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Query: CDC25A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDC25A 0 1.111 0.260 -0.100

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDC25A Ubiquitylation K120 1.111 _LLGCSPALK(gl)R_

Background Information for CDC25A:


Pubmed-CDC25A »
Uniprot-CDC25A »
Biogrid-CDC25A »
ProteomicsDB-CDC25A »

Tumorportal-CDC25A »
COSMIC-CDC25A »
GenomeRNAi-CDC25A »
Genecards-CDC25A


Protein-protein Interactions for CDC25A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC25A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDC25A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members MPI_Phosphatase IPR000751 0
Category members Rhodanese-like_dom IPR001763 0


Protein complexes (CORUM database) featuring CDC25A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CDC25A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_798 REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 0 1.64
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members GO Category GO:0034644 cellular response to UV Database 0.49
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members Pathway Pathway_1251 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION 0 0.35
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members GO Category GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity Database 0.13
Category members Pathway Pathway_1029 BIOCARTA_SRCRPTP_PATHWAY 0 0.08
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_971 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION 0 0.06
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members Pathway Pathway_969 BIOCARTA_PTC1_PATHWAY 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members Pathway Pathway_972 SA_G2_AND_M_PHASES 0 0
Category members GO Category GO:0000087 mitotic M phase Database 0
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0


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