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Query: BRCA1

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BRCA1 2 7.336 0.200 -0.140 0.433 0.018 0.146

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BRCA1 Phosphorylation S753 2.662 4.077 _VSNNAEDPKDLMLS(ph)GER_
BRCA1 Phosphorylation S1564 3.065 _VVDVEEQQLEES(ph)GPHDLTETSYLPR_
BRCA1 Phosphorylation S1546 1.821 2.105 _NYPS(ph)QEELIK_
BRCA1 Phosphorylation S1664 1.120 _EKPELTAS(ph)TER_
BRCA1 Phosphorylation S1009 0.733 1.028 _KNLLEENFEEHSM(ox)S(ph)PER_
BRCA1 Phosphorylation S123 0.465 0.445 _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_

Background Information for BRCA1:


Pubmed-BRCA1 »
Uniprot-BRCA1 »
Biogrid-BRCA1 »
ProteomicsDB-BRCA1 »

Tumorportal-BRCA1 »
COSMIC-BRCA1 »
GenomeRNAi-BRCA1 »
Genecards-BRCA1


Protein-protein Interactions for BRCA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BRCA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IFI30 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait JUNB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BRCA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BRCT_dom IPR001357 1.59
Category members Znf_RING IPR001841 0
Category members BRCA1 IPR011364 0
Category members Znf_C3HC4_RING-type IPR018957 0


Protein complexes (CORUM database) featuring BRCA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 2815 BRCA1-BARD1-BACH1-DNA damage complex II Database 1.57
Category members Corum 238 SWI-SNF chromatin remodeling-related-BRCA1 complex Database 1.57
Category members Corum 2825 BRCA1-RNA polymerase II complex Database 1.38
Category members Corum 202 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 964 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 436 BASC (Ab C-20) complex (BRCA1-associated genome surveillance complex) Database 0.88
Category members Corum 2814 BRCA1-HDAC1-HDAC2 complex Database 0.85
Category members Corum 434 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) Database 0.83
Category members Corum 2817 BRCA1-BARD1-BACH1-DNA damage complex I Database 0.79
Category members Corum 2786 BRCA1 A complex Database 0.68
Category members Corum 2213 BRCA1-BARD1-POLR2A complex Database 0.66
Category members Corum 2787 BRCA1 C complex Database 0.66
Category members Corum 2823 BRCA1-BARD1-UbcH7c complex Database 0.57
Category members Corum 2686 BRCA1-core RNA polymerase II complex Database 0.51
Category members Corum 2776 RAD50-BRCA1 complex Database 0.37
Category members Corum 2820 BRCA1-VCP complex Database 0.36
Category members Corum 242 BRCA1-BACH1 complex Database 0.28
Category members Corum 201 HUIC complex Database 0.28
Category members Corum 435 BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) Database 0.23
Category members Corum 2811 BRCA1-cABL complex Database 0.18
Category members Corum 2813 BRCA1-SMAD3 complex Database 0.11
Category members Corum 2783 BARD1-BRCA1-CSTF64 complex Database 0.06
Category members Corum 2788 BRCA1 B complex Database 0.06
Category members Corum 2818 BRCA1-BARD1-BRCA2-DNA damage complex III Database 0.06
Category members Corum 2822 BRCA1-BARD1-UbcH5c complex Database 0.06
Category members Corum 438 GCN5-TRRAP histone acetyltransferase complex Database 0.05
Category members Corum 2211 BARD1-BRCA1-CSTF complex Database 0
Category members Corum 2214 LMO4-BRCA1-CTIP-LDB1 complex Database 0
Category members Corum 2215 BRCA1-LMO4-CTIP complex Database 0
Category members Corum 240 BRCA1-CTIP-ZBRK1 repressor complex Database 0
Category members Corum 2819 BRCA1-CtIP-CtBP complex Database 0
Category members Corum 2824 BRCA1-RAD51 complex Database 0
Category members Corum 5400 BRCC complex Database 0


Categories featuring BRCA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members GO Category GO:0005694 chromosome Database 3.87
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0006349 regulation of gene expression by genetic imprinting Database 1.64
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage Database 1.14
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_185 PID_ERA_GENOMIC_PATHWAY 0 1.05
Category members GO Category GO:0051571 positive regulation of histone H3-K4 methylation Database 0.99
Category members GO Category GO:0051573 negative regulation of histone H3-K9 methylation Database 0.84
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members Disease phenotype BREAST_CANCER BREAST CANCER Database 0.62
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0043627 response to estrogen Database 0.4
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0031436 BRCA1-BARD1 complex Database 0.28
Category members GO Category GO:0034446 substrate adhesion-dependent cell spreading Database 0.26
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0051865 protein autoubiquitination Database 0.18
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members GO Category GO:0071158 positive regulation of cell cycle arrest Database 0.11
Category members GO Category GO:0051572 negative regulation of histone H3-K4 methylation Database 0.08
Category members GO Category GO:0035067 negative regulation of histone acetylation Database 0.08
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members Disease phenotype Familial_prostate_cancer Familial prostate cancer Database 0.07
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members Disease phenotype Familial_pancreatic_carcinoma Familial pancreatic carcinoma Database 0.06
Category members GO Category GO:0046600 negative regulation of centriole replication Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0044030 regulation of DNA methylation Database 0.05
Category members GO Category GO:0070531 BRCA1-A complex Database 0.04
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members Disease phenotype Intellectual_disability Intellectual disability Database 0.04
Category members GO Category GO:0045717 negative regulation of fatty acid biosynthetic process Database 0.02
Category members Disease phenotype OVARIAN_CANCER OVARIAN CANCER Database 0.01
Category members GO Category GO:0031941 filamentous actin Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_186 PID_HNF3A_PATHWAY 0 0
Category members Pathway Pathway_365 BIOCARTA_CARM_ER_PATHWAY 0 0
Category members Disease phenotype Hereditary_breast_cancer Hereditary breast cancer Database 0
Category members Disease phenotype Hereditary_site-specific_ovarian_cancer_syndrome Hereditary site-specific ovarian cancer syndrome Database 0
Category members GO Category GO:0006301 postreplication repair Database 0
Category members GO Category GO:0006359 regulation of transcription from RNA polymerase III promoter Database 0
Category members GO Category GO:0006633 fatty acid biosynthetic process Database 0
Category members GO Category GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Database 0
Category members GO Category GO:0007098 centrosome cycle Database 0
Category members GO Category GO:0008274 gamma-tubulin ring complex Database 0
Category members GO Category GO:0009048 dosage compensation by inactivation of X chromosome Database 0
Category members GO Category GO:0031398 positive regulation of protein ubiquitination Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0
Category members GO Category GO:0035066 positive regulation of histone acetylation Database 0
Category members GO Category GO:0043009 chordate embryonic development Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051574 positive regulation of histone H3-K9 methylation Database 0


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