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BIOCARTA_RB_PATHWAY
(Pathway_1030)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
MAPK14 2 -0.160 -0.350
CHEK1 2 -1.170 1.560
CHEK1 2 -1.170 1.560
WEE1 1 -1.790 2.530 0.694
CDC25B 0 -0.180 0.320
CDK2 0 -0.040 -0.300 -0.578 -0.797
CDK2 0 -0.040 -0.300 -0.202 -0.884 -0.107 -0.097 -0.501
YWHAH 0 0.000 0.080 1.206 0.159
YWHAH 0 0.000 0.080 0.546 0.338 0.541
CDK4 0 1.930 -0.950
CDK4 0 1.930 -0.950 -0.510 0.013
RB1 0 1.180 -1.070 0.429 0.755
RB1 0 1.180 -1.070
TP53 0 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497
ATM 0 0.398 0.474
CDC25C 0 -0.100 0.100
CDK1 0 -0.370 0.080 -0.202 -0.884 -0.107 -0.097 -0.501

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
ATM Ubiquitylation K307 -0.196 _GAYESTK(gl)WR_
ATM Ubiquitylation K331 -0.126 _GK(gl)YSSGFR_
ATM Ubiquitylation K385 -0.669 _ESSDYSVPCK(gl)R_
ATM Ubiquitylation K1101 -0.548 _LFQDTK(gl)GDSSR_
ATM Ubiquitylation K1109 -1.666 _LLK(gl)ALPLK_
ATM Ubiquitylation K1698 -1.026 _DASYTK(gl)ALK_
ATM Ubiquitylation K1738 -0.137 _SAAVTCLK(gl)NILATK_
ATM Ubiquitylation K2025 -1.497 _SIGEPDSLYGCGGGK(gl)MLQPITR_
CDC25B Phosphorylation S117 -0.601 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S118 -0.832 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S241 -2.288 -1.005 _S(ph)VTPPEEQQEAEEPK_
CDC25B Phosphorylation T243 -1.445 _SVT(ph)PPEEQQEAEEPK_
CDC25B Phosphorylation S261 0.275 _S(ph)KSLCHDEIENLLDSDHR_
CDC25B Phosphorylation S263 0.184 _SKS(ph)LCHDEIENLLDSDHR_
CDC25C Phosphorylation S185 -0.645 _YLGS(ph)PITTVPK_
CDC25C Phosphorylation S233 -0.702 -0.657 _SPS(ph)MPENLNRPR_
CDC25C Phosphorylation S280 0.256 0.326 _TVS(ph)LCDITITQMLEEDSNQGHLIGDFSK_
CDK1 Ubiquitylation K6 0.011 -0.784 _(ac)M(ox)EDYTK(gl)IEK_
CDK1 Ubiquitylation K20 -0.327 -0.270 _IGEGTYGVVYK(gl)GR_
CDK1 Ubiquitylation K33 0.736 0.239 _TTGQVVAMK(gl)K_
CDK1 Ubiquitylation K34 -0.306 _TTGQVVAMKK(gl)_
CDK1 Ubiquitylation K58 0.312 -0.262 _EISLLK(gl)ELR_
CDK1 Ubiquitylation K136 -0.468 _DLK(gl)PQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K145 0.161 -0.954 _DLKPQNLLIDDK(gl)GTIK_
CDK1 Ubiquitylation K149 -0.038 _GTIK(gl)LADFGLAR_
CDK1 Ubiquitylation K251 -0.047 -1.236 _WK(gl)PGSLASHVK_
CDK1 Ubiquitylation K280 0.179 -1.210 _MLIYDPAK(gl)R_
CDK2 Ubiquitylation K6 -0.130 -0.399 _(ac)MENFQK(gl)VEK_
CDK2 Ubiquitylation K6 0.011 -0.784 _(ac)M(ox)EDYTK(gl)IEK_
CDK2 Phosphorylation T14 0.429 _IGEGT(ph)YGVVYK_
CDK2 Phosphorylation Y15 0.697 0.743 _IGEGTY(ph)GVVYK_
CDK2 Ubiquitylation K20 0.272 _IGEGTYGVVYK(gl)AR_
CDK2 Ubiquitylation K20 -0.327 -0.270 _IGEGTYGVVYK(gl)GR_
CDK2 Ubiquitylation K24 0.366 _NK(gl)LTGEVVALKK_
CDK2 Ubiquitylation K33 0.033 _NKLTGEVVALK(gl)K_
CDK2 Ubiquitylation K33 0.736 0.239 _TTGQVVAMK(gl)K_
CDK2 Ubiquitylation K34 0.542 _LTGEVVALKK(gl)_
CDK2 Ubiquitylation K34 -0.306 _TTGQVVAMKK(gl)_
CDK2 Ubiquitylation K58 0.312 -0.262 _EISLLK(gl)ELR_
CDK2 Ubiquitylation K136 -0.468 _DLK(gl)PQNLLIDDK(gl)GTIK_
CDK2 Ubiquitylation K145 0.161 -0.954 _DLKPQNLLIDDK(gl)GTIK_
CDK2 Ubiquitylation K149 -0.038 _GTIK(gl)LADFGLAR_
CDK2 Ubiquitylation K251 -0.047 -1.236 _WK(gl)PGSLASHVK_
CDK2 Ubiquitylation K280 0.179 -1.210 _MLIYDPAK(gl)R_
CDK2 Ubiquitylation K298 -1.907 -2.380 _QDFSK(gl)VVPPLDEDGR_
CDK4 Ubiquitylation K142 -0.552 _DLK(gl)PENILVTSGGTVK_
CDK4 Ubiquitylation K211 -0.101 _K(gl)PLFCGNSEADQLGK_
CDK4 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Ubiquitylation K297 0.247 0.052 _ALQHSYLHK(gl)DEGNPE_
CDK4 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK4 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK4 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK4 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK4 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK4 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK4 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK4 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CHEK1 Ubiquitylation K53 0.879 _AVDCPENIK(gl)K_
CHEK1 Ubiquitylation K54 0.738 _AVDCPENIKK(gl)_
CHEK1 Phosphorylation S296 -0.098 0.184 _VTS(ph)GGVSESPSGFSK_
CHEK1 Phosphorylation S300 1.091 _VTSGGVS(ph)ESPSGFSK_
CHEK1 Phosphorylation S302 1.750 _VTSGGVSES(ph)PSGFSK_
CHEK1 Phosphorylation S317 1.903 _HIQSNLDFS(ph)PVNSASSEENVK_
CHEK1 Ubiquitylation K399 -0.582 _ETCEK(gl)LGYQWK_
MAPK14 Phosphorylation S2 3.221 3.623 _(ac)S(ph)QERPTFYR_
MAPK14 Phosphorylation T180 0.958 1.087 _HTDDEM(ox)T(ph)GYVATR_
MAPK14 Phosphorylation Y182 1.388 1.374 _HTDDEM(ox)TGY(ph)VATR_
MAPK14 Ubiquitylation K249 0.073 -1.380 _LVGTPGAELLKK(gl)_
RB1 Phosphorylation S69 -3.602 -3.397 _TAATAAAAAAEPPAPPPPPPPEEDPEQDS(ph)GPEDLPLVR_
RB1 Ubiquitylation K97 -0.546 _LK(gl)IPDHVR_
RB1 Phosphorylation T388 0.005 0.116 _TLQTDSIDSFETQRT(ph)PR_
RB1 Phosphorylation T405 -0.851 -0.901 _KSNLDEEVNVIPPHT(ph)PVR_
RB1 Phosphorylation S820 -0.019 _S(ph)PYKFPSSPLR_
RB1 Ubiquitylation K823 -2.214 _SPYK(gl)FPSSPLR_
RB1 Phosphorylation S827 0.824 0.111 _FPSS(ph)PLR_
RB1 Phosphorylation S839 -0.701 -1.045 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K842 -0.751 _IPGGNIYISPLK(gl)SPYK_
RB1 Phosphorylation S843 -0.701 -0.022 _IPGGNIYIS(ph)PLKS(ph)PYK_
RB1 Ubiquitylation K846 -2.084 _SPYK(gl)ISEGLPTPTK_
RB1 Phosphorylation T853 0.039 -0.555 _ISEGLPT(ph)PTKM(ox)T(ph)PR_
RB1 Ubiquitylation K856 -1.350 _ISEGLPTPTK(gl)MTPR_
RB1 Phosphorylation T858 -0.782 0.564 _ISEGLPT(ph)PTKMT(ph)PR_
RB1 Ubiquitylation K879 -0.187 _FQK(gl)INQMVCNSDR_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_
WEE1 Phosphorylation S139 -0.678 -0.613 _SPAAPYFLGSSFS(ph)PVR_
YWHAH Ubiquitylation K143 0.540 _YLAEVASGEKK(gl)_


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