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Query: BRIP1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BRIP1 1 2.599 0.650 -0.340

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BRIP1 Phosphorylation S112 0.807 1.459 _HFNYPS(ph)TPPSER_
BRIP1 Phosphorylation S1237 0.424 0.355 _NFKPS(ph)PSK_
BRIP1 Ubiquitylation K797 -0.723 0.188 _DLQVELK(gl)R_
BRIP1 Phosphorylation S206 -0.381 _INSFS(ph)PQKPPGHCSR_
BRIP1 Ubiquitylation K764 -0.462 _GK(gl)VSEGLDFSDDNAR_
BRIP1 Phosphorylation S1032 -0.789 -0.532 _ATPELGSSENSASS(ph)PPR_
BRIP1 Phosphorylation T113 1.675 _HFNYPST(ph)PPSER_

Background Information for BRIP1:


Pubmed-BRIP1 »
Uniprot-BRIP1 »
Biogrid-BRIP1 »
ProteomicsDB-BRIP1 »

Tumorportal-BRIP1 »
COSMIC-BRIP1 »
GenomeRNAi-BRIP1 »
Genecards-BRIP1


Protein-protein Interactions for BRIP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PMS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AVIL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRTAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CRYL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DOCK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FHL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GFOD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIPH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD51L3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SGK196 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWA5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BRIP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_ATP-bd IPR014001 2.48
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members Helicase-like_DEXD_c2 IPR006554 0.06
Category members ATP-dep_Helicase_C IPR006555 0.06
Category members DEAD_2 IPR010614 0.06
Category members DNA_helicase_DNA-repair_Rad3 IPR013020 0.06
Category members Helic_SF1/SF2_ATP-bd_DinG/Rad3 IPR014013 0.06
Category members TIL_dom IPR002919 0


Protein complexes (CORUM database) featuring BRIP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 242 BRCA1-BACH1 complex Database 0.28


Categories featuring BRIP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0000077 DNA damage checkpoint Database 2.04
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members Disease phenotype BREAST_CANCER BREAST CANCER Database 0.62
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Disease phenotype Fanconi_anemia Fanconi anemia Database 0.26
Category members Disease phenotype FANCONI_ANEMIA_COMPLEMENTATION_GROUP_A FANCONI ANEMIA COMPLEMENTATION GROUP A Database 0.2
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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