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Query: FANCE

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FANCE 0 0.414 -0.390 0.490

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FANCE Phosphorylation S249 -0.010 -0.066 _SLESLADGGSAS(ph)PIKDQPVMAVK_

Background Information for FANCE:


Pubmed-FANCE »
Uniprot-FANCE »
Biogrid-FANCE »
ProteomicsDB-FANCE »

Tumorportal-FANCE »
COSMIC-FANCE »
GenomeRNAi-FANCE »
Genecards-FANCE


Protein-protein Interactions for FANCE
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FANCE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FANCE
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring FANCE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 1152 FA complex (Fanconi anemia complex) Database 0
Category members Corum 1623 FA core complex 1 (Fanconi anemia core complex 1) Database 0
Category members Corum 1624 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 1625 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 245 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0
Category members Corum 3083 Nucleic and chromatin Fanconi complex Database 0


Categories featuring FANCE
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members GO Category GO:0003674 molecular_function Database 0.08
Category members GO Category GO:0043240 Fanconi anaemia nuclear complex Database 0


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