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Query: NBN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NBN 2 9.299 -0.220 -0.170 0.708 0.569 -0.563 0.354

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NBN Phosphorylation S615 1.985 4.691 _IS(ph)QENEIGKK_
NBN Phosphorylation S343 3.710 3.629 _TTTPGPSLS(ph)QGVSVDEK_
NBN Phosphorylation S397 2.719 1.458 _MLS(ph)QDAPTVK_
NBN Phosphorylation S432 -0.192 -0.395 _IPNYQLS(ph)PTK_
NBN Phosphorylation T434 -0.188 -0.683 _IPNYQLSPT(ph)KLPSINK_
NBN Phosphorylation T335 -1.121 _T(ph)TTPGPSLSQGVSVDEK_
NBN Phosphorylation S341 3.085 _TTTPGPS(ph)LSQGVSVDEK_

Background Information for NBN:


Pubmed-NBN »
Uniprot-NBN »
Biogrid-NBN »
ProteomicsDB-NBN »

Tumorportal-NBN »
COSMIC-NBN »
GenomeRNAi-NBN »
Genecards-NBN


Protein-protein Interactions for NBN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZTS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RGS20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NBN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FHA_dom IPR000253 2.3
Category members BRCT_dom IPR001357 1.59
Category members SMAD_FHA_domain IPR008984 0.86


Protein complexes (CORUM database) featuring NBN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1189 DNA double-strand break end-joining complex Database 2.16
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 2815 BRCA1-BARD1-BACH1-DNA damage complex II Database 1.57
Category members Corum 202 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 2218 MDC1-MRE11-RAD50-NBS1 complex Database 1.09
Category members Corum 619 MRE11A-RAD50-NBN-TRF2 complex Database 1.09
Category members Corum 627 MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) Database 1.09
Category members Corum 964 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 2217 MDC1-MRN-ATM-FANCD2 complex Database 1.08
Category members Corum 5197 PTIP-DNA damage response complex Database 0.94
Category members Corum 1081 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 173 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 2767 RAD50-MRE11-NBN-p200-p350 complex Database 0.62
Category members Corum 331 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 618 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 71 MRN complex (MRE11-RAD50-NBS1 complex) Database 0.62
Category members Corum 73 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 972 MRN complex (MRE11-RAD50-NBS1 complex) Database 0.62
Category members Corum 2723 ATM-NBS1 complex Database 0


Categories featuring NBN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0030870 Mre11 complex Database 1.75
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members GO Category GO:0005657 replication fork Database 0.95
Category members GO Category GO:0001832 blastocyst growth Database 0.83
Category members GO Category GO:0042405 nuclear inclusion body Database 0.82
Category members GO Category GO:0035861 site of double-strand break Database 0.65
Category members Disease phenotype BREAST_CANCER BREAST CANCER Database 0.62
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0033674 positive regulation of kinase activity Database 0.3
Category members GO Category GO:0007093 mitotic cell cycle checkpoint Database 0.27
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members GO Category GO:0045190 isotype switching Database 0.11
Category members Disease phenotype Familial_prostate_cancer Familial prostate cancer Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0030330 DNA damage response, signal transduction by p53 class mediator Database 0.04
Category members GO Category GO:0030174 regulation of DNA-dependent DNA replication initiation Database 0.04
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members GO Category GO:0007126 meiosis Database 0.01
Category members Disease phenotype APLASTIC_ANEMIA APLASTIC ANEMIA Database 0
Category members GO Category GO:0000075 cell cycle checkpoint Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0007095 mitotic G2 DNA damage checkpoint Database 0
Category members GO Category GO:0031954 positive regulation of protein autophosphorylation Database 0


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