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Query: CDK4

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDK4 0 0.815 1.930 -0.950
CDK4 0 0.815 1.930 -0.950 -0.510 0.013

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDK4 Phosphorylation S385 0.649 _HSSIS(ph)PVRLPLNSSLGAELSR_
CDK4 Phosphorylation T514 0.364 0.570 _DSKPIALKEEIVT(ph)PK_
CDK4 Phosphorylation S236 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Phosphorylation S249 0.095 _QDDS(ph)PSGASYGQDYDLS(ph)PSR_
CDK4 Ubiquitylation K297 0.247 0.052 _ALQHSYLHK(gl)DEGNPE_
CDK4 Phosphorylation S420 0.004 -0.202 _ES(ph)KGSPVFLPR_
CDK4 Phosphorylation S423 -0.155 -0.297 _GS(ph)PVFLPR_
CDK4 Phosphorylation T1244 -0.956 _RT(ph)PTMPQEEAAACPPHILPPEK_
CDK4 Phosphorylation S1082 -1.661 -0.980 _KETTSGTSTEPVKNS(ph)SPAPPQPAPGK_
CDK4 Phosphorylation S1083 -1.093 -1.330 _NSS(ph)PAPPQPAPGK_
CDK4 Phosphorylation T692 -0.765 -1.849 _AIT(ph)PPQQPYK_
CDK4 Phosphorylation S681 -2.532 -2.051 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Phosphorylation S685 -2.729 _HLLTDLPLPPELPGGDLS(ph)PPDS(ph)PEPK_
CDK4 Ubiquitylation K142 -0.552 _DLK(gl)PENILVTSGGTVK_
CDK4 Ubiquitylation K211 -0.101 _K(gl)PLFCGNSEADQLGK_

Background Information for CDK4:


Pubmed-CDK4 »
Uniprot-CDK4 »
Biogrid-CDK4 »
ProteomicsDB-CDK4 »

Tumorportal-CDK4 »
COSMIC-CDK4 »
GenomeRNAi-CDK4 »
Genecards-CDK4


Protein-protein Interactions for CDK4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK4 Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCND1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCND3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDKN2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OGFR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCAN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VTN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDK4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Aminoglycoside_PTrfase IPR002575 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring CDK4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3085 CCND2-CDK4 complex Database 0.11
Category members Corum 5107 p34(SEI-1)-CDK4-CyclinD2 complex Database 0.11
Category members Corum 3084 CCND1-CDK4 complex Database 0.09
Category members Corum 5287 CDK4-CCND1 complex Database 0.09
Category members Corum 312 Cell cycle kinase complex CDK4 Database 0.06
Category members Corum 1633 CyclinD1-CDK4-CDK6 complex Database 0
Category members Corum 1642 p16-cyclin D2-CDK4 complex Database 0
Category members Corum 3086 CCND3-CDK4 complex Database 0
Category members Corum 5100 CyclinD3-CDK4-CDK6 complex Database 0
Category members Corum 5101 CyclinD3-CDK4-CDK6-p21 complex Database 0


Categories featuring CDK4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_874 REACTOME_MEIOTIC_RECOMBINATION 0 3.7
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0051301 cell division Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members Pathway Pathway_845 PID_SMAD2_3NUCLEAR_PATHWAY 0 0.46
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members Pathway Pathway_41 REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 0 0.35
Category members Pathway Pathway_282 KEGG_NON_SMALL_CELL_LUNG_CANCER 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_382 KEGG_P53_SIGNALING_PATHWAY 0 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members Pathway Pathway_565 KEGG_CHRONIC_MYELOID_LEUKEMIA 0 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members Pathway Pathway_871 BIOCARTA_P53_PATHWAY 0 0.19
Category members Pathway Pathway_388 KEGG_BLADDER_CANCER 0 0.16
Category members Pathway Pathway_649 KEGG_PANCREATIC_CANCER 0 0.15
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Pathway Pathway_1171 SA_REG_CASCADE_OF_CYCLIN_EXPR 0 0.1
Category members Pathway Pathway_418 PID_ATF2_PATHWAY 0 0.08
Category members GO Category GO:0004693 cyclin-dependent protein serine/threonine kinase activity Database 0.08
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1030 BIOCARTA_RB_PATHWAY 0 0
Category members Pathway Pathway_1164 SA_G1_AND_S_PHASES 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_489 PID_NFAT_TFPATHWAY 0 0
Category members Pathway Pathway_589 BIOCARTA_RACCYCD_PATHWAY 0 0
Category members Pathway Pathway_598 KEGG_MELANOMA 0 0
Category members Pathway Pathway_656 KEGG_GLIOMA 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_970 BIOCARTA_CELLCYCLE_PATHWAY 0 0
Category members Disease phenotype Dedifferentiated_liposarcoma Dedifferentiated liposarcoma Database 0
Category members Disease phenotype Familial_melanoma Familial melanoma Database 0
Category members Disease phenotype Well-differentiated_liposarcoma Well-differentiated liposarcoma Database 0
Category members GO Category GO:0000307 cyclin-dependent protein kinase holoenzyme complex Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010288 response to lead ion Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0030332 cyclin binding Database 0
Category members GO Category GO:0033574 response to testosterone Database 0
Category members GO Category GO:0045727 positive regulation of translation Database 0
Category members GO Category GO:0045793 positive regulation of cell size Database 0
Category members GO Category GO:0055093 response to hyperoxia Database 0


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