bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: BLM

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BLM 0 0.687 1.270 -0.830
BLM 0 0.687 1.270 -0.830 -0.850 -0.141 0.144 0.151 0.149

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BLM Phosphorylation S144 1.234 _KLEFSSS(ph)PDSLSTINDWDDMDDFDTSETSK_

Background Information for BLM:


Pubmed-BLM »
Uniprot-BLM »
Biogrid-BLM »
ProteomicsDB-BLM »

Tumorportal-BLM »
COSMIC-BLM »
GenomeRNAi-BLM »
Genecards-BLM


Protein-protein Interactions for BLM
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BLM Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait C16orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MECP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF512 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BLM
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members DNA_helicase_ATP-dep_RecQ IPR004589 0.25
Category members HRDC-like IPR010997 0.17
Category members RQC_domain IPR018982 0.11
Category members HRDC_dom IPR002121 0


Protein complexes (CORUM database) featuring BLM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 5197 PTIP-DNA damage response complex Database 0.94
Category members Corum 434 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) Database 0.83
Category members Corum 2222 BLM complex II Database 0.3
Category members Corum 2738 BLM complex II Database 0.3
Category members Corum 244 BRAFT complex Database 0.29
Category members Corum 248 BRAFT complex Database 0.27
Category members Corum 2228 BLM-RAD51L3-XRCC2 complex Database 0.17
Category members Corum 1218 BLM-TRF2 complex Database 0.05
Category members Corum 2223 BLM-TOP3A complex Database 0.05
Category members Corum 246 BLM complex III Database 0.01
Category members Corum 2224 MSH2/6-BLM-p53-RAD51 complex Database 0
Category members Corum 2739 FA complex (Fanconi anemia complex) Database 0


Categories featuring BLM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members GO Category GO:0003697 single-stranded DNA binding Database 4.24
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0016605 PML body Database 1.41
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0009378 four-way junction helicase activity Database 1.06
Category members GO Category GO:0005657 replication fork Database 0.95
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0001673 male germ cell nucleus Database 0.44
Category members GO Category GO:0000405 bubble DNA binding Database 0.4
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0045910 negative regulation of DNA recombination Database 0.31
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0045120 pronucleus Database 0.27
Category members GO Category GO:0043140 ATP-dependent 3'-5' DNA helicase activity Database 0.25
Category members GO Category GO:0046641 positive regulation of alpha-beta T cell proliferation Database 0.21
Category members GO Category GO:0051782 negative regulation of cell division Database 0.17
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members GO Category GO:0051880 G-quadruplex DNA binding Database 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0045950 negative regulation of mitotic recombination Database 0.05
Category members GO Category GO:0036310 annealing helicase activity Database 0.01
Category members GO Category GO:0000085 mitotic G2 phase Database 0
Category members GO Category GO:0000729 DNA double-strand break processing Database 0
Category members GO Category GO:0000733 DNA strand renaturation Database 0
Category members GO Category GO:0000800 lateral element Database 0
Category members GO Category GO:0031297 replication fork processing Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0
Category members GO Category GO:0046632 alpha-beta T cell differentiation Database 0
Category members GO Category GO:0048478 replication fork protection Database 0
Category members GO Category GO:0051098 regulation of binding Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0070244 negative regulation of thymocyte apoptotic process Database 0


.

© Copyright Svejstrup Laboratory 2015