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PID_FANCONI_PATHWAY
(Pathway_873)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPA1 6 0.500 0.350 3.133 3.046 0.303 1.770 2.112
FANCD2 5 -0.650 0.520 1.226 0.362 -0.007 1.535 0.808
RAD50 3 0.350 -0.420 0.165 0.571 0.509 0.691 0.587
RPA2 3 -1.830 3.700 1.524
RPA2 3 -1.830 3.700 2.592
FANCI 3 -0.230 -0.130 -0.878 0.258 0.641 1.631 0.954
TOPBP1 3 -2.480 4.260 -0.269 0.277
BRCA1 2 0.200 -0.140 0.433 0.018 0.146
NBN 2 -0.220 -0.170 0.708 0.569 -0.563 0.354
CHEK1 2 -1.170 1.560
CHEK1 2 -1.170 1.560
ATRIP 2 -1.370 1.920 -0.656 0.735 0.448
H2AFX 2 -0.474 -0.395 0.182 0.824 0.499
H2AFX 2
PALB2 1 -1.420 3.110
FANCL 1 -0.070 -0.020
BRIP1 1 0.650 -0.340
USP1 1 2.430 -1.190
RAD9A 1 -2.070 3.350
ATR 1 -1.040 0.920 0.671 1.041 0.708
TOP3A 1 2.070 -0.580 -0.370 0.720
TOP3A 1 2.070 -0.580 0.498 0.705
FANCA 1 -1.940 3.290
FANCA 1 -1.940 3.290 0.441
MRE11A 0 1.600 -0.730 0.145 0.420
MRE11A 0 1.600 -0.730 0.023 0.453 0.150
FBXW11 0 -0.780 0.530 0.532 -1.791 0.313
UBE2T 0 0.090 0.230
RFC5 0 0.500 -0.920
RFC5 0 0.500 -0.920 -1.112 -0.547 0.316 -0.391 0.586
FANCE 0 -0.390 0.490
RAD1 0 0.550 0.120
HES1 0 -0.940 0.860
WDR48 0 0.940 -0.610 0.277 -0.306 -0.478
XRCC3 0 0.420 -0.620
RFC3 0 0.010 -0.490 0.265 -0.461 0.387 0.658 0.371
ATM 0 0.398 0.474
FANCC 0 1.030 -0.520
RFC4 0 1.100 -0.890 -0.721 -0.389 0.425 -0.194 0.037
FANCF 0 1.290 -1.060
FAAP100 0 -0.470 0.820 0.589 0.736
BLM 0 1.270 -0.830 -0.850 -0.141 0.144 0.151 0.149
BLM 0 1.270 -0.830
FANCG 0 0.390 -0.740 0.107 0.986

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ATM Ubiquitylation K307 -0.196 _GAYESTK(gl)WR_
ATM Ubiquitylation K331 -0.126 _GK(gl)YSSGFR_
ATM Ubiquitylation K385 -0.669 _ESSDYSVPCK(gl)R_
ATM Ubiquitylation K1101 -0.548 _LFQDTK(gl)GDSSR_
ATM Ubiquitylation K1109 -1.666 _LLK(gl)ALPLK_
ATM Ubiquitylation K1698 -1.026 _DASYTK(gl)ALK_
ATM Ubiquitylation K1738 -0.137 _SAAVTCLK(gl)NILATK_
ATM Ubiquitylation K2025 -1.497 _SIGEPDSLYGCGGGK(gl)MLQPITR_
ATR Ubiquitylation K32 -0.929 _ELGSATPEEYNTVVQK(gl)PR_
ATR Phosphorylation S435 0.516 0.284 _RLS(ph)SSLNPSK_
ATR Ubiquitylation K746 -1.823 _NLK(gl)ATSQHECSSSQLK_
ATR Ubiquitylation K1019 1.662 _TLGK(gl)QLNVNRR_
ATR Ubiquitylation K1600 -0.437 _FQALK(gl)AEK_
ATR Ubiquitylation K2106 -0.136 _AYEWEK(gl)AGR_
ATR Ubiquitylation K2604 0.657 1.118 _LQGVIK(gl)TR_
ATRIP Phosphorylation S224 -0.208 -0.178 _LAAPSVSHVS(ph)PR_
ATRIP Phosphorylation S239 0.401 _KNPSVVIKPEACS(ph)PQFGK_
ATRIP Phosphorylation S518 1.549 1.561 _SLVHRLS(ph)DGDM(ox)TSALR_
BLM Phosphorylation S144 1.234 _KLEFSSS(ph)PDSLSTINDWDDMDDFDTSETSK_
BRCA1 Phosphorylation S123 0.465 0.445 _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_
BRCA1 Phosphorylation S753 2.662 4.077 _VSNNAEDPKDLMLS(ph)GER_
BRCA1 Phosphorylation S1009 0.733 1.028 _KNLLEENFEEHSM(ox)S(ph)PER_
BRCA1 Phosphorylation S1546 1.821 2.105 _NYPS(ph)QEELIK_
BRCA1 Phosphorylation S1564 3.065 _VVDVEEQQLEES(ph)GPHDLTETSYLPR_
BRCA1 Phosphorylation S1664 1.120 _EKPELTAS(ph)TER_
BRIP1 Phosphorylation S112 0.807 1.459 _HFNYPS(ph)TPPSER_
BRIP1 Phosphorylation T113 1.675 _HFNYPST(ph)PPSER_
BRIP1 Phosphorylation S206 -0.381 _INSFS(ph)PQKPPGHCSR_
BRIP1 Ubiquitylation K764 -0.462 _GK(gl)VSEGLDFSDDNAR_
BRIP1 Ubiquitylation K797 -0.723 0.188 _DLQVELK(gl)R_
BRIP1 Phosphorylation S1032 -0.789 -0.532 _ATPELGSSENSASS(ph)PPR_
BRIP1 Phosphorylation S1237 0.424 0.355 _NFKPS(ph)PSK_
CHEK1 Ubiquitylation K53 0.879 _AVDCPENIK(gl)K_
CHEK1 Ubiquitylation K54 0.738 _AVDCPENIKK(gl)_
CHEK1 Phosphorylation S296 -0.098 0.184 _VTS(ph)GGVSESPSGFSK_
CHEK1 Phosphorylation S300 1.091 _VTSGGVS(ph)ESPSGFSK_
CHEK1 Phosphorylation S302 1.750 _VTSGGVSES(ph)PSGFSK_
CHEK1 Phosphorylation S317 1.903 _HIQSNLDFS(ph)PVNSASSEENVK_
CHEK1 Ubiquitylation K399 -0.582 _ETCEK(gl)LGYQWK_
FAAP100 Phosphorylation S667 -0.762 _APS(ph)PLGPTRDPVATFLETCR_
FANCA Ubiquitylation K44 -0.981 _LK(gl)ESAVR_
FANCA Ubiquitylation K249 -0.498 -0.588 _GFQK(gl)NSDLRR_
FANCA Ubiquitylation K261 0.217 _TVEPEK(gl)MPQVTVDVLQR_
FANCA Ubiquitylation K608 -0.873 _VAFIESLK(gl)R_
FANCA Ubiquitylation K1079 -0.322 _ELLMYK(gl)R_
FANCA Ubiquitylation K1199 -0.882 _ELQK(gl)LQEGR_
FANCA Ubiquitylation K1387 -0.462 _SLELK(gl)GQAGQPR_
FANCC Ubiquitylation K552 -0.114 _ELLK(gl)ELR_
FANCD2 Ubiquitylation K77 -0.288 _TGESQNQLAVDQIAFQK(gl)K_
FANCD2 Ubiquitylation K137 0.364 _LQDEEASMGASYSKSLIK(gl)_
FANCD2 Ubiquitylation K322 -0.535 _LQASQVK(gl)LK_
FANCD2 Ubiquitylation K324 -0.384 _LQASQVKLK(gl)_
FANCD2 Ubiquitylation K561 2.102 3.950 _K(gl)QLSSTVFKYK_
FANCD2 Phosphorylation S592 1.311 1.350 _SES(ph)PSLTQER_
FANCD2 Phosphorylation S717 2.435 3.130 _DGGPVTS(ph)QESGQK_
FANCD2 Phosphorylation S1401 -0.015 _S(ph)QNSQESTADESEDDMSSQASK_
FANCD2 Phosphorylation S1404 -0.348 _S(ph)QNSQESTADESEDDMSSQASK_
FANCD2 Phosphorylation S1412 -1.471 _SQNSQESTADES(ph)EDDM(ox)SSQASK_
FANCE Phosphorylation S249 -0.010 -0.066 _SLESLADGGSAS(ph)PIKDQPVMAVK_
FANCF Ubiquitylation K186 -1.299 _LQEVGK(gl)AEAERPAR_
FANCF Ubiquitylation K331 -2.113 _FQSLCQAPPPLKDK(gl)_
FANCG Ubiquitylation K28 -0.599 _QAK(gl)VAQNSGLTLR_
FANCG Ubiquitylation K504 -1.806 _ATPEEKEQGAAFNCEQGCK(gl)SDAALQQLR_
FANCI Ubiquitylation K39 -0.484 _EGDLTNLLQNQAVK(gl)GK_
FANCI Ubiquitylation K41 -0.316 _GK(gl)VAGALLR_
FANCI Ubiquitylation K52 -0.505 _AIFK(gl)GSPCSEEAGTLR_
FANCI Ubiquitylation K148 0.699 -0.432 _ENLAYGK(gl)GVLSGEECKK_
FANCI Ubiquitylation K158 -0.795 _GVLSGEECKK(gl)_
FANCI Ubiquitylation K339 -1.516 _SFK(gl)DLQLLQGSK_
FANCI Ubiquitylation K397 -1.601 -1.698 _K(gl)VLDGKTIETSPSLSR_
FANCI Ubiquitylation K402 -0.883 -0.723 _VLDGK(gl)TIETSPSLSR_
FANCI Phosphorylation S407 -0.015 -0.064 _TIETS(ph)PSLSR_
FANCI Phosphorylation S409 -0.415 -0.284 _TIETSPS(ph)LSR_
FANCI Ubiquitylation K523 1.893 3.473 _K(gl)AMFANQLDARK_
FANCI Ubiquitylation K715 -0.085 _MIK(gl)SELEDFELDK_
FANCI Ubiquitylation K788 -0.698 _KLSDILNEK(gl)AGK_
FANCI Ubiquitylation K849 -0.807 _YAVNVALQK(gl)VQQLK_
FANCI Ubiquitylation K854 -1.893 _VQQLK(gl)ETGHVSGPDGQNPEK_
FANCI Ubiquitylation K898 2.629 -0.994 _YTSIPTSVEESGKK(gl)_
FANCI Ubiquitylation K902 -0.694 _GK(gl)SISLLCLEGLQK_
FANCI Ubiquitylation K1221 0.305 _SK(gl)SLNYTGEK_
FANCI Ubiquitylation K1230 -0.133 -1.162 _SLNYTGEKK(gl)_
FANCI Ubiquitylation K1269 0.901 _FLIHLSK(gl)K_
FANCL Ubiquitylation K22 -0.421 _SK(gl)TVYEGFISAQGR_
FANCL Ubiquitylation K49 2.798 _IVLPEDLQLK(gl)NAR_
FBXW11 Ubiquitylation K466 0.325 _IVSGAYDGKIK(gl)_
H2AFX Ubiquitylation K116 -0.071 _ATIAGGGVIPHIHK(gl)SLIGK_
H2AFX Ubiquitylation K120 0.702 0.181 _K(gl)TSATVGPK_
H2AFX Ubiquitylation K121 1.548 0.818 _SLIGK(gl)K(gl)GQQK_
H2AFX Ubiquitylation K122 1.238 -0.400 _SLIGK(gl)K(gl)GQQK_
H2AFX Ubiquitylation K126 1.132 _KGQQK(gl)TV_
H2AFX Ubiquitylation K128 -0.411 0.117 _KTSATVGPK(gl)APSGGKK_
H2AFX Phosphorylation S140 1.817 1.205 _KATQAS(ph)QEY_
HES1 Ubiquitylation K66 0.212 _TLILDALK(gl)K_
HES1 Ubiquitylation K67 0.212 _TLILDALK(gl)K_
HES1 Ubiquitylation K109 -0.891 _AQMTAALSTDPSVLGK(gl)YR_
MRE11A Ubiquitylation K387 0.442 _FSQK(gl)FVDR_
NBN Phosphorylation T335 -1.121 _T(ph)TTPGPSLSQGVSVDEK_
NBN Phosphorylation S341 3.085 _TTTPGPS(ph)LSQGVSVDEK_
NBN Phosphorylation S343 3.710 3.629 _TTTPGPSLS(ph)QGVSVDEK_
NBN Phosphorylation S397 2.719 1.458 _MLS(ph)QDAPTVK_
NBN Phosphorylation S432 -0.192 -0.395 _IPNYQLS(ph)PTK_
NBN Phosphorylation T434 -0.188 -0.683 _IPNYQLSPT(ph)KLPSINK_
NBN Phosphorylation S615 1.985 4.691 _IS(ph)QENEIGKK_
PALB2 Phosphorylation S190 1.462 1.104 _NPARS(ph)PVTEIR_
PALB2 Phosphorylation S387 -1.951 _SLS(ph)LEATS(ph)PLSAEK_
PALB2 Phosphorylation S660 0.033 -0.373 _EGSCIFPEELS(ph)PK_
RAD1 Ubiquitylation K46 0.748 _EHATCFATK(gl)NGIK_
RAD50 Ubiquitylation K62 -1.069 _YICTGDFPPGTK(gl)GNTFVHDPK_
RAD50 Phosphorylation S635 2.474 3.050 _LFDVCGS(ph)QDFESDLDR_
RAD50 Ubiquitylation K753 0.394 0.397 _NK(gl)LQNVNR_
RAD50 Ubiquitylation K933 0.397 _FQQEKEELINKK(gl)_
RAD50 Ubiquitylation K1068 0.098 _LEENIDNIK(gl)R_
RAD50 Ubiquitylation K1178 -0.548 _SDADENVSASDK(gl)RR_
RAD50 Ubiquitylation K1285 2.195 _SEYVEK(gl)FYR_
RAD9A Phosphorylation S277 -0.249 -0.052 _DSLLDGHFVLATLSDTDSHSQDLGS(ph)PER_
RFC3 Ubiquitylation K66 -1.522 _ELYGVGVEK(gl)LR_
RFC3 Ubiquitylation K80 -1.498 -2.261 _IEHQTITTPSKK(gl)_
RFC3 Ubiquitylation K154 -1.667 -0.110 _TMEK(gl)YMSTCR_
RFC3 Ubiquitylation K170 -1.470 -0.431 _LILCCNSTSK(gl)VIPPIR_
RFC3 Ubiquitylation K202 -0.332 -0.849 _K(gl)EGLNLPSQLAHR_
RFC3 Ubiquitylation K225 -0.218 _K(gl)ALLMCEACR_
RFC4 Ubiquitylation K205 0.306 _FKPLSDK(gl)IQQQR_
RFC4 Ubiquitylation K217 -0.818 _LLDIAKK(gl)_
RFC4 Ubiquitylation K240 0.204 _K(gl)AITFLQSATR_
RFC5 Ubiquitylation K16 0.039 -0.820 _QQEQPAATK(gl)IR_
RFC5 Ubiquitylation K270 0.495 _NITELK(gl)TLK_
RPA1 Ubiquitylation K163 2.827 4.085 _AYGASK(gl)TFGK_
RPA1 Ubiquitylation K167 3.009 3.243 _TFGK(gl)AAGPSLSHTSGGTQSK_
RPA1 Ubiquitylation K183 0.925 _AAGPSLSHTSGGTQSK(gl)VVPIASLTPYQSK_
RPA1 Ubiquitylation K263 -1.803 _GTLK(gl)IANK_
RPA1 Ubiquitylation K267 2.751 _IANK(gl)QFTAVK_
RPA1 Ubiquitylation K331 3.112 4.066 _SYEDATK(gl)ITVR_
RPA1 Ubiquitylation K410 2.458 _SLSVLSSSTIIANPDIPEAYK(gl)LR_
RPA1 Ubiquitylation K489 0.465 2.335 _K(gl)VIDQQNGLYR_
RPA1 Ubiquitylation K588 -0.055 _IK(gl)ATVMDVKPVDYR_
RPA1 Ubiquitylation K595 1.201 _ATVMDVK(gl)PVDYR_
RPA2 Ubiquitylation K85 0.693 _HAEK(gl)APTNIVYK_
RPA2 Ubiquitylation K235 1.339 _NQLK(gl)HMSVSSIK_
TOPBP1 Ubiquitylation K789 -0.950 _FQSK(gl)AFR_
TOPBP1 Phosphorylation S888 2.918 1.917 _NAVALSAS(ph)PQLK_
UBE2T Ubiquitylation K91 -0.306 0.175 _ICLDVLK(gl)LPPK_
UBE2T Ubiquitylation K141 -0.260 _YNKPAFLK(gl)NAR_
UBE2T Ubiquitylation K192 -0.193 _ASQLVGIEKK(gl)_
USP1 Phosphorylation S42 1.055 _ALDFTDS(ph)QENEEK_
USP1 Phosphorylation S66 0.045 _ASEIDQVVPAAQS(ph)SPINCEK_
USP1 Phosphorylation S67 -0.170 0.304 _ASEIDQVVPAAQSS(ph)PINCEK_
USP1 Phosphorylation S475 -1.080 -0.086 _REDFQDISVPVQEDELSKVEESSEIS(ph)PEPK_
USP1 Ubiquitylation K689 0.173 -1.509 _ASNPDK(gl)VASTAFAENR_
WDR48 Ubiquitylation K294 0.228 _VLICEEK(gl)APVLK_
XRCC3 Ubiquitylation K17 -1.225 _IIAAIK(gl)K_
XRCC3 Ubiquitylation K36 -0.644 _EVLHFSGPDLK(gl)R_
XRCC3 Ubiquitylation K72 -0.839 _GSSILTALQLHQQK(gl)ER_


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