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Query: RFC4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RFC4 0 -0.536 1.100 -0.890 -0.721 -0.389 0.425 -0.194 0.037

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RFC4 Ubiquitylation K205 0.306 _FKPLSDK(gl)IQQQR_
RFC4 Ubiquitylation K217 -0.818 _LLDIAKK(gl)_
RFC4 Ubiquitylation K240 0.204 _K(gl)AITFLQSATR_

Background Information for RFC4:


Pubmed-RFC4 »
Uniprot-RFC4 »
Biogrid-RFC4 »
ProteomicsDB-RFC4 »

Tumorportal-RFC4 »
COSMIC-RFC4 »
GenomeRNAi-RFC4 »
Genecards-RFC4


Protein-protein Interactions for RFC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPU Cat. description Hein, Mann, Cell 2015
Category members IP bait IBTK Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP56 Cat. description Hein, Mann, Cell 2015
Category members IP bait PCNA Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SRP72 Cat. description Hein, Mann, Cell 2015
Category members IP bait DSCC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD17 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RFC4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members AAA+_ATPase IPR003593 0.38
Category members Rep_factorC_C_dom IPR013748 0.22
Category members ATPase_AAA_core IPR003959 0.14
Category members DUF815 IPR008533 0.04
Category members DNA_pol3_clamp-load_cplx_C IPR008921 0


Protein complexes (CORUM database) featuring RFC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 434 BASC (Ab 80) complex (BRCA1-associated genome surveillance complex) Database 0.83
Category members Corum 435 BASC (Ab 81) complex (BRCA1-associated genome surveillance complex) Database 0.23
Category members Corum 3070 CTF18-cohesion-RFC-POLH complex Database 0.17
Category members Corum 278 RFC core complex Database 0.02
Category members Corum 1003 RC complex (Replication competent complex) Database 0
Category members Corum 1132 RFC2-RIalpha complex Database 0
Category members Corum 2199 CTF18-RFC subcomplex Database 0
Category members Corum 2200 RFC2-5 subcomplex Database 0
Category members Corum 2201 PCNA-RFC2-5 complex Database 0
Category members Corum 2202 CHL12-RFC2-5 complex Database 0
Category members Corum 2203 BRD4-RFC complex Database 0
Category members Corum 266 RAD17-RFC complex Database 0
Category members Corum 268 Checkpoint Rad complex Database 0
Category members Corum 270 RAD17-RFC complex Database 0
Category members Corum 274 RAD17-RFC-9-1-1 checkpoint supercomplex Database 0
Category members Corum 277 RFC complex Database 0
Category members Corum 279 RFC complex (activator A 1 complex) Database 0
Category members Corum 2797 PCNA-CHL12-RFC2-5 complex Database 0
Category members Corum 2799 RFC complex Database 0
Category members Corum 2804 CTF18-cohesion-RFC complex Database 0
Category members Corum 2810 Rad17-RFC complex Database 0


Categories featuring RFC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0006289 nucleotide-excision repair Database 6.65
Category members GO Category GO:0006283 transcription-coupled nucleotide-excision repair Database 6.58
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_342 REACTOME_NUCLEOTIDE_EXCISION_REPAIR 0 5.83
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_336 REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 0 4.6
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_344 REACTOME_GLOBAL_GENOMIC_NER_GG_NER 0 3.29
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_341 KEGG_MISMATCH_REPAIR 0 1.02
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members GO Category GO:0006297 nucleotide-excision repair, DNA gap filling Database 0.25
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members Pathway Pathway_333 REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER 0 0.08
Category members Pathway Pathway_314 REACTOME_POL_SWITCHING 0 0
Category members GO Category GO:0005663 DNA replication factor C complex Database 0


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