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REACTOME_FANCONI_ANEMIA_PATHWAY
(Pathway_812)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
FANCD2 5 -0.650 0.520 1.226 0.362 -0.007 1.535 0.808
RPS27A 4 -1.330 2.560 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180 -0.309 0.131 -0.009
UBA52 3 -1.260 2.180
BRCA1 2 0.200 -0.140 0.433 0.018 0.146
PALB2 1 -1.420 3.110
FANCL 1 -0.070 -0.020
USP1 1 2.430 -1.190
ATR 1 -1.040 0.920 0.671 1.041 0.708
FANCA 1 -1.940 3.290
FANCA 1 -1.940 3.290 0.441
UBE2T 0 0.090 0.230
FANCE 0 -0.390 0.490
ATM 0 0.398 0.474
FANCC 0 1.030 -0.520
FANCF 0 1.290 -1.060
FAAP100 0 -0.470 0.820 0.589 0.736
FANCG 0 0.390 -0.740 0.107 0.986

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ATM Ubiquitylation K307 -0.196 _GAYESTK(gl)WR_
ATM Ubiquitylation K331 -0.126 _GK(gl)YSSGFR_
ATM Ubiquitylation K385 -0.669 _ESSDYSVPCK(gl)R_
ATM Ubiquitylation K1101 -0.548 _LFQDTK(gl)GDSSR_
ATM Ubiquitylation K1109 -1.666 _LLK(gl)ALPLK_
ATM Ubiquitylation K1698 -1.026 _DASYTK(gl)ALK_
ATM Ubiquitylation K1738 -0.137 _SAAVTCLK(gl)NILATK_
ATM Ubiquitylation K2025 -1.497 _SIGEPDSLYGCGGGK(gl)MLQPITR_
ATR Ubiquitylation K32 -0.929 _ELGSATPEEYNTVVQK(gl)PR_
ATR Phosphorylation S435 0.516 0.284 _RLS(ph)SSLNPSK_
ATR Ubiquitylation K746 -1.823 _NLK(gl)ATSQHECSSSQLK_
ATR Ubiquitylation K1019 1.662 _TLGK(gl)QLNVNRR_
ATR Ubiquitylation K1600 -0.437 _FQALK(gl)AEK_
ATR Ubiquitylation K2106 -0.136 _AYEWEK(gl)AGR_
ATR Ubiquitylation K2604 0.657 1.118 _LQGVIK(gl)TR_
BRCA1 Phosphorylation S123 0.465 0.445 _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_
BRCA1 Phosphorylation S753 2.662 4.077 _VSNNAEDPKDLMLS(ph)GER_
BRCA1 Phosphorylation S1009 0.733 1.028 _KNLLEENFEEHSM(ox)S(ph)PER_
BRCA1 Phosphorylation S1546 1.821 2.105 _NYPS(ph)QEELIK_
BRCA1 Phosphorylation S1564 3.065 _VVDVEEQQLEES(ph)GPHDLTETSYLPR_
BRCA1 Phosphorylation S1664 1.120 _EKPELTAS(ph)TER_
FAAP100 Phosphorylation S667 -0.762 _APS(ph)PLGPTRDPVATFLETCR_
FANCA Ubiquitylation K44 -0.981 _LK(gl)ESAVR_
FANCA Ubiquitylation K249 -0.498 -0.588 _GFQK(gl)NSDLRR_
FANCA Ubiquitylation K261 0.217 _TVEPEK(gl)MPQVTVDVLQR_
FANCA Ubiquitylation K608 -0.873 _VAFIESLK(gl)R_
FANCA Ubiquitylation K1079 -0.322 _ELLMYK(gl)R_
FANCA Ubiquitylation K1199 -0.882 _ELQK(gl)LQEGR_
FANCA Ubiquitylation K1387 -0.462 _SLELK(gl)GQAGQPR_
FANCC Ubiquitylation K552 -0.114 _ELLK(gl)ELR_
FANCD2 Ubiquitylation K77 -0.288 _TGESQNQLAVDQIAFQK(gl)K_
FANCD2 Ubiquitylation K137 0.364 _LQDEEASMGASYSKSLIK(gl)_
FANCD2 Ubiquitylation K322 -0.535 _LQASQVK(gl)LK_
FANCD2 Ubiquitylation K324 -0.384 _LQASQVKLK(gl)_
FANCD2 Ubiquitylation K561 2.102 3.950 _K(gl)QLSSTVFKYK_
FANCD2 Phosphorylation S592 1.311 1.350 _SES(ph)PSLTQER_
FANCD2 Phosphorylation S717 2.435 3.130 _DGGPVTS(ph)QESGQK_
FANCD2 Phosphorylation S1401 -0.015 _S(ph)QNSQESTADESEDDMSSQASK_
FANCD2 Phosphorylation S1404 -0.348 _S(ph)QNSQESTADESEDDMSSQASK_
FANCD2 Phosphorylation S1412 -1.471 _SQNSQESTADES(ph)EDDM(ox)SSQASK_
FANCE Phosphorylation S249 -0.010 -0.066 _SLESLADGGSAS(ph)PIKDQPVMAVK_
FANCF Ubiquitylation K186 -1.299 _LQEVGK(gl)AEAERPAR_
FANCF Ubiquitylation K331 -2.113 _FQSLCQAPPPLKDK(gl)_
FANCG Ubiquitylation K28 -0.599 _QAK(gl)VAQNSGLTLR_
FANCG Ubiquitylation K504 -1.806 _ATPEEKEQGAAFNCEQGCK(gl)SDAALQQLR_
FANCL Ubiquitylation K22 -0.421 _SK(gl)TVYEGFISAQGR_
FANCL Ubiquitylation K49 2.798 _IVLPEDLQLK(gl)NAR_
PALB2 Phosphorylation S190 1.462 1.104 _NPARS(ph)PVTEIR_
PALB2 Phosphorylation S387 -1.951 _SLS(ph)LEATS(ph)PLSAEK_
PALB2 Phosphorylation S660 0.033 -0.373 _EGSCIFPEELS(ph)PK_
RPS27A Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
RPS27A Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
RPS27A Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
RPS27A Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
RPS27A Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
RPS27A Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
RPS27A Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
RPS27A Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
RPS27A Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
RPS27A Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
RPS27A Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
RPS27A Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
UBA52 Ubiquitylation K6 1.066 0.995 _MQIFVK(gl)TLTGK_
UBA52 Ubiquitylation K11 -0.488 -0.081 _TLTGK(gl)TITLEVEPSDTIENVKAK(gl)_
UBA52 Ubiquitylation K27 -0.882 -0.159 _TLTGK(gl)TITLEVEPSDTIENVK(gl)AK_
UBA52 Ubiquitylation K29 -1.087 -1.029 _AK(gl)IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K33 -0.736 -0.407 _IQDK(gl)EGIPPDQQR_
UBA52 Ubiquitylation K48 -0.062 0.315 _LIFAGK(gl)QLEDGRTLSDYNIQK_
UBA52 Phosphorylation S57 1.909 0.548 _TLS(ph)DYNIQK_
UBA52 Ubiquitylation K63 0.276 0.299 _TLSDYNIQK(gl)ESTLHLVLR_
UBA52 Ubiquitylation K93 0.181 2.418 _YNCDK(gl)MICR_
UBA52 Ubiquitylation K99 0.109 2.111 _VK(gl)LAVLK_
UBA52 Ubiquitylation K104 0.674 2.102 _LAVLK(gl)YYK_
UBA52 Ubiquitylation K107 2.949 3.611 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K113 1.572 3.672 _YYK(gl)VDENGK(gl)ISR_
UBA52 Ubiquitylation K152 4.747 4.970 _CCLTYCFNK(gl)PEDK_
UBA52 Ubiquitylation K156 4.809 _CCLTYCFNKPEDK(gl)_
UBE2T Ubiquitylation K91 -0.306 0.175 _ICLDVLK(gl)LPPK_
UBE2T Ubiquitylation K141 -0.260 _YNKPAFLK(gl)NAR_
UBE2T Ubiquitylation K192 -0.193 _ASQLVGIEKK(gl)_
USP1 Phosphorylation S42 1.055 _ALDFTDS(ph)QENEEK_
USP1 Phosphorylation S66 0.045 _ASEIDQVVPAAQS(ph)SPINCEK_
USP1 Phosphorylation S67 -0.170 0.304 _ASEIDQVVPAAQSS(ph)PINCEK_
USP1 Phosphorylation S475 -1.080 -0.086 _REDFQDISVPVQEDELSKVEESSEIS(ph)PEPK_
USP1 Ubiquitylation K689 0.173 -1.509 _ASNPDK(gl)VASTAFAENR_


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