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Query: PALB2

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PALB2 1 5.676 -1.420 3.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PALB2 Phosphorylation S190 1.462 1.104 _NPARS(ph)PVTEIR_
PALB2 Phosphorylation S660 0.033 -0.373 _EGSCIFPEELS(ph)PK_
PALB2 Phosphorylation S387 -1.951 _SLS(ph)LEATS(ph)PLSAEK_

Background Information for PALB2:


Pubmed-PALB2 »
Uniprot-PALB2 »
Biogrid-PALB2 »
ProteomicsDB-PALB2 »

Tumorportal-PALB2 »
COSMIC-PALB2 »
GenomeRNAi-PALB2 »
Genecards-PALB2


Protein-protein Interactions for PALB2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MORF4L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MORF4L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PALB2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39


Protein complexes (CORUM database) featuring PALB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PALB2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Disease phenotype BREAST_CANCER BREAST CANCER Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0007498 mesoderm development Database 0.58
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members Disease phenotype FANCONI_ANEMIA_COMPLEMENTATION_GROUP_A FANCONI ANEMIA COMPLEMENTATION GROUP A Database 0.2
Category members Disease phenotype Familial_pancreatic_carcinoma Familial pancreatic carcinoma Database 0.06
Category members GO Category GO:0001756 somitogenesis Database 0
Category members GO Category GO:0001833 inner cell mass cell proliferation Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0036342 post-anal tail morphogenesis Database 0


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