bioLOGIC-db

bioLOGIC Data

Query: FANCD2

This is a cancer-associated gene according to the Sanger cancer gene census.

[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
FANCD2	5	16.060	-0.650	0.520	1.226	0.362	-0.007	1.535	0.808

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
FANCD2	Ubiquitylation	K561	2.102	3.950	_K(gl)QLSSTVFKYK_
FANCD2	Phosphorylation	S717	2.435	3.130	_DGGPVTS(ph)QESGQK_
FANCD2	Phosphorylation	S592	1.311	1.350	_SES(ph)PSLTQER_
FANCD2	Ubiquitylation	K137		0.364	_LQDEEASMGASYSKSLIK(gl)_
FANCD2	Phosphorylation	S1401		-0.015	_S(ph)QNSQESTADESEDDMSSQASK_
FANCD2	Ubiquitylation	K77		-0.288	_TGESQNQLAVDQIAFQK(gl)K_
FANCD2	Phosphorylation	S1404		-0.348	_S(ph)QNSQESTADESEDDMSSQASK_
FANCD2	Ubiquitylation	K324		-0.384	_LQASQVKLK(gl)_
FANCD2	Ubiquitylation	K322		-0.535	_LQASQVK(gl)LK_
FANCD2	Phosphorylation	S1412	-1.471		_SQNSQESTADES(ph)EDDM(ox)SSQASK_

ProteomicsDB-FANCD2 »

Protein-protein Interactions for FANCD2

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait BAG6;BAT3	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait CDC42	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait CNTROB	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait EMC2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait EPHA2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait HNRNPD	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ITGB3BP	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait JRKL	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PIGS	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait SKP1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait YEATS4	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait ALDH3A2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait LPAR4	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in FANCD2

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	ARM-type_fold	IPR016024	9.26

Protein complexes (CORUM database) featuring FANCD2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	2217	MDC1-MRN-ATM-FANCD2 complex	Database	1.08

Categories featuring FANCD2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005654	nucleoplasm	Database	INF
Category members	GO Category	GO:0006281	DNA repair	Database	INF
Category members	GO Category	GO:0005488	binding	Database	9.32
Category members	Pathway	Pathway_338	REACTOME_DNA_REPAIR	0	8.18
Category members	Human mutations	Sanger_cancer_genes	Sanger cancer genes	Database	4.88
Category members	Pathway	Pathway_978	PID_ATM_PATHWAY	0	4.31
Category members	GO Category	GO:0006974	cellular response to DNA damage stimulus	Database	3.57
Category members	Pathway	Pathway_865	PID_ATR_PATHWAY	0	3.46
Category members	Pathway	Pathway_870	PID_BARD1_PATHWAY	0	2.44
Category members	GO Category	GO:0000793	condensed chromosome	Database	1.32
Category members	Pathway	Pathway_873	PID_FANCONI_PATHWAY	0	1.09
Category members	Pathway	Pathway_979	BIOCARTA_ATRBRCA_PATHWAY	0	0.6
Category members	GO Category	GO:0010332	response to gamma radiation	Database	0.52
Category members	Pathway	Pathway_829	REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY	0	0.38
Category members	Pathway	Pathway_812	REACTOME_FANCONI_ANEMIA_PATHWAY	0	0.29
Category members	Disease phenotype	Fanconi_anemia	Fanconi anemia	Database	0.26
Category members	GO Category	GO:0007129	synapsis	Database	0
Category members	GO Category	GO:0007276	gamete generation	Database	0