Results for the Category
REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION
(Pathway_1251)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| ORC1 | 0 | 1.400 | -0.990 | |||||
| ORC1 | 0 | 1.400 | -0.990 | -0.583 | -0.836 | |||
| ORC6 | 0 | 0.840 | -0.710 | |||||
| ORC2 | 0 | -1.110 | 1.470 | -0.064 | 0.370 | -0.139 | -0.210 | |
| ORC4 | 0 | 0.960 | -0.540 | -0.962 | 0.335 | |||
| MCM8 | 0 | -0.350 | 0.360 | 0.876 | 0.344 | -0.023 | 0.237 | 0.753 |
| MCM8 | 0 | -0.350 | 0.360 | |||||
| CCNB1 | 0 | -0.410 | -0.128 | 0.212 | -0.166 | -0.523 | ||
| ORC3 | 0 | 0.100 | -0.750 | -0.143 | 0.299 | 0.290 | 0.037 | |
| CDC25A | 0 | 0.260 | -0.100 | |||||
| ORC5 | 0 | -0.900 | 1.340 | -0.284 | 0.326 | 0.345 | 0.483 | 0.339 |
| CDK1 | 0 | -0.370 | 0.080 | -0.202 | -0.884 | -0.107 | -0.097 | -0.501 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| CCNB1 | Ubiquitylation | K18 | -0.455 | _AK(gl)INMAGAK_ | |
| CCNB1 | Ubiquitylation | K36 | -1.833 | -2.301 | _VPTAPAATSK(gl)PGLRPR_ |
| CCNB1 | Ubiquitylation | K59 | -0.659 | _VSEQLQAK(gl)MPMK_ | |
| CCNB1 | Ubiquitylation | K288 | 0.578 | _QMEMK(gl)ILR_ | |
| CDC25A | Ubiquitylation | K120 | 1.111 | _LLGCSPALK(gl)R_ | |
| CDK1 | Ubiquitylation | K6 | 0.011 | -0.784 | _(ac)M(ox)EDYTK(gl)IEK_ |
| CDK1 | Ubiquitylation | K20 | -0.327 | -0.270 | _IGEGTYGVVYK(gl)GR_ |
| CDK1 | Ubiquitylation | K33 | 0.736 | 0.239 | _TTGQVVAMK(gl)K_ |
| CDK1 | Ubiquitylation | K34 | -0.306 | _TTGQVVAMKK(gl)_ | |
| CDK1 | Ubiquitylation | K58 | 0.312 | -0.262 | _EISLLK(gl)ELR_ |
| CDK1 | Ubiquitylation | K136 | -0.468 | _DLK(gl)PQNLLIDDK(gl)GTIK_ | |
| CDK1 | Ubiquitylation | K145 | 0.161 | -0.954 | _DLKPQNLLIDDK(gl)GTIK_ |
| CDK1 | Ubiquitylation | K149 | -0.038 | _GTIK(gl)LADFGLAR_ | |
| CDK1 | Ubiquitylation | K251 | -0.047 | -1.236 | _WK(gl)PGSLASHVK_ |
| CDK1 | Ubiquitylation | K280 | 0.179 | -1.210 | _MLIYDPAK(gl)R_ |
| MCM8 | Phosphorylation | S26 | -0.380 | 0.511 | _ATPAQTPRS(ph)EDAR_ |
| MCM8 | Phosphorylation | S131 | 0.424 | 0.474 | _GLQVDLQS(ph)DGAAAEDIVASEQSLGQK_ |
| MCM8 | Ubiquitylation | K208 | 1.456 | _VYNYEPLTQLK(gl)NVR_ | |
| MCM8 | Ubiquitylation | K220 | -0.271 | 0.326 | _SFDK(gl)NLYR_ |
| MCM8 | Ubiquitylation | K263 | -0.018 | _YSLPTK(gl)CPVPVCR_ | |
| MCM8 | Phosphorylation | S326 | 0.118 | 0.226 | _IAEPS(ph)VCGR_ |
| MCM8 | Ubiquitylation | K353 | -0.534 | _SLFSDKQMIK(gl)_ | |
| MCM8 | Ubiquitylation | K409 | 0.140 | -0.445 | _VSNVK(gl)SVYK_ |
| MCM8 | Ubiquitylation | K450 | -0.607 | _VELLK(gl)ELSR_ | |
| MCM8 | Ubiquitylation | K478 | -0.439 | _LASALAPSIYEHEDIKK(gl)_ | |
| MCM8 | Ubiquitylation | K536 | -0.941 | -0.853 | _GQYTSGK(gl)GSSAVGLTAYVMKDPETR_ |
| MCM8 | Ubiquitylation | K549 | -0.023 | -0.647 | _GSSAVGLTAYVMK(gl)DPETR_ |
| MCM8 | Ubiquitylation | K611 | -1.605 | _TSIIAAANPVGGHYNKAK(gl)_ | |
| MCM8 | Ubiquitylation | K628 | -1.124 | -3.224 | _TSVLAAANPIESQWNPKK(gl)_ |
| MCM8 | Ubiquitylation | K746 | -0.079 | _LAEAHAK(gl)VR_ | |
| MCM8 | Ubiquitylation | K752 | -0.885 | -0.700 | _LSNK(gl)VEAIDVEEAK(gl)R_ |
| MCM8 | Ubiquitylation | K762 | -0.483 | -0.551 | _VEAIDVEEAK(gl)R_ |
| MCM8 | Ubiquitylation | K770 | -0.963 | -0.688 | _EALK(gl)QSATDPR_ |
| MCM8 | Ubiquitylation | K814 | -1.087 | _GK(gl)TPALK_ | |
| MCM8 | Ubiquitylation | K858 | 0.042 | _ALADDDFLTVTGK(gl)TVR_ | |
| ORC1 | Ubiquitylation | K99 | -0.379 | _FCEVPACK(gl)R_ | |
| ORC1 | Ubiquitylation | K149 | 0.303 | -0.651 | _DVVPTNLK(gl)NEK_ |
| ORC1 | Ubiquitylation | K152 | -0.651 | _DVVPTNLK(gl)NEK_ | |
| ORC2 | Phosphorylation | T116 | -0.144 | -1.304 | _LASELAKT(ph)PQK_ |
| ORC2 | Phosphorylation | T226 | -0.976 | -1.179 | _VVSAPVGKET(ph)PSK_ |
| ORC2 | Phosphorylation | S228 | -0.380 | -0.851 | _VVSAPVGKETPS(ph)KR_ |
| ORC3 | Ubiquitylation | K96 | 0.483 | _DLGGQIK(gl)LR_ | |
| ORC3 | Ubiquitylation | K383 | -1.713 | _QASEK(gl)QVALLTNER_ | |
| ORC3 | Ubiquitylation | K492 | 0.542 | _SYCENHLGSTAK(gl)R_ | |
| ORC3 | Ubiquitylation | K537 | 1.080 | _SLLEMK(gl)ELR_ | |
| ORC3 | Ubiquitylation | K547 | -0.396 | _QTK(gl)FEVLR_ | |
| ORC5 | Ubiquitylation | K242 | -1.334 | _YCEPVVK(gl)GEASER_ | |
| ORC5 | Ubiquitylation | K263 | -0.323 | _NIEPHLKK(gl)_ | |
| ORC6 | Ubiquitylation | K169 | 0.158 | _MVATSGVKK(gl)_ | |
| ORC6 | Phosphorylation | T195 | -1.091 | -0.575 | _IGQQVDREPGDVAT(ph)PPRK_ |
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