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Query: RAD51C

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAD51C 0 -3.881 0.400 0.260

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAD51C Ubiquitylation K72 -1.746 -0.333 _ECLTNK(gl)PR_
RAD51C Ubiquitylation K328 -0.364 _LATLYK(gl)SPSQK_
RAD51C Phosphorylation S20 -0.880 -0.922 _DLVSFPLS(ph)PAVR_

Background Information for RAD51C:


Pubmed-RAD51C »
Uniprot-RAD51C »
Biogrid-RAD51C »
ProteomicsDB-RAD51C »

Tumorportal-RAD51C »
COSMIC-RAD51C »
GenomeRNAi-RAD51C »
Genecards-RAD51C


Protein-protein Interactions for RAD51C
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAMTS4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EFNB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM174A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HENMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD51C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPACA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAD51C
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members DNA_repair_Rad51/TF_NusA_a-hlx IPR010995 0.23
Category members DNA_recomb/repair_RecA-like IPR016467 0.04
Category members DNA_recomb/repair_Rad51_C IPR013632 0
Category members Circ_KaiC/RadA IPR014774 0
Category members RecA_ATP-bd IPR020588 0


Protein complexes (CORUM database) featuring RAD51C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1196 RAD51C-XRCC3 complex Database 0.28
Category members Corum 252 RAD51C-XRCC3 complex Database 0.28
Category members Corum 253 RAD51C-XRCC3 complex Database 0.28
Category members Corum 259 RAD51C-XRCC3 complex Database 0.28
Category members Corum 251 BCDX2 complex Database 0
Category members Corum 256 RAD51B-RAD51C complex Database 0
Category members Corum 258 BCDX2 complex Database 0
Category members Corum 260 RAD51B-RAD51C complex Database 0
Category members Corum 261 RAD51B-RAD51C-RAD51D-XRCC2-XRCC3 complex Database 0
Category members Corum 68 BCDX2 complex Database 0
Category members Corum 773 Y14-Magoh complex Database 0


Categories featuring RAD51C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members GO Category GO:0007062 sister chromatid cohesion Database 0.69
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0008821 crossover junction endodeoxyribonuclease activity Database 0.04
Category members GO Category GO:0006259 DNA metabolic process Database 0
Category members GO Category GO:0007066 female meiosis sister chromatid cohesion Database 0
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0007141 male meiosis I Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0


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