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Query: H2AFX

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
H2AFX 2 6.024
H2AFX 2 6.024 -0.474 -0.395 0.182 0.824 0.499

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
H2AFX Phosphorylation S140 1.817 1.205 _KATQAS(ph)QEY_
H2AFX Ubiquitylation K121 1.548 0.818 _SLIGK(gl)K(gl)GQQK_
H2AFX Ubiquitylation K120 0.702 0.181 _K(gl)TSATVGPK_
H2AFX Ubiquitylation K128 -0.411 0.117 _KTSATVGPK(gl)APSGGKK_
H2AFX Ubiquitylation K122 1.238 -0.400 _SLIGK(gl)K(gl)GQQK_
H2AFX Ubiquitylation K116 -0.071 _ATIAGGGVIPHIHK(gl)SLIGK_
H2AFX Ubiquitylation K126 1.132 _KGQQK(gl)TV_
H2AFX Ubiquitylation K119 -0.262 _LLGGVTIAQGGVLPNIQAVLLPK(gl)K_

Background Information for H2AFX:


Pubmed-H2AFX »
Uniprot-H2AFX »
Biogrid-H2AFX »
ProteomicsDB-H2AFX »

Tumorportal-H2AFX »
COSMIC-H2AFX »
GenomeRNAi-H2AFX »
Genecards-H2AFX


Protein-protein Interactions for H2AFX
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DIS3L Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait C5orf64 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CETN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP19A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MACROD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEB10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PAIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SURF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF420 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in H2AFX
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Histone_H2A IPR002119 0.84
Category members Histone_core_D IPR007125 0.12
Category members Histone-fold IPR009072 0.01
Category members CBFA_NFYB_domain IPR003958 0


Protein complexes (CORUM database) featuring H2AFX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1223 H2AX complex, isolated from cells without IR exposure Database 8.51
Category members Corum 1227 H2AX complex II Database 7.93
Category members Corum 1226 H2AX complex I Database 1.58
Category members Corum 2774 MDC1-H2AFX-TP53BP1 complex Database 0.66
Category members Corum 3618 GammaH2AFX-NDHII-Ku70-DNA complex Database 0.06


Categories featuring H2AFX
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_1281 REACTOME_DEPOSITION_OF_NEW_CENPA_CONTAINING_NUCLEOSOMES_AT_THE_CENTROMERE 0 4.19
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006334 nucleosome assembly Database 3.77
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_1139 REACTOME_RNA_POL_I_PROMOTER_OPENING 0 3.56
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0000786 nucleosome Database 2.41
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0005657 replication fork Database 0.95
Category members GO Category GO:0042393 histone binding Database 0.94
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members Pathway Pathway_920 REACTOME_AMYLOIDS 0 0.68
Category members GO Category GO:0001741 XY body Database 0.47
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0001673 male germ cell nucleus Database 0.44
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0045739 positive regulation of DNA repair Database 0.04
Category members GO Category GO:0007126 meiosis Database 0.01
Category members GO Category GO:0007283 spermatogenesis Database 0


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