGDALEEVLSK(gl)ALSQR_
MDM2 Phosphorylation S166 0.576 1.068 _AIS(ph)ETEENSDELSGER_
MDM2 Ubiquitylation K334 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K336 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K363 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K364 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K473 0.806 _NK(gl)PCPVCR_
PLK1 Ubiquitylation K358 -2.258 _EK(gl)EEPVVR_
PLK1 Ubiquitylation K574 1.656 _LSLLEEYGCCK(gl)ELASR_
PRKDC Ubiquitylation K108 0.568 -0.049 _IAPYSVEIK(gl)NTCTSVYTK_
PRKDC Ubiquitylation K117 0.540 0.376 _NTCTSVYTK(gl)DR_
PRKDC Ubiquitylation K163 0.679 _FYGELALK(gl)K_
PRKDC Ubiquitylation K164 -0.371 _FYGELALKK(gl)_
PRKDC Ubiquitylation K263 0.272 -0.659 _AIRPQIDLK(gl)R_
PRKDC Ubiquitylation K357 1.479 _NVDSNNK(gl)ELSIAIR_
PRKDC Ubiquitylation K374 -0.342 _GYGLFAGPCK(gl)VINAK_
PRKDC Ubiquitylation K493 -0.582 _ICSK(gl)PVVLPK_
PRKDC Ubiquitylation K689 -0.187 _YFEGVSPK(gl)SLK_
PRKDC Ubiquitylation K810 0.561 0.360 _TSALSDETK(gl)NNWEVSALSR_
PRKDC Ubiquitylation K828 0.723 -0.203 _GFNK(gl)VVLK_
PRKDC Ubiquitylation K832 1.611 -0.278 _VVLK(gl)HLK_
PRKDC Ubiquitylation K838 1.939 1.087 _TK(gl)NLSSNEAISLEEIR_
PRKDC Ubiquitylation K963 -1.201 _ATQMPEGGQGAPPMYQLYK(gl)R_
PRKDC Ubiquitylation K1038 0.646 _EFLK(gl)WSIK_
PRKDC Ubiquitylation K1042 -0.070 -0.432 _WSIK(gl)QITPQQQEK_
PRKDC Ubiquitylation K1051 -1.153 _QITPQQQEK(gl)SPVNTK_
PRKDC Ubiquitylation K1057 -0.693 _SPVNTK(gl)SLFK_
PRKDC Ubiquitylation K1334 0.108 _YNYSK(gl)CTVVVR_
PRKDC Ubiquitylation K1407 -0.971 _ALK(gl)MSPYK_
PRKDC Ubiquitylation K1456 0.657 -0.495 _LAAVVSACK(gl)QLHR_
PRKDC Ubiquitylation K1744 -0.269 _FNNYVDCMK(gl)K_
PRKDC Ubiquitylation K1857 -0.152 _FTK(gl)LNESTFDTQITK_
PRKDC Ubiquitylation K1869 0.803 _LNESTFDTQITK(gl)K_
PRKDC Ubiquitylation K1870 0.843 -0.566 _LNESTFDTQITKK(gl)_
PRKDC Ubiquitylation K1892 -1.132 -1.666 _LPKDDVHAK(gl)ESK_
PRKDC Ubiquitylation K2418 -0.499 _SK(gl)DFVQVMR_
PRKDC Ubiquitylation K2447 -0.500 -1.069 _LK(gl)PVELR_
PRKDC Phosphorylation S2612 -0.226 1.740 _STVLTPMFVETQAS(ph)QGTLQTR_
PRKDC Phosphorylation T2671 -0.097 _SSFDWLTGSSTDPLVDHT(ph)SPSSDSLLFAHK_
PRKDC Phosphorylation S2672 0.083 _SSFDWLTGSSTDPLVDHTS(ph)PSSDSLLFAHK_
PRKDC Phosphorylation S2675 -0.193 _SSFDWLTGSSTDPLVDHTSPSS(ph)DSLLFAHK_
PRKDC Phosphorylation S2677 0.284 -0.009 _SSFDWLTGSSTDPLVDHTSPSSDS(ph)LLFAHK_
PRKDC Ubiquitylation K2694 -1.865 _APLK(gl)SVGPDFGKK_
PRKDC Ubiquitylation K2703 0.600 _SVGPDFGKK(gl)_
PRKDC Ubiquitylation K2715 0.258 -1.356 _LGLPGDEVDNK(gl)VK_
PRKDC Ubiquitylation K2717 -1.795 _LGLPGDEVDNKVK(gl)GAAGR_
PRKDC Ubiquitylation K2738 -0.251 -0.421 _DQEK(gl)LSLMYAR_
PRKDC Ubiquitylation K2758 -0.370 _EKEIK(gl)SELK_
PRKDC Ubiquitylation K2764 0.293 -0.445 _MK(gl)QDAQVVLYR_
PRKDC Ubiquitylation K2829 -1.122 _TLSEK(gl)NNITQK_
PRKDC Ubiquitylation K2908 -0.765 -1.790 _LLPAELPAK(gl)R_
PRKDC Ubiquitylation K2928 0.416 -0.319 _WVELAK(gl)LYR_
PRKDC Ubiquitylation K3158 0.005 -1.352 _QGNLSSQVPLK(gl)R_
PRKDC Ubiquitylation K3192 -0.192 _CFFLSK(gl)IEEK_
PRKDC Phosphorylation S3205 2.096 1.572 _LTPLPEDNS(ph)M(ox)NVDQDGDPSDR_
PRKDC Ubiquitylation K3235 0.810 0.153 _SCK(gl)FSMK_
PRKDC Ubiquitylation K3241 0.107 -0.523 _MK(gl)MIDSAR_
PRKDC Ubiquitylation K3248 0.977 -0.289 _K(gl)QNNFSLAMK_
PRKDC Ubiquitylation K3260 0.018 -1.258 _LLK(gl)ELHK_
PRKDC Ubiquitylation K3455 0.488 -0.615 _ALK(gl)LNSNEAR_
PRKDC Ubiquitylation K3552 1.164 0.277 _NK(gl)EFVAR_
PRKDC Ubiquitylation K3608 1.045 1.399 _NIEK(gl)MYER_
PRKDC Ubiquitylation K3631 -1.002 _K(gl)FIQTFGK_
PRKDC Ubiquitylation K3650 0.475 -0.515 _GGSK(gl)LLR_
PRKDC Ubiquitylation K3710 0.119 -0.965 _GK(gl)PLPEYHVR_
PRKDC Ubiquitylation K3877 0.018 -2.000 _ESK(gl)VPADLLKR_
PRKDC Ubiquitylation K3884 -0.255 -1.203 _VPADLLK(gl)R_
PRKDC Ubiquitylation K4019 -0.937 _NFEQK(gl)MLK_
PRKDC Ubiquitylation K4023 -0.481 _K(gl)GGSWIQEINVAEK_
RPS6KA1 Phosphorylation S227 0.363 0.496 _AYS(ph)FCGTVEYM(ox)APEVVNR_
RPS6KA1 Phosphorylation T231 0.315 _KAYSFCGT(ph)VEYMAPEVVNR_
RPS6KA1 Ubiquitylation K316 -1.156 _LGSGPDGAEEIK(gl)R_
RPS6KA1 Phosphorylation T359 -0.149 -0.339 _T(ph)PKDSPGIPPSAGAHQLFR_
RPS6KA1 Phosphorylation S363 -0.711 -0.697 _TPKDS(ph)PGIPPSAGAHQLFR_
RPS6KA1 Ubiquitylation K566 -0.152 _ICDFGFAK(gl)QLR_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_
WEE1 Phosphorylation S139 -0.678 -0.613 _SPAAPYFLGSSFS(ph)PVR_
YWHAH Ubiquitylation K143 0.540 _YLAEVASGEKK(gl)_
YWHAQ Ubiquitylation K3 0.827 _(ac)MEK(gl)TELIQK_
YWHAQ Ubiquitylation K9 0.588 0.253 _(ac)MEKTELIQK(gl)AK_
YWHAQ Ubiquitylation K11 0.561 0.388 _AK(gl)LAEQAER_
YWHAQ Ubiquitylation K27 -0.849 _YDDMATCMK(gl)AVTEQGAELSNEER_
YWHAQ Ubiquitylation K49 0.260 0.469 _NLLSVAYK(gl)NVVGGR_
YWHAQ Ubiquitylation K68 0.288 _VISSIEQK(gl)TDTSDKK_
YWHAQ Ubiquitylation K74 0.305 _TDTSDK(gl)KLQLIK_
YWHAQ Ubiquitylation K75 0.253 _TDTSDKK(gl)LQLIK_
YWHAQ Ubiquitylation K80 0.655 1.500 _LQLIK(gl)DYR_
YWHAQ Ubiquitylation K85 0.110 _EK(gl)VESELR_
YWHAQ Ubiquitylation K120 0.512 0.946 _VFYLK(gl)MK_
YWHAQ Ubiquitylation K122 0.426 0.859 _MK(gl)GDYFR_
YWHAQ Ubiquitylation K158 -0.439 -0.371 _K(gl)EMQPTHPIR_


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