Results for the Category
3'-5' exonuclease activity
(GO:0008408)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| RAD50 | 3 | 0.350 | -0.420 | 0.165 | 0.571 | 0.509 | 0.691 | 0.587 |
| EXD2 | 1 | 2.260 | -1.080 | 0.345 | -0.005 | |||
| RAD9A | 1 | -2.070 | 3.350 | |||||
| MRE11A | 0 | 1.600 | -0.730 | 0.145 | 0.420 | |||
| MRE11A | 0 | 1.600 | -0.730 | 0.023 | 0.453 | 0.150 | ||
| POLD1 | 0 | 1.600 | -1.300 | -0.932 | 0.362 | 0.283 | ||
| POLD1 | 0 | 1.600 | -1.300 | |||||
| APEX1 | 0 | 0.630 | -0.180 | -0.057 | -0.077 | |||
| POLA1 | 0 | 0.720 | -0.610 | 0.594 | 0.355 | 0.027 | ||
| ERI1 | 0 | -0.350 | 0.290 | |||||
| RAD1 | 0 | 0.550 | 0.120 | |||||
| WRN | 0 | -0.320 | -0.170 | 0.180 | ||||
| EXOSC10 | 0 | 0.160 | -0.170 | -0.327 | -0.108 | -0.734 | -0.003 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| APEX1 | Ubiquitylation | K25 | -0.227 | _GAVAEDGDELRTEPEAKK(gl)_ | |
| APEX1 | Ubiquitylation | K58 | -0.215 | _TSPSGK(gl)PATLK_ | |
| ERI1 | Ubiquitylation | K92 | 0.194 | _LSEFK(gl)LETR_ | |
| EXOSC10 | Ubiquitylation | K591 | -1.148 | _SEVAAGVK(gl)K_ | |
| EXOSC10 | Ubiquitylation | K592 | -1.148 | _SEVAAGVK(gl)K_ | |
| EXOSC10 | Ubiquitylation | K680 | -1.926 | _GPLTVAQKK(gl)_ | |
| EXOSC10 | Ubiquitylation | K710 | -1.867 | _APVSQAAK(gl)FDPSTK_ | |
| EXOSC10 | Ubiquitylation | K716 | -2.215 | _FDPSTK(gl)IYEISNR_ | |
| MRE11A | Ubiquitylation | K387 | 0.442 | _FSQK(gl)FVDR_ | |
| POLA1 | Phosphorylation | S192 | -0.049 | -0.187 | _S(ph)IGASPNPFSVHTATAVPSGK_ |
| POLA1 | Phosphorylation | S196 | -0.374 | _RSIGAS(ph)PNPFSVHTATAVPSGK_ | |
| POLA1 | Ubiquitylation | K1120 | -0.317 | _DTIVENIQK(gl)R_ | |
| POLD1 | Ubiquitylation | K414 | -1.315 | _AQTLK(gl)VQTFPFLGR_ | |
| POLD1 | Ubiquitylation | K439 | -1.108 | _DSSFQSK(gl)QTGRR_ | |
| POLD1 | Ubiquitylation | K447 | -1.286 | _DTK(gl)VVSMVGR_ | |
| POLD1 | Ubiquitylation | K554 | -0.798 | _GQQVK(gl)VVSQLLR_ | |
| POLD1 | Ubiquitylation | K674 | -1.082 | -1.843 | _TPTGDEFVK(gl)TSVR_ |
| POLD1 | Ubiquitylation | K758 | -0.638 | _TK(gl)QLVESK_ | |
| POLD1 | Ubiquitylation | K853 | -0.080 | -1.776 | _MDCK(gl)GLEAVR_ |
| POLD1 | Ubiquitylation | K911 | -0.089 | -0.915 | _IDISQLVITK(gl)ELTR_ |
| POLD1 | Ubiquitylation | K923 | -2.496 | _AASDYAGK(gl)QAHVELAER_ | |
| POLD1 | Ubiquitylation | K1033 | 0.475 | -0.930 | _VGGLLAFAK(gl)R_ |
| POLD1 | Ubiquitylation | K1065 | -0.208 | _ESELYQK(gl)EVSHLNALEER_ | |
| RAD1 | Ubiquitylation | K46 | 0.748 | _EHATCFATK(gl)NGIK_ | |
| RAD50 | Ubiquitylation | K62 | -1.069 | _YICTGDFPPGTK(gl)GNTFVHDPK_ | |
| RAD50 | Phosphorylation | S635 | 2.474 | 3.050 | _LFDVCGS(ph)QDFESDLDR_ |
| RAD50 | Ubiquitylation | K753 | 0.394 | 0.397 | _NK(gl)LQNVNR_ |
| RAD50 | Ubiquitylation | K933 | 0.397 | _FQQEKEELINKK(gl)_ | |
| RAD50 | Ubiquitylation | K1068 | 0.098 | _LEENIDNIK(gl)R_ | |
| RAD50 | Ubiquitylation | K1178 | -0.548 | _SDADENVSASDK(gl)RR_ | |
| RAD50 | Ubiquitylation | K1285 | 2.195 | _SEYVEK(gl)FYR_ | |
| RAD9A | Phosphorylation | S277 | -0.249 | -0.052 | _DSLLDGHFVLATLSDTDSHSQDLGS(ph)PER_ |
| WRN | Ubiquitylation | K134 | 0.717 | _MLLENKAVK(gl)_ | |
| WRN | Phosphorylation | S1133 | 0.363 | 0.023 | _SIMVQS(ph)PEK_ |
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