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Query: ORC3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ORC3 0 1.563 0.100 -0.750 -0.143 0.299 0.290 0.037

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ORC3 Ubiquitylation K537 1.080 _SLLEMK(gl)ELR_
ORC3 Ubiquitylation K492 0.542 _SYCENHLGSTAK(gl)R_
ORC3 Ubiquitylation K96 0.483 _DLGGQIK(gl)LR_
ORC3 Ubiquitylation K547 -0.396 _QTK(gl)FEVLR_
ORC3 Ubiquitylation K383 -1.713 _QASEK(gl)QVALLTNER_

Background Information for ORC3:


Pubmed-ORC3 »
Uniprot-ORC3 »
Biogrid-ORC3 »
ProteomicsDB-ORC3 »

Tumorportal-ORC3 »
COSMIC-ORC3 »
GenomeRNAi-ORC3 »
Genecards-ORC3


Protein-protein Interactions for ORC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FIGN Cat. description Hein, Mann, Cell 2015
Category members IP bait KIFAP3 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRWD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NOP9 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait QSOX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TACC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOR1AIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VAPA Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR48 Cat. description Hein, Mann, Cell 2015
Category members IP bait OBFC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPGR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ORC3
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring ORC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1031 ORC complex (origin recognition complex) Database 0.22
Category members Corum 1033 ORC complex (origin recognition complex) Database 0.22
Category members Corum 389 ORC complex (origin recognition complex) Database 0.22
Category members Corum 1038 ORC 1-5 complex (origin recognition 1-5 complex) Database 0.04
Category members Corum 1032 ORC 2-4 complex (origin recognition 2-4 complex) Database 0
Category members Corum 1034 ORC 2-5 complex (origin recognition 2-5 complex) Database 0
Category members Corum 5251 Ku-ORC complex Database 0


Categories featuring ORC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_864 REACTOME_ACTIVATION_OF_ATR_IN_RESPONSE_TO_REPLICATION_STRESS 0 1.21
Category members Pathway Pathway_828 REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 0 0.82
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members Pathway Pathway_1251 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION 0 0.35
Category members Pathway Pathway_318 REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX 0 0.25
Category members GO Category GO:0000808 origin recognition complex Database 0.22
Category members Pathway Pathway_778 REACTOME_ASSOCIATION_OF_LICENSING_FACTORS_WITH_THE_PRE_REPLICATIVE_COMPLEX 0 0.1
Category members Pathway Pathway_867 BIOCARTA_MCM_PATHWAY 0 0.1
Category members Pathway Pathway_1253 REACTOME_CDC6_ASSOCIATION_WITH_THE_ORC_ORIGIN_COMPLEX 0 0.04
Category members GO Category GO:0003688 DNA replication origin binding Database 0
Category members GO Category GO:0005664 nuclear origin of replication recognition complex Database 0
Category members GO Category GO:0061351 neural precursor cell proliferation Database 0


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