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Query: MCM8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCM8 0 5.078 -0.350 0.360
MCM8 0 5.078 -0.350 0.360 0.876 0.344 -0.023 0.237 0.753

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCM8 Ubiquitylation K208 1.456 _VYNYEPLTQLK(gl)NVR_
MCM8 Phosphorylation S26 -0.380 0.511 _ATPAQTPRS(ph)EDAR_
MCM8 Phosphorylation S131 0.424 0.474 _GLQVDLQS(ph)DGAAAEDIVASEQSLGQK_
MCM8 Ubiquitylation K220 -0.271 0.326 _SFDK(gl)NLYR_
MCM8 Phosphorylation S326 0.118 0.226 _IAEPS(ph)VCGR_
MCM8 Ubiquitylation K263 -0.018 _YSLPTK(gl)CPVPVCR_
MCM8 Ubiquitylation K746 -0.079 _LAEAHAK(gl)VR_
MCM8 Ubiquitylation K478 -0.439 _LASALAPSIYEHEDIKK(gl)_
MCM8 Ubiquitylation K409 0.140 -0.445 _VSNVK(gl)SVYK_
MCM8 Ubiquitylation K353 -0.534 _SLFSDKQMIK(gl)_
MCM8 Ubiquitylation K762 -0.483 -0.551 _VEAIDVEEAK(gl)R_
MCM8 Ubiquitylation K450 -0.607 _VELLK(gl)ELSR_
MCM8 Ubiquitylation K549 -0.023 -0.647 _GSSAVGLTAYVMK(gl)DPETR_
MCM8 Ubiquitylation K770 -0.963 -0.688 _EALK(gl)QSATDPR_
MCM8 Ubiquitylation K752 -0.885 -0.700 _LSNK(gl)VEAIDVEEAK(gl)R_
MCM8 Ubiquitylation K536 -0.941 -0.853 _GQYTSGK(gl)GSSAVGLTAYVMKDPETR_
MCM8 Ubiquitylation K814 -1.087 _GK(gl)TPALK_
MCM8 Ubiquitylation K611 -1.605 _TSIIAAANPVGGHYNKAK(gl)_
MCM8 Ubiquitylation K628 -1.124 -3.224 _TSVLAAANPIESQWNPKK(gl)_
MCM8 Ubiquitylation K858 0.042 _ALADDDFLTVTGK(gl)TVR_

Background Information for MCM8:


Pubmed-MCM8 »
Uniprot-MCM8 »
Biogrid-MCM8 »
ProteomicsDB-MCM8 »

Tumorportal-MCM8 »
COSMIC-MCM8 »
GenomeRNAi-MCM8 »
Genecards-MCM8


Protein-protein Interactions for MCM8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AVIL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BPNT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait F9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM167A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL17RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IQCF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLK5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MCM9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSG8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPYL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUBB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VWA5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCM8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members Mg_chelatse_chII IPR000523 0.94
Category members MCM_DNA-dep_ATPase IPR001208 0.93
Category members AAA+_ATPase IPR003593 0.38


Protein complexes (CORUM database) featuring MCM8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2204 MCM8-ORC2-CDC6 complex Database 0


Categories featuring MCM8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0000724 double-strand break repair via homologous recombination Database 2.41
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0015979 photosynthesis Database 1.35
Category members GO Category GO:0015995 chlorophyll biosynthetic process Database 1.35
Category members GO Category GO:0016851 magnesium chelatase activity Database 1.35
Category members GO Category GO:0006271 DNA strand elongation involved in DNA replication Database 1.33
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_327 REACTOME_DNA_STRAND_ELONGATION 0 0.9
Category members Pathway Pathway_828 REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 0 0.82
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_868 REACTOME_UNWINDING_OF_DNA 0 0.44
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members Pathway Pathway_1251 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION 0 0.35
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0007292 female gamete generation Database 0.16
Category members Pathway Pathway_1253 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX 0 0.04


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