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Query: FANCA

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FANCA 1 3.450 -1.940 3.290
FANCA 1 3.450 -1.940 3.290 0.441

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FANCA Ubiquitylation K261 0.217 _TVEPEK(gl)MPQVTVDVLQR_
FANCA Ubiquitylation K1079 -0.322 _ELLMYK(gl)R_
FANCA Ubiquitylation K1387 -0.462 _SLELK(gl)GQAGQPR_
FANCA Ubiquitylation K249 -0.498 -0.588 _GFQK(gl)NSDLRR_
FANCA Ubiquitylation K608 -0.873 _VAFIESLK(gl)R_
FANCA Ubiquitylation K1199 -0.882 _ELQK(gl)LQEGR_
FANCA Ubiquitylation K44 -0.981 _LK(gl)ESAVR_

Background Information for FANCA:


Pubmed-FANCA »
Uniprot-FANCA »
Biogrid-FANCA »
ProteomicsDB-FANCA »

Tumorportal-FANCA »
COSMIC-FANCA »
GenomeRNAi-FANCA »
Genecards-FANCA


Protein-protein Interactions for FANCA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait APLNR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1orf86 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf118 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FANCG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IARS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NPY2R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FANCA
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring FANCA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 1152 FA complex (Fanconi anemia complex) Database 0
Category members Corum 1623 FA core complex 1 (Fanconi anemia core complex 1) Database 0
Category members Corum 1624 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 1625 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 245 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0
Category members Corum 3083 Nucleic and chromatin Fanconi complex Database 0
Category members Corum 91 FA complex (Fanconi anemia complex), cytoplasmic Database 0


Categories featuring FANCA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0008585 female gonad development Database 0.64
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members Disease phenotype FANCONI_ANEMIA_COMPLEMENTATION_GROUP_A FANCONI ANEMIA COMPLEMENTATION GROUP A Database 0.2
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0007140 male meiosis Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0043240 Fanconi anaemia nuclear complex Database 0


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