Results for the Category
Hereditary breast and ovarian cancer syndrome
(Hereditary_breast_and_ovarian_cancer_syndrome)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| RAD50 | 3 | 0.350 | -0.420 | 0.165 | 0.571 | 0.509 | 0.691 | 0.587 |
| BRCA1 | 2 | 0.200 | -0.140 | 0.433 | 0.018 | 0.146 | ||
| NBN | 2 | -0.220 | -0.170 | 0.708 | 0.569 | -0.563 | 0.354 | |
| CHEK2 | 2 | 0.530 | 0.100 | |||||
| PALB2 | 1 | -1.420 | 3.110 | |||||
| BRIP1 | 1 | 0.650 | -0.340 | |||||
| MRE11A | 0 | 1.600 | -0.730 | 0.145 | 0.420 | |||
| MRE11A | 0 | 1.600 | -0.730 | 0.023 | 0.453 | 0.150 | ||
| RAD51 | 0 | -1.260 | 1.920 | |||||
| RAD51C | 0 | 0.400 | 0.260 | |||||
| BARD1 | 0 | 0.470 | 0.260 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| BARD1 | Phosphorylation | S186 | 0.193 | 0.942 | _DASAQQDSYEFVSPS(ph)PPADVSER_ |
| BRCA1 | Phosphorylation | S123 | 0.465 | 0.445 | _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_ |
| BRCA1 | Phosphorylation | S753 | 2.662 | 4.077 | _VSNNAEDPKDLMLS(ph)GER_ |
| BRCA1 | Phosphorylation | S1009 | 0.733 | 1.028 | _KNLLEENFEEHSM(ox)S(ph)PER_ |
| BRCA1 | Phosphorylation | S1546 | 1.821 | 2.105 | _NYPS(ph)QEELIK_ |
| BRCA1 | Phosphorylation | S1564 | 3.065 | _VVDVEEQQLEES(ph)GPHDLTETSYLPR_ | |
| BRCA1 | Phosphorylation | S1664 | 1.120 | _EKPELTAS(ph)TER_ | |
| BRIP1 | Phosphorylation | S112 | 0.807 | 1.459 | _HFNYPS(ph)TPPSER_ |
| BRIP1 | Phosphorylation | T113 | 1.675 | _HFNYPST(ph)PPSER_ | |
| BRIP1 | Phosphorylation | S206 | -0.381 | _INSFS(ph)PQKPPGHCSR_ | |
| BRIP1 | Ubiquitylation | K764 | -0.462 | _GK(gl)VSEGLDFSDDNAR_ | |
| BRIP1 | Ubiquitylation | K797 | -0.723 | 0.188 | _DLQVELK(gl)R_ |
| BRIP1 | Phosphorylation | S1032 | -0.789 | -0.532 | _ATPELGSSENSASS(ph)PPR_ |
| BRIP1 | Phosphorylation | S1237 | 0.424 | 0.355 | _NFKPS(ph)PSK_ |
| CHEK2 | Phosphorylation | S260 | 3.670 | 3.632 | _KFAIGS(ph)AR_ |
| CHEK2 | Ubiquitylation | K437 | -0.826 | _TQVSLK(gl)DQITSGK_ | |
| MRE11A | Ubiquitylation | K387 | 0.442 | _FSQK(gl)FVDR_ | |
| NBN | Phosphorylation | T335 | -1.121 | _T(ph)TTPGPSLSQGVSVDEK_ | |
| NBN | Phosphorylation | S341 | 3.085 | _TTTPGPS(ph)LSQGVSVDEK_ | |
| NBN | Phosphorylation | S343 | 3.710 | 3.629 | _TTTPGPSLS(ph)QGVSVDEK_ |
| NBN | Phosphorylation | S397 | 2.719 | 1.458 | _MLS(ph)QDAPTVK_ |
| NBN | Phosphorylation | S432 | -0.192 | -0.395 | _IPNYQLS(ph)PTK_ |
| NBN | Phosphorylation | T434 | -0.188 | -0.683 | _IPNYQLSPT(ph)KLPSINK_ |
| NBN | Phosphorylation | S615 | 1.985 | 4.691 | _IS(ph)QENEIGKK_ |
| PALB2 | Phosphorylation | S190 | 1.462 | 1.104 | _NPARS(ph)PVTEIR_ |
| PALB2 | Phosphorylation | S387 | -1.951 | _SLS(ph)LEATS(ph)PLSAEK_ | |
| PALB2 | Phosphorylation | S660 | 0.033 | -0.373 | _EGSCIFPEELS(ph)PK_ |
| RAD50 | Ubiquitylation | K62 | -1.069 | _YICTGDFPPGTK(gl)GNTFVHDPK_ | |
| RAD50 | Phosphorylation | S635 | 2.474 | 3.050 | _LFDVCGS(ph)QDFESDLDR_ |
| RAD50 | Ubiquitylation | K753 | 0.394 | 0.397 | _NK(gl)LQNVNR_ |
| RAD50 | Ubiquitylation | K933 | 0.397 | _FQQEKEELINKK(gl)_ | |
| RAD50 | Ubiquitylation | K1068 | 0.098 | _LEENIDNIK(gl)R_ | |
| RAD50 | Ubiquitylation | K1178 | -0.548 | _SDADENVSASDK(gl)RR_ | |
| RAD50 | Ubiquitylation | K1285 | 2.195 | _SEYVEK(gl)FYR_ | |
| RAD51 | Ubiquitylation | K64 | -1.228 | _KELINIK(gl)GISEAK_ | |
| RAD51C | Phosphorylation | S20 | -0.880 | -0.922 | _DLVSFPLS(ph)PAVR_ |
| RAD51C | Ubiquitylation | K72 | -1.746 | -0.333 | _ECLTNK(gl)PR_ |
| RAD51C | Ubiquitylation | K328 | -0.364 | _LATLYK(gl)SPSQK_ |
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