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Query: MRE11A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MRE11A 0 1.633 1.600 -0.730 0.145 0.420
MRE11A 0 1.633 1.600 -0.730 0.023 0.453 0.150

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MRE11A Ubiquitylation K387 0.442 _FSQK(gl)FVDR_

Background Information for MRE11A:


Pubmed-MRE11A »
Uniprot-MRE11A »
Biogrid-MRE11A »
ProteomicsDB-MRE11A »

Tumorportal-MRE11A »
COSMIC-MRE11A »
GenomeRNAi-MRE11A »
Genecards-MRE11A


Protein-protein Interactions for MRE11A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB32 Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBGCP6 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RGS20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MRE11A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring MRE11A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1193 Rap1 complex Database 2.66
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57
Category members Corum 1189 DNA double-strand break end-joining complex Database 2.16
Category members Corum 433 BASC complex (BRCA1-associated genome surveillance complex) Database 1.74
Category members Corum 2815 BRCA1-BARD1-BACH1-DNA damage complex II Database 1.57
Category members Corum 2766 TERF2-RAP1 complex Database 1.52
Category members Corum 202 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 2218 MDC1-MRE11-RAD50-NBS1 complex Database 1.09
Category members Corum 619 MRE11A-RAD50-NBN-TRF2 complex Database 1.09
Category members Corum 627 MRN-TRRAP complex (MRE11A-RAD50-NBN-TRRAP complex) Database 1.09
Category members Corum 964 BRCA1-RAD50-MRE11-NBS1 complex Database 1.09
Category members Corum 2217 MDC1-MRN-ATM-FANCD2 complex Database 1.08
Category members Corum 5197 PTIP-DNA damage response complex Database 0.94
Category members Corum 1081 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 173 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 2767 RAD50-MRE11-NBN-p200-p350 complex Database 0.62
Category members Corum 331 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 618 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 71 MRN complex (MRE11-RAD50-NBS1 complex) Database 0.62
Category members Corum 73 MRN complex (MRE11-RAD50-NBN complex) Database 0.62
Category members Corum 972 MRN complex (MRE11-RAD50-NBS1 complex) Database 0.62
Category members Corum 263 R/M complex (RAD50-MRE11 complex) Database 0.25
Category members Corum 264 R/M complex (RAD50-MRE11 complex) Database 0.25
Category members Corum 72 R/M complex (RAD50-MRE11 complex) Database 0.25


Categories featuring MRE11A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_862 REACTOME_HOMOLOGOUS_RECOMBINATION_REPAIR_OF_REPLICATION_INDEPENDENT_DOUBLE_STRAND_BREAKS 0 3
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0030870 Mre11 complex Database 1.75
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members Disease phenotype Hereditary_breast_and_ovarian_cancer_syndrome Hereditary breast and ovarian cancer syndrome Database 1.23
Category members GO Category GO:0031573 intra-S DNA damage checkpoint Database 1.18
Category members Pathway Pathway_873 PID_FANCONI_PATHWAY 0 1.09
Category members GO Category GO:0032876 negative regulation of DNA endoreduplication Database 1.09
Category members GO Category GO:0007004 telomere maintenance via telomerase Database 0.98
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members GO Category GO:0007062 sister chromatid cohesion Database 0.69
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0035861 site of double-strand break Database 0.65
Category members Pathway Pathway_979 BIOCARTA_ATRBRCA_PATHWAY 0 0.6
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members Pathway Pathway_860 KEGG_NON_HOMOLOGOUS_END_JOINING 0 0.52
Category members Pathway Pathway_980 BIOCARTA_ATM_PATHWAY 0 0.46
Category members GO Category GO:0033674 positive regulation of kinase activity Database 0.3
Category members GO Category GO:0000019 regulation of mitotic recombination Database 0.25
Category members GO Category GO:0000014 single-stranded DNA endodeoxyribonuclease activity Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members Pathway Pathway_343 KEGG_HOMOLOGOUS_RECOMBINATION 0 0.12
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0004518 nuclease activity Database 0.09
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0007126 meiosis Database 0.01
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members GO Category GO:0000075 cell cycle checkpoint Database 0
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0004520 endodeoxyribonuclease activity Database 0
Category members GO Category GO:0004527 exonuclease activity Database 0
Category members GO Category GO:0006259 DNA metabolic process Database 0
Category members GO Category GO:0007095 mitotic G2 DNA damage checkpoint Database 0
Category members GO Category GO:0007129 synapsis Database 0
Category members GO Category GO:0007131 reciprocal meiotic recombination Database 0
Category members GO Category GO:0008408 3'-5' exonuclease activity Database 0
Category members GO Category GO:0030145 manganese ion binding Database 0
Category members GO Category GO:0031954 positive regulation of protein autophosphorylation Database 0


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