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Query: CDK1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDK1 0 -0.736 -0.370 0.080 -0.202 -0.884 -0.107 -0.097 -0.501

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDK1 Ubiquitylation K33 0.736 0.239 _TTGQVVAMK(gl)K_
CDK1 Ubiquitylation K149 -0.038 _GTIK(gl)LADFGLAR_
CDK1 Ubiquitylation K58 0.312 -0.262 _EISLLK(gl)ELR_
CDK1 Ubiquitylation K20 -0.327 -0.270 _IGEGTYGVVYK(gl)GR_
CDK1 Ubiquitylation K34 -0.306 _TTGQVVAMKK(gl)_
CDK1 Ubiquitylation K136 -0.468 _DLK(gl)PQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K6 0.011 -0.784 _(ac)M(ox)EDYTK(gl)IEK_
CDK1 Ubiquitylation K145 0.161 -0.954 _DLKPQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K280 0.179 -1.210 _MLIYDPAK(gl)R_
CDK1 Ubiquitylation K251 -0.047 -1.236 _WK(gl)PGSLASHVK_

Background Information for CDK1:


Pubmed-CDK1 »
Uniprot-CDK1 »
Biogrid-CDK1 »
ProteomicsDB-CDK1 »

Tumorportal-CDK1 »
COSMIC-CDK1 »
GenomeRNAi-CDK1 »
Genecards-CDK1


Protein-protein Interactions for CDK1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCNB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCND1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC102B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCNA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDC20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS1B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CKS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDK1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CDK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1005 RC complex during G2/M-phase of cell cycle Database 0.67
Category members Corum 310 Cell cycle kinase complex CDC2 Database 0.52
Category members Corum 5551 CDC2-CCNB1-PTCH1 complex Database 0.44
Category members Corum 5542 CCNB2-CDC2 complex Database 0.31
Category members Corum 5543 CCNB1-CDC2 complex Database 0.31
Category members Corum 5643 ESPL1-CDC2 complex Database 0.31
Category members Corum 5557 CDC2-CCNA2 complex Database 0.18
Category members Corum 5546 CDC2-PCNA-CCNB1-GADD45G complex Database 0.1
Category members Corum 243 RalBP1-CDC2-CCNB1 complex Database 0.08
Category members Corum 5550 CDC2-CCNB1-CCNF complex Database 0.08
Category members Corum 5544 CDC2-PCNA-CCNB1-GADD45A complex Database 0
Category members Corum 5545 CDC2-PCNA-CCNB1-GADD45B complex Database 0
Category members Corum 5559 CDC2-CCNA2-CDK2 complex Database 0


Categories featuring CDK1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_784 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 0 2.26
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members Pathway Pathway_818 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_CYCLIN_B 0 1.37
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_1245 REACTOME_PHOSPHORYLATION_OF_THE_APC_C 0 1.06
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members Pathway Pathway_863 REACTOME_G2_M_CHECKPOINTS 0 0.74
Category members Pathway Pathway_229 REACTOME_SIGNALING_BY_ERBB2 0 0.68
Category members GO Category GO:0005876 spindle microtubule Database 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0006461 protein complex assembly Database 0.57
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members Pathway Pathway_599 REACTOME_SIGNALING_BY_SCF_KIT 0 0.48
Category members Pathway Pathway_688 REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 0 0.47
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_255 REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 0 0.42
Category members GO Category GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity Database 0.42
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members Pathway Pathway_1004 REACTOME_ARMS_MEDIATED_ACTIVATION 0 0.4
Category members Pathway Pathway_247 REACTOME_SIGNALING_BY_PDGF 0 0.4
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members Pathway Pathway_1251 REACTOME_E2F_ENABLED_INHIBITION_OF_PRE_REPLICATION_COMPLEX_FORMATION 0 0.35
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members Pathway Pathway_214 REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0035666 TRIF-dependent toll-like receptor signaling pathway Database 0.29
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0034138 toll-like receptor 3 signaling pathway Database 0.28
Category members GO Category GO:0034142 toll-like receptor 4 signaling pathway Database 0.27
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0002756 MyD88-independent toll-like receptor signaling pathway Database 0.25
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members Pathway Pathway_1248 REACTOME_G2_M_DNA_DAMAGE_CHECKPOINT 0 0.21
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0000186 activation of MAPKK activity Database 0.16
Category members Pathway Pathway_694 REACTOME_SIGNALLING_TO_ERKS 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0014075 response to amine Database 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members GO Category GO:0030544 Hsp70 protein binding Database 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0016572 histone phosphorylation Database 0.09
Category members GO Category GO:0060045 positive regulation of cardiac muscle cell proliferation Database 0.09
Category members Pathway Pathway_1029 BIOCARTA_SRCRPTP_PATHWAY 0 0.08
Category members GO Category GO:0004693 cyclin-dependent protein serine/threonine kinase activity Database 0.08
Category members Pathway Pathway_971 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION 0 0.06
Category members Pathway Pathway_236 BIOCARTA_MPR_PATHWAY 0 0.06
Category members Pathway Pathway_1138 BIOCARTA_STATHMIN_PATHWAY 0 0.06
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0033160 positive regulation of protein import into nucleus, translocation Database 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0034146 toll-like receptor 5 signaling pathway Database 0.04
Category members GO Category GO:0034166 toll-like receptor 10 signaling pathway Database 0.04
Category members Pathway Pathway_1115 REACTOME_SOS_MEDIATED_SIGNALLING 0 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members Pathway Pathway_1118 REACTOME_RAF_MAP_KINASE_CASCADE 0 0.03
Category members GO Category GO:0007569 cell aging Database 0.03
Category members GO Category GO:0010243 response to organonitrogen compound Database 0.02
Category members GO Category GO:0034134 toll-like receptor 2 signaling pathway Database 0.01
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0048678 response to axon injury Database 0.01
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members Pathway Pathway_1002 REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 0 0
Category members Pathway Pathway_1010 REACTOME_NCAM_SIGNALING_FOR_NEURITE_OUT_GROWTH 0 0
Category members Pathway Pathway_1030 BIOCARTA_RB_PATHWAY 0 0
Category members Pathway Pathway_1066 REACTOME_SHC1_EVENTS_IN_EGFR_SIGNALING 0 0
Category members Pathway Pathway_1070 REACTOME_GRB2_EVENTS_IN_ERBB2_SIGNALING 0 0
Category members Pathway Pathway_1091 REACTOME_FRS2_MEDIATED_CASCADE 0 0
Category members Pathway Pathway_1108 REACTOME_SHC_RELATED_EVENTS 0 0
Category members Pathway Pathway_1111 REACTOME_SHC_MEDIATED_SIGNALLING 0 0
Category members Pathway Pathway_1112 REACTOME_SHC1_EVENTS_IN_ERBB4_SIGNALING 0 0
Category members Pathway Pathway_1114 REACTOME_SIGNALLING_TO_RAS 0 0
Category members Pathway Pathway_1153 BIOCARTA_AKAPCENTROSOME_PATHWAY 0 0
Category members Pathway Pathway_1252 REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_504 REACTOME_SIGNALING_BY_ILS 0 0
Category members Pathway Pathway_512 REACTOME_IL_2_SIGNALING 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_869 REACTOME_G0_AND_EARLY_G1 0 0
Category members Pathway Pathway_879 BIOCARTA_AKAP95_PATHWAY 0 0
Category members Pathway Pathway_946 PID_RETINOIC_ACID_PATHWAY 0 0
Category members Pathway Pathway_969 BIOCARTA_PTC1_PATHWAY 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members Pathway Pathway_972 SA_G2_AND_M_PHASES 0 0
Category members GO Category GO:0000165 MAPK cascade Database 0
Category members GO Category GO:0000187 activation of MAPK activity Database 0
Category members GO Category GO:0002755 MyD88-dependent toll-like receptor signaling pathway Database 0
Category members GO Category GO:0007095 mitotic G2 DNA damage checkpoint Database 0
Category members GO Category GO:0007098 centrosome cycle Database 0
Category members GO Category GO:0007265 Ras protein signal transduction Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0014823 response to activity Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030261 chromosome condensation Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0034501 protein localization to kinetochore Database 0
Category members GO Category GO:0035173 histone kinase activity Database 0
Category members GO Category GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway Database 0
Category members GO Category GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway Database 0
Category members GO Category GO:0045740 positive regulation of DNA replication Database 0
Category members GO Category GO:0045995 regulation of embryonic development Database 0
Category members GO Category GO:0046686 response to cadmium ion Database 0
Category members GO Category GO:0046688 response to copper ion Database 0
Category members GO Category GO:0051403 stress-activated MAPK cascade Database 0
Category members GO Category GO:0055015 ventricular cardiac muscle cell development Database 0


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