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Query: ATR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATR 1 6.920 -1.040 0.920 0.671 1.041 0.708

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATR Ubiquitylation K2604 0.657 1.118 _LQGVIK(gl)TR_
ATR Phosphorylation S435 0.516 0.284 _RLS(ph)SSLNPSK_
ATR Ubiquitylation K2106 -0.136 _AYEWEK(gl)AGR_
ATR Ubiquitylation K32 -0.929 _ELGSATPEEYNTVVQK(gl)PR_
ATR Ubiquitylation K746 -1.823 _NLK(gl)ATSQHECSSSQLK_
ATR Ubiquitylation K1019 1.662 _TLGK(gl)QLNVNRR_
ATR Ubiquitylation K1600 -0.437 _FQALK(gl)AEK_

Background Information for ATR:


Pubmed-ATR »
Uniprot-ATR »
Biogrid-ATR »
ProteomicsDB-ATR »

Tumorportal-ATR »
COSMIC-ATR »
GenomeRNAi-ATR »
Genecards-ATR


Protein-protein Interactions for ATR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ALDH3A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATRIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CA14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD274 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CEACAM21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKFZp686O24166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OPRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PVR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCARA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCN3B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VASN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ATR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members PI3/4_kinase_cat_dom IPR000403 1.52
Category members HEAT_type_2 IPR021133 0.74
Category members FATC IPR003152 0.68
Category members PIK_FAT IPR014009 0.68
Category members PIK-rel_kinase_FAT IPR003151 0.16
Category members Kinase-like_dom IPR011009 0.03


Protein complexes (CORUM database) featuring ATR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1134 ATR-HDAC2-CHD4 complex Database 0.77
Category members Corum 1133 ATR-HDAC2 complex Database 0.35
Category members Corum 265 ATR-ATRIP complex Database 0.33


Categories featuring ATR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032405 MutLalpha complex binding Database 1.47
Category members GO Category GO:0016605 PML body Database 1.41
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members GO Category GO:0001741 XY body Database 0.47
Category members Pathway Pathway_829 REACTOME_REGULATION_OF_THE_FANCONI_ANEMIA_PATHWAY 0 0.38
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members Disease phenotype Seckel_syndrome Seckel syndrome Database 0.25
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_1248 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0008156 negative regulation of DNA replication Database 0.03
Category members Pathway Pathway_1249 PID_CIRCADIAN_PATHWAY 0 0
Category members Pathway Pathway_593 PID_TCPTP_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0032407 MutSalpha complex binding Database 0
Category members GO Category GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator Database 0


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