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Query: FBXW11

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
FBXW11 0 -0.091 -0.780 0.530 0.532 -1.791 0.313

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
FBXW11 Ubiquitylation K466 0.325 _IVSGAYDGKIK(gl)_

Background Information for FBXW11:


Pubmed-FBXW11 »
Uniprot-FBXW11 »
Biogrid-FBXW11 »
ProteomicsDB-FBXW11 »

Tumorportal-FBXW11 »
COSMIC-FBXW11 »
GenomeRNAi-FBXW11 »
Genecards-FBXW11


Protein-protein Interactions for FBXW11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC25B Cat. description Hein, Mann, Cell 2015
Category members IP bait FBXW11 Cat. description Hein, Mann, Cell 2015
Category members IP bait RASSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SKP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APBA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC25A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC25B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COBL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR161 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KHDRBS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LSP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFKBIA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUAK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUAK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PLEKHG5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRICKLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3BP5L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPANXN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPATA20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TACC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TFAP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSC22D4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBTB46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF704 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in FBXW11
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members G-protein_beta_WD-40_rep IPR020472 0.12
Category members Beta-TrCP_D IPR021977 0.08
Category members F-box_dom IPR001810 0


Protein complexes (CORUM database) featuring FBXW11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5233 TNF-alpha/NF-kappa B signaling complex 5 Database 0.29
Category members Corum 2187 Ubiquitin E3 ligase (NFKBIA, FBXW11, BTRC, CUL1, SKP1A) Database 0.2
Category members Corum 1052 Ubiquitin E3 ligase (FBXW11, SKP1A, CUL1, RBX1) Database 0.04
Category members Corum 2725 Ubiquitin E3 ligase (NFKBIA, FBXW11, CUL1, SKP1A) Database 0.04


Categories featuring FBXW11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0019005 SCF ubiquitin ligase complex Database 0.09
Category members GO Category GO:0042753 positive regulation of circadian rhythm Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Database 0.05
Category members GO Category GO:0042347 negative regulation of NF-kappaB import into nucleus Database 0.04
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0031648 protein destabilization Database 0
Category members GO Category GO:0045862 positive regulation of proteolysis Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048511 rhythmic process Database 0


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