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Query: ORC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ORC1 0 -1.495 1.400 -0.990
ORC1 0 -1.495 1.400 -0.990 -0.583 -0.836

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ORC1 Ubiquitylation K99 -0.379 _FCEVPACK(gl)R_
ORC1 Ubiquitylation K149 0.303 -0.651 _DVVPTNLK(gl)NEK_
ORC1 Ubiquitylation K152 -0.651 _DVVPTNLK(gl)NEK_

Background Information for ORC1:


Pubmed-ORC1 »
Uniprot-ORC1 »
Biogrid-ORC1 »
ProteomicsDB-ORC1 »

Tumorportal-ORC1 »
COSMIC-ORC1 »
GenomeRNAi-ORC1 »
Genecards-ORC1


Protein-protein Interactions for ORC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATRX Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRWD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ORC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members BAH_dom IPR001025 0.62
Category members DUF2075 IPR018647 0.41
Category members AAA+_ATPase IPR003593 0.38
Category members ATPase_AAA_core IPR003959 0.14
Category members Cdc6_C_dom IPR015163 0


Protein complexes (CORUM database) featuring ORC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1031 ORC complex (origin recognition complex) Database 0.22
Category members Corum 1033 ORC complex (origin recognition complex) Database 0.22
Category members Corum 389 ORC complex (origin recognition complex) Database 0.22
Category members Corum 2210 BRCA1-IRIS-pre-replication complex Database 0.08
Category members Corum 1038 ORC 1-5 complex (origin recognition 1-5 complex) Database 0.04
Category members Corum 2205 ORC5-ORC1 complex Database 0


Categories featuring ORC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_828 REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 0 0.82
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0006270 DNA replication initiation Database 0.57
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members Disease phenotype Ear-patella-short_stature_syndrome Ear-patella-short stature syndrome Database 0.4
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members Pathway Pathway_1251 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION 0 0.35
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0000808 origin recognition complex Database 0.22
Category members Pathway Pathway_778 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX 0 0.1
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1
Category members Pathway Pathway_1253 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX 0 0.04
Category members GO Category GO:0005664 nuclear origin of replication recognition complex Database 0


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