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Query: POLA1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLA1 0 -0.171 0.720 -0.610 0.594 0.355 0.027

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLA1 Phosphorylation S192 -0.049 -0.187 _S(ph)IGASPNPFSVHTATAVPSGK_
POLA1 Ubiquitylation K1120 -0.317 _DTIVENIQK(gl)R_
POLA1 Phosphorylation S196 -0.374 _RSIGAS(ph)PNPFSVHTATAVPSGK_

Background Information for POLA1:


Pubmed-POLA1 »
Uniprot-POLA1 »
Biogrid-POLA1 »
ProteomicsDB-POLA1 »

Tumorportal-POLA1 »
COSMIC-POLA1 »
GenomeRNAi-POLA1 »
Genecards-POLA1


Protein-protein Interactions for POLA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRIM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA-dir_DNA_pol_B_exonuc IPR006133 0
Category members DNA-dir_DNA_pol_B_multi_dom IPR006134 0
Category members DNA-dir_DNA_pol_B IPR006172 0
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring POLA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1004 RC complex during S-phase of cell cycle Database 0.79
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 1098 DNA synthesome complex (13 subunits) Database 0.35
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1003 RC complex (Replication competent complex) Database 0
Category members Corum 1100 DNA polymerase alpha-primase complex Database 0
Category members Corum 1107 DNA synthesome core complex Database 0
Category members Corum 1108 DNA synthesome complex (15 subunits) Database 0


Categories featuring POLA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000785 chromatin Database 2.59
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members GO Category GO:0000722 telomere maintenance via recombination Database 0.64
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0032201 telomere maintenance via semi-conservative replication Database 0.35
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members Pathway Pathway_324 REACTOME_EXTENSION_OF_TELOMERES 0 0.33
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_311 REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 0 0.2
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members Pathway Pathway_316 REACTOME_LAGGING_STRAND_SYNTHESIS 0 0.11
Category members Pathway Pathway_312 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 0 0.11
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0019985 translesion synthesis Database 0.05
Category members Pathway Pathway_314 REACTOME_POL_SWITCHING 0 0
Category members GO Category GO:0000084 mitotic S phase Database 0
Category members GO Category GO:0001882 nucleoside binding Database 0
Category members GO Category GO:0003887 DNA-directed DNA polymerase activity Database 0
Category members GO Category GO:0003896 DNA primase activity Database 0
Category members GO Category GO:0005658 alpha DNA polymerase:primase complex Database 0
Category members GO Category GO:0006269 DNA replication, synthesis of RNA primer Database 0
Category members GO Category GO:0006273 lagging strand elongation Database 0
Category members GO Category GO:0008408 3'-5' exonuclease activity Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051539 4 iron, 4 sulfur cluster binding Database 0


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