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Query: FANCC

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FANCC 0 -0.114 1.030 -0.520

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FANCC Ubiquitylation K552 -0.114 _ELLK(gl)ELR_

Background Information for FANCC:


Pubmed-FANCC »
Uniprot-FANCC »
Biogrid-FANCC »
ProteomicsDB-FANCC »

Tumorportal-FANCC »
COSMIC-FANCC »
GenomeRNAi-FANCC »
Genecards-FANCC


Protein-protein Interactions for FANCC
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in FANCC
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring FANCC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 1152 FA complex (Fanconi anemia complex) Database 0
Category members Corum 1623 FA core complex 1 (Fanconi anemia core complex 1) Database 0
Category members Corum 1624 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 1625 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 245 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0
Category members Corum 3083 Nucleic and chromatin Fanconi complex Database 0
Category members Corum 91 FA complex (Fanconi anemia complex), cytoplasmic Database 0


Categories featuring FANCC
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0002262 myeloid cell homeostasis Database 0.3
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members GO Category GO:0007276 gamete generation Database 0
Category members GO Category GO:0007281 germ cell development Database 0
Category members GO Category GO:0019430 removal of superoxide radicals Database 0
Category members GO Category GO:0043240 Fanconi anaemia nuclear complex Database 0


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