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Query: FANCG

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FANCG 0 0.494 0.390 -0.740 0.107 0.986

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FANCG Ubiquitylation K28 -0.599 _QAK(gl)VAQNSGLTLR_
FANCG Ubiquitylation K504 -1.806 _ATPEEKEQGAAFNCEQGCK(gl)SDAALQQLR_

Background Information for FANCG:


Pubmed-FANCG »
Uniprot-FANCG »
Biogrid-FANCG »
ProteomicsDB-FANCG »

Tumorportal-FANCG »
COSMIC-FANCG »
GenomeRNAi-FANCG »
Genecards-FANCG


Protein-protein Interactions for FANCG
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC132 Cat. description Hein, Mann, Cell 2015
Category members IP bait KAT8 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF15 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF1B Cat. description Hein, Mann, Cell 2015
Category members IP bait C1orf86 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPEP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FANCG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GYPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FANCG
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TPR_repeat IPR019734 0.93
Category members Sig_transdc_His_kin_Hpt_dom IPR008207 0


Protein complexes (CORUM database) featuring FANCG
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 1152 FA complex (Fanconi anemia complex) Database 0
Category members Corum 1623 FA core complex 1 (Fanconi anemia core complex 1) Database 0
Category members Corum 1624 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 1625 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 245 FA core complex (Fanconi anemia core complex) Database 0
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0
Category members Corum 3083 Nucleic and chromatin Fanconi complex Database 0
Category members Corum 91 FA complex (Fanconi anemia complex), cytoplasmic Database 0


Categories featuring FANCG
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members Pathway Pathway_812 REACTOME_FANCONI_ANEMIA_PATHWAY 0 0.29
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members GO Category GO:0000160 phosphorelay signal transduction system Database 0.19
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members GO Category GO:0000075 cell cycle checkpoint Database 0
Category members GO Category GO:0001541 ovarian follicle development Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0007005 mitochondrion organization Database 0
Category members GO Category GO:0007286 spermatid development Database 0
Category members GO Category GO:0043240 Fanconi anaemia nuclear complex Database 0


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