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Query: FANCL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FANCL 1 2.778 -0.070 -0.020

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FANCL Ubiquitylation K49 2.798 _IVLPEDLQLK(gl)NAR_
FANCL Ubiquitylation K22 -0.421 _SK(gl)TVYEGFISAQGR_

Background Information for FANCL:


Pubmed-FANCL »
Uniprot-FANCL »
Biogrid-FANCL »
ProteomicsDB-FANCL »

Tumorportal-FANCL »
COSMIC-FANCL »
GenomeRNAi-FANCL »
Genecards-FANCL


Protein-protein Interactions for FANCL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FANCL Cat. description Hein, Mann, Cell 2015
Category members IP bait CLEC2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL6R Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FANCL
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring FANCL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 1152 FA complex (Fanconi anemia complex) Database 0
Category members Corum 1624 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 245 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0


Categories featuring FANCL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0007276 gamete generation Database 0
Category members GO Category GO:0016874 ligase activity Database 0
Category members GO Category GO:0043240 Fanconi anaemia nuclear complex Database 0


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