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Results for the Category
REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX
(Pathway_318)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
W

Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPA1 6 0.500 0.350 3.133 3.046 0.303 1.770 2.112
RPA3 3 -0.760 1.900 1.805
RPA2 3 -1.830 3.700 1.524
RPA2 3 -1.830 3.700 2.592
MCM2 2 0.740 -0.140 0.552 0.052
MCM2 2 0.740 -0.140 1.288
MCM2 2 0.740 -0.140
MCM6 2 -0.170 -0.180 1.067 0.473 -0.065
POLE2 1 2.560 -1.150
MCM3 1 -1.860 3.650 1.197 0.554 0.207
CDT1 1 -0.050 -0.180
DBF4 0 -0.280 -0.140
POLA2 0 0.840 -0.250 -0.244
MCM10 0 -0.360 1.240 -0.938 0.303 -0.114
ORC1 0 1.400 -0.990
ORC1 0 1.400 -0.990 -0.583 -0.836
ORC6 0 0.840 -0.710
CDC45 0 -0.450 0.240 0.247 -0.108 0.308 -1.985
CDC6 0 -1.190 2.070
CDC7 0 -0.450 -0.150 -0.803
MCM5 0 -0.890 1.090
MCM5 0 -0.890 1.090 0.660 0.490 0.195
POLA1 0 0.720 -0.610 0.594 0.355 0.027
MCM4 0 0.700 0.170 0.876 0.344 -0.023 0.237 0.753
ORC2 0 -1.110 1.470 -0.064 0.370 -0.139 -0.210
ORC4 0 0.960 -0.540 -0.962 0.335
CDK2 0 -0.040 -0.300 -0.578 -0.797
CDK2 0 -0.040 -0.300 -0.202 -0.884 -0.107 -0.097 -0.501
MCM8 0 -0.350 0.360 0.876 0.344 -0.023 0.237 0.753
MCM8 0 -0.350 0.360
ORC3 0 0.100 -0.750 -0.143 0.299 0.290 0.037
ORC5 0 -0.900 1.340 -0.284 0.326 0.345 0.483 0.339
MCM7 0 -0.260 -0.010 0.361 -0.040
MCM7 0 -0.260 -0.010 0.592
POLE 0 -0.404 0.128 -0.376 -0.212
POLE 0 -0.273
PRIM1 0 -0.690 0.980

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
CDC45 Ubiquitylation K514 0.237 -1.244 _SFVCSTK(gl)NRR_
CDC45 Ubiquitylation K560 -0.065 -0.647 _AFEK(gl)AAESTSSR_
CDC6 Ubiquitylation K33 1.448 _NSSDAK(gl)LEPTNVQTVTCSPR_
CDC6 Phosphorylation S45 -0.996 _LEPTNVQTVTCS(ph)PR_
CDC6 Phosphorylation S54 -0.860 _ALPLS(ph)PR_
CDC6 Phosphorylation S106 -0.049 _LVFDNQLTIKS(ph)PSK_
CDC6 Ubiquitylation K221 1.075 _ILQDLKK(gl)_
CDC7 Ubiquitylation K253 -1.137 _ELDQQSTTK(gl)ASVK_
CDC7 Ubiquitylation K441 -1.134 _ETIQAAK(gl)TFGK_
CDK2 Ubiquitylation K6 -0.130 -0.399 _(ac)MENFQK(gl)VEK_
CDK2 Ubiquitylation K6 0.011 -0.784 _(ac)M(ox)EDYTK(gl)IEK_
CDK2 Phosphorylation T14 0.429 _IGEGT(ph)YGVVYK_
CDK2 Phosphorylation Y15 0.697 0.743 _IGEGTY(ph)GVVYK_
CDK2 Ubiquitylation K20 0.272 _IGEGTYGVVYK(gl)AR_
CDK2 Ubiquitylation K20 -0.327 -0.270 _IGEGTYGVVYK(gl)GR_
CDK2 Ubiquitylation K24 0.366 _NK(gl)LTGEVVALKK_
CDK2 Ubiquitylation K33 0.033 _NKLTGEVVALK(gl)K_
CDK2 Ubiquitylation K33 0.736 0.239 _TTGQVVAMK(gl)K_
CDK2 Ubiquitylation K34 0.542 _LTGEVVALKK(gl)_
CDK2 Ubiquitylation K34 -0.306 _TTGQVVAMKK(gl)_
CDK2 Ubiquitylation K58 0.312 -0.262 _EISLLK(gl)ELR_
CDK2 Ubiquitylation K136 -0.468 _DLK(gl)PQNLLIDDK(gl)GTIK_
CDK2 Ubiquitylation K145 0.161 -0.954 _DLKPQNLLIDDK(gl)GTIK_
CDK2 Ubiquitylation K149 -0.038 _GTIK(gl)LADFGLAR_
CDK2 Ubiquitylation K251 -0.047 -1.236 _WK(gl)PGSLASHVK_
CDK2 Ubiquitylation K280 0.179 -1.210 _MLIYDPAK(gl)R_
CDK2 Ubiquitylation K298 -1.907 -2.380 _QDFSK(gl)VVPPLDEDGR_
CDT1 Ubiquitylation K24 -3.025 1.688 _IAPPK(gl)LACR_
CDT1 Phosphorylation T29 -0.527 _T(ph)PSPARPALR_
CDT1 Phosphorylation S73 -1.743 _LRLS(ph)VDEVSSPSTPEAPDIPACPSPGQK_
CDT1 Phosphorylation S93 -2.789 _LSVDEVSSPSTPEAPDIPACPS(ph)PGQK_
CDT1 Ubiquitylation K218 0.676 _SETPTFAK(gl)VQR_
CDT1 Ubiquitylation K259 1.150 _SVPTFK(gl)DGTR_
CDT1 Phosphorylation S316 -0.503 _AFLAS(ph)LSPAMVVPEDQLTR_
CDT1 Phosphorylation S318 -2.552 -0.359 _AFLASLS(ph)PAMVVPEDQLTR_
CDT1 Ubiquitylation K377 3.560 _MEK(gl)ALSQLALR_
CDT1 Phosphorylation S411 -1.380 _PALPATPPATPPAAS(ph)PSALK_
CDT1 Ubiquitylation K522 0.136 _TDTYVK(gl)LDK_
DBF4 Phosphorylation S359 -0.054 -0.470 _YSVGSLS(ph)PVSASVLK_
MCM10 Phosphorylation T85 -0.290 _DEKENLATLFGDMEDLT(ph)DEEEVPASQSTENR_
MCM2 Phosphorylation S4 0.060 -0.102 _(ac)AES(ph)SESFTM(ox)ASS(ph)PAQR_
MCM2 Phosphorylation S5 0.653 0.313 _(ac)AESS(ph)ESFTMASSPAQR_
MCM2 Phosphorylation T9 0.528 0.894 _(ac)AESSESFT(ph)MASSPAQR_
MCM2 Phosphorylation S12 0.027 0.508 _AESSESFTMAS(ph)SPAQR_
MCM2 Phosphorylation S13 0.595 0.841 _(ac)AESSESFTMASS(ph)PAQR_
MCM2 Phosphorylation S26 0.334 0.204 _GNDPLTS(ph)SPGR_
MCM2 Phosphorylation S27 0.076 0.378 _GNDPLTSS(ph)PGR_
MCM2 Phosphorylation S40 0.648 1.028 _TDALTS(ph)SPGR_
MCM2 Phosphorylation S41 0.613 0.869 _RTDALTSS(ph)PGR_
MCM2 Phosphorylation T106 2.035 2.162 _AIPELDAYEAEGLALDDEDVEELT(ph)ASQR_
MCM2 Phosphorylation S108 1.832 2.212 _AIPELDAYEAEGLALDDEDVEELTAS(ph)QR_
MCM2 Phosphorylation S139 0.404 0.482 _GLLYDS(ph)DEEDEERPAR_
MCM2 Ubiquitylation K205 0.225 0.747 _ISDMCK(gl)ENR_
MCM2 Ubiquitylation K365 -0.341 0.407 _IQESPGK(gl)VAAGR_
MCM2 Ubiquitylation K450 0.216 0.470 _MITSLSK(gl)DQQIGEK_
MCM2 Ubiquitylation K946 -0.032 _FSHDLK(gl)R_
MCM3 Ubiquitylation K198 -0.209 -1.171 _SVHYCPATKK(gl)_
MCM3 Phosphorylation S205 0.571 -0.326 _RYS(ph)DLTTLVAFPSSSVYPTK_
MCM3 Phosphorylation T209 0.700 0.517 _RYSDLTT(ph)LVAFPSSSVYPTK_
MCM3 Ubiquitylation K293 0.760 -0.751 _K(gl)GGYTSGTFR_
MCM3 Ubiquitylation K311 0.886 1.210 _TVLIACNVK(gl)QMSK_
MCM3 Ubiquitylation K480 0.706 0.010 _VTIAK(gl)AGIHAR_
MCM3 Ubiquitylation K508 -0.031 _YDQYK(gl)TPMENIGLQDSLLSR_
MCM3 Phosphorylation S713 0.697 _S(ph)EDESETEDEEEKSQEDQEQK_
MCM3 Phosphorylation S717 0.009 0.302 _SEDES(ph)ETEDEEEK_
MCM3 Phosphorylation S756 -0.581 -0.455 _DGDSYDPYDFS(ph)DTEEEMPQVHTPK_
MCM3 Phosphorylation T758 -0.622 _DGDSYDPYDFS(ph)DTEEEM(ox)PQVHTPK_
MCM3 Phosphorylation T767 -0.699 -0.088 _DGDSYDPYDFSDTEEEMPQVHT(ph)PK_
MCM3 Ubiquitylation K777 -0.521 _TADSQETK(gl)ESQKVELSESR_
MCM3 Ubiquitylation K781 -0.081 -0.408 _ESQK(gl)VELSESR_
MCM4 Phosphorylation S26 -0.380 0.511 _ATPAQTPRS(ph)EDAR_
MCM4 Phosphorylation S131 0.424 0.474 _GLQVDLQS(ph)DGAAAEDIVASEQSLGQK_
MCM4 Ubiquitylation K220 -0.271 0.326 _SFDK(gl)NLYR_
MCM4 Phosphorylation S326 0.118 0.226 _IAEPS(ph)VCGR_
MCM4 Ubiquitylation K353 -0.534 _SLFSDKQMIK(gl)_
MCM4 Ubiquitylation K409 0.140 -0.445 _VSNVK(gl)SVYK_
MCM4 Ubiquitylation K450 -0.607 _VELLK(gl)ELSR_
MCM4 Ubiquitylation K478 -0.439 _LASALAPSIYEHEDIKK(gl)_
MCM4 Ubiquitylation K536 -0.941 -0.853 _GQYTSGK(gl)GSSAVGLTAYVMKDPETR_
MCM4 Ubiquitylation K549 -0.023 -0.647 _GSSAVGLTAYVMK(gl)DPETR_
MCM4 Ubiquitylation K628 -1.124 -3.224 _TSVLAAANPIESQWNPKK(gl)_
MCM4 Ubiquitylation K746 -0.079 _LAEAHAK(gl)VR_
MCM4 Ubiquitylation K752 -0.885 -0.700 _LSNK(gl)VEAIDVEEAK(gl)R_
MCM4 Ubiquitylation K762 -0.483 -0.551 _VEAIDVEEAK(gl)R_
MCM4 Ubiquitylation K770 -0.963 -0.688 _EALK(gl)QSATDPR_
MCM4 Ubiquitylation K814 -1.087 _GK(gl)TPALK_
MCM4 Ubiquitylation K858 0.042 _ALADDDFLTVTGK(gl)TVR_
MCM5 Phosphorylation S2 0.212 0.649 _S(ph)GFDDPGIFYSDSFGGDAQADEGQAR_
MCM5 Phosphorylation S14 1.191 _(ac)SGFDDPGIFYSDS(ph)FGGDAQADEGQAR_
MCM5 Ubiquitylation K392 -0.464 -0.556 _SQLLK(gl)FVEK_
MCM5 Ubiquitylation K583 0.060 -0.670 _LSAEAAEKLK(gl)_
MCM6 Phosphorylation S13 4.283 4.775 _(ac)M(ox)DLAAAAEPGAGS(ph)QHLEVRDEVAEK_
MCM6 Ubiquitylation K95 0.656 _ALK(gl)TFVK_
MCM6 Ubiquitylation K197 0.461 0.797 _FLLDTNK(gl)SR_
MCM6 Ubiquitylation K332 0.272 0.709 _NQMTVK(gl)EWEK_
MCM6 Ubiquitylation K422 0.854 _AVYTSGK(gl)ASSAAGLTAAVVR_
MCM6 Ubiquitylation K490 0.630 _AGVK(gl)ATLNAR_
MCM6 Ubiquitylation K517 0.150 -0.502 _SLK(gl)QNINLSAPIMSR_
MCM6 Ubiquitylation K611 1.032 0.016 _DGSGVTK(gl)SSWR_
MCM6 Ubiquitylation K643 -0.198 _MHCCDEVQPK(gl)HVK_
MCM6 Ubiquitylation K654 0.288 -0.028 _LLNK(gl)SIIR_
MCM6 Ubiquitylation K744 -0.152 -0.415 _KVEEEEDESALK(gl)R_
MCM6 Phosphorylation S758 0.528 2.700 _EIES(ph)EIDSEEELINK_
MCM6 Phosphorylation S762 1.561 1.325 _EIESEIDS(ph)EEELINK_
MCM6 Ubiquitylation K775 0.748 _IIEK(gl)VIHR_
MCM7 Ubiquitylation K4 -1.164 _(ac)ALK(gl)DYALEKEK_
MCM7 Ubiquitylation K10 -0.334 -1.453 _(ac)ALKDYALEK(gl)EK_
MCM7 Ubiquitylation K12 -1.492 _DYALEK(gl)EK_
MCM7 Ubiquitylation K28 -0.102 -0.861 _FLQEFYQDDELGK(gl)K_
MCM7 Ubiquitylation K29 -1.023 -0.094 _FLQEFYQDDELGKK(gl)QFK_
MCM7 Ubiquitylation K32 0.146 -0.970 _QFK(gl)YGNQLVR_
MCM7 Ubiquitylation K89 -1.906 -1.328 _LFADAVQELLPQYK(gl)ER_
MCM7 Phosphorylation S121 0.902 0.509 _S(ph)PQNQYPAELMR_
MCM7 Ubiquitylation K145 -2.703 _RFELYFQGPSSNK(gl)PR_
MCM7 Ubiquitylation K159 0.038 -0.495 _ADSVGK(gl)LVTVR_
MCM7 Ubiquitylation K231 -0.965 _FIK(gl)FQEMK_
MCM7 Ubiquitylation K236 -1.769 _FQEMK(gl)MQEHSDQVPVGNIPR_
MCM7 Ubiquitylation K352 -1.468 _LAASIAPEIYGHEDVKK(gl)_
MCM7 Ubiquitylation K557 -2.556 -2.098 _QPPSQFEPLDMK(gl)LMR_
MCM7 Ubiquitylation K596 -0.751 -0.539 _REAWASK(gl)DATYTSAR_
MCM7 Ubiquitylation K627 -0.965 -0.588 _MVDVVEK(gl)EDVNEAIR_
MCM7 Ubiquitylation K641 -0.836 -0.945 _LMEMSK(gl)DSLLGDKGQTAR_
MCM7 Ubiquitylation K648 -0.422 -0.441 _DSLLGDK(gl)GQTAR_
MCM8 Phosphorylation S26 -0.380 0.511 _ATPAQTPRS(ph)EDAR_
MCM8 Phosphorylation S131 0.424 0.474 _GLQVDLQS(ph)DGAAAEDIVASEQSLGQK_
MCM8 Ubiquitylation K208 1.456 _VYNYEPLTQLK(gl)NVR_
MCM8 Ubiquitylation K220 -0.271 0.326 _SFDK(gl)NLYR_
MCM8 Ubiquitylation K263 -0.018 _YSLPTK(gl)CPVPVCR_
MCM8 Phosphorylation S326 0.118 0.226 _IAEPS(ph)VCGR_
MCM8 Ubiquitylation K353 -0.534 _SLFSDKQMIK(gl)_
MCM8 Ubiquitylation K409 0.140 -0.445 _VSNVK(gl)SVYK_
MCM8 Ubiquitylation K450 -0.607 _VELLK(gl)ELSR_
MCM8 Ubiquitylation K478 -0.439 _LASALAPSIYEHEDIKK(gl)_
MCM8 Ubiquitylation K536 -0.941 -0.853 _GQYTSGK(gl)GSSAVGLTAYVMKDPETR_
MCM8 Ubiquitylation K549 -0.023 -0.647 _GSSAVGLTAYVMK(gl)DPETR_
MCM8 Ubiquitylation K611 -1.605 _TSIIAAANPVGGHYNKAK(gl)_
MCM8 Ubiquitylation K628 -1.124 -3.224 _TSVLAAANPIESQWNPKK(gl)_
MCM8 Ubiquitylation K746 -0.079 _LAEAHAK(gl)VR_
MCM8 Ubiquitylation K752 -0.885 -0.700 _LSNK(gl)VEAIDVEEAK(gl)R_
MCM8 Ubiquitylation K762 -0.483 -0.551 _VEAIDVEEAK(gl)R_
MCM8 Ubiquitylation K770 -0.963 -0.688 _EALK(gl)QSATDPR_
MCM8 Ubiquitylation K814 -1.087 _GK(gl)TPALK_
MCM8 Ubiquitylation K858 0.042 _ALADDDFLTVTGK(gl)TVR_
ORC1 Ubiquitylation K99 -0.379 _FCEVPACK(gl)R_
ORC1 Ubiquitylation K149 0.303 -0.651 _DVVPTNLK(gl)NEK_
ORC1 Ubiquitylation K152 -0.651 _DVVPTNLK(gl)NEK_
ORC2 Phosphorylation T116 -0.144 -1.304 _LASELAKT(ph)PQK_
ORC2 Phosphorylation T226 -0.976 -1.179 _VVSAPVGKET(ph)PSK_
ORC2 Phosphorylation S228 -0.380 -0.851 _VVSAPVGKETPS(ph)KR_
ORC3 Ubiquitylation K96 0.483 _DLGGQIK(gl)LR_
ORC3 Ubiquitylation K383 -1.713 _QASEK(gl)QVALLTNER_
ORC3 Ubiquitylation K492 0.542 _SYCENHLGSTAK(gl)R_
ORC3 Ubiquitylation K537 1.080 _SLLEMK(gl)ELR_
ORC3 Ubiquitylation K547 -0.396 _QTK(gl)FEVLR_
ORC5 Ubiquitylation K242 -1.334 _YCEPVVK(gl)GEASER_
ORC5 Ubiquitylation K263 -0.323 _NIEPHLKK(gl)_
ORC6 Ubiquitylation K169 0.158 _MVATSGVKK(gl)_
ORC6 Phosphorylation T195 -1.091 -0.575 _IGQQVDREPGDVAT(ph)PPRK_
POLA1 Phosphorylation S192 -0.049 -0.187 _S(ph)IGASPNPFSVHTATAVPSGK_
POLA1 Phosphorylation S196 -0.374 _RSIGAS(ph)PNPFSVHTATAVPSGK_
POLA1 Ubiquitylation K1120 -0.317 _DTIVENIQK(gl)R_
POLA2 Phosphorylation T127 -0.548 0.195 _AIST(ph)PET(ph)PLTK_
POLA2 Phosphorylation T130 -1.549 _AIST(ph)PET(ph)PLTK_
POLA2 Ubiquitylation K134 -1.351 _AISTPETPLTK(gl)R_
POLA2 Phosphorylation S141 -0.772 -0.619 _S(ph)PHQLLSPSSFSPSATPSQK_
POLA2 Ubiquitylation K160 -1.904 _SPHQLLSPSSFSPSATPSQK(gl)YNSR_
POLA2 Ubiquitylation K212 -0.097 _SMFQK(gl)LPDIR_
POLA2 Ubiquitylation K500 -0.292 -0.131 _ILK(gl)HILTQR_
POLA2 Ubiquitylation K564 -0.298 -0.082 _LTK(gl)GQVGGTFAR_
POLE Ubiquitylation K187 -0.801 _EISPAVKK(gl)_
POLE Ubiquitylation K436 -0.163 _DSYLPVGSHNLK(gl)AAAK_
POLE Ubiquitylation K1061 -1.582 _KLEDYGEQK(gl)STSISTAK_
POLE Ubiquitylation K1081 -1.440 _LAEFLGDQMVK(gl)DAGLSCR_
POLE Ubiquitylation K1385 -1.054 -0.957 _VAK(gl)AEEGASYR_
POLE Ubiquitylation K1573 -0.910 _AETDLK(gl)TICR_
POLE Ubiquitylation K1587 -0.722 _FLLAYK(gl)EER_
POLE Ubiquitylation K2121 0.432 _YVCK(gl)VLSLDTNITNQVNK_
POLE Ubiquitylation K2135 -0.740 -1.214 _VLSLDTNITNQVNK(gl)LNR_
POLE2 Ubiquitylation K15 0.263 -0.418 _ALSAFK(gl)LR_
POLE2 Ubiquitylation K339 -0.257 _NQVQALK(gl)DSLK_
POLE2 Ubiquitylation K523 -1.031 _TVEDSK(gl)LQGF_
PRIM1 Ubiquitylation K147 1.418 _ALK(gl)EDFGFK_
PRIM1 Ubiquitylation K326 -0.141 -1.351 _SPFSVHPK(gl)TGR_
PRIM1 Ubiquitylation K377 -0.093 _ELDAISTNEEEKEENEAESDVK(gl)HR_
RPA1 Ubiquitylation K163 2.827 4.085 _AYGASK(gl)TFGK_
RPA1 Ubiquitylation K167 3.009 3.243 _TFGK(gl)AAGPSLSHTSGGTQSK_
RPA1 Ubiquitylation K183 0.925 _AAGPSLSHTSGGTQSK(gl)VVPIASLTPYQSK_
RPA1 Ubiquitylation K263 -1.803 _GTLK(gl)IANK_
RPA1 Ubiquitylation K267 2.751 _IANK(gl)QFTAVK_
RPA1 Ubiquitylation K331 3.112 4.066 _SYEDATK(gl)ITVR_
RPA1 Ubiquitylation K410 2.458 _SLSVLSSSTIIANPDIPEAYK(gl)LR_
RPA1 Ubiquitylation K489 0.465 2.335 _K(gl)VIDQQNGLYR_
RPA1 Ubiquitylation K588 -0.055 _IK(gl)ATVMDVKPVDYR_
RPA1 Ubiquitylation K595 1.201 _ATVMDVK(gl)PVDYR_
RPA2 Ubiquitylation K85 0.693 _HAEK(gl)APTNIVYK_
RPA2 Ubiquitylation K235 1.339 _NQLK(gl)HMSVSSIK_
RPA3 Ubiquitylation K33 0.794 _LEK(gl)IHPTGK_
RPA3 Ubiquitylation K39 1.508 1.875 _IHPTGK(gl)MFILSDGEGK_


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