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Query: CDC25B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CDC25B 0 -0.850 -0.180 0.320

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CDC25B Phosphorylation S261 0.275 _S(ph)KSLCHDEIENLLDSDHR_
CDC25B Phosphorylation S263 0.184 _SKS(ph)LCHDEIENLLDSDHR_
CDC25B Phosphorylation S117 -0.601 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S118 -0.832 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S241 -2.288 -1.005 _S(ph)VTPPEEQQEAEEPK_
CDC25B Phosphorylation T243 -1.445 _SVT(ph)PPEEQQEAEEPK_

Background Information for CDC25B:


Pubmed-CDC25B »
Uniprot-CDC25B »
Biogrid-CDC25B »
ProteomicsDB-CDC25B »

Tumorportal-CDC25B »
COSMIC-CDC25B »
GenomeRNAi-CDC25B »
Genecards-CDC25B


Protein-protein Interactions for CDC25B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC25B Cat. description Hein, Mann, Cell 2015
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CDC25B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members MPI_Phosphatase IPR000751 0
Category members Rhodanese-like_dom IPR001763 0


Protein complexes (CORUM database) featuring CDC25B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring CDC25B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_444 PID_P38_MK2_PATHWAY 0 0.42
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0032467 positive regulation of cytokinesis Database 0.35
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_982 BIOCARTA_G2_PATHWAY 0 0.24
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members Pathway Pathway_1029 BIOCARTA_SRCRPTP_PATHWAY 0 0.08
Category members Pathway Pathway_971 REACTOME_CYCLIN_A_B1_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION 0 0.06
Category members GO Category GO:0045860 positive regulation of protein kinase activity Database 0.06
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0007144 female meiosis I Database 0.04
Category members Pathway Pathway_1030 BIOCARTA_RB_PATHWAY 0 0
Category members Pathway Pathway_715 KEGG_MAPK_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_969 BIOCARTA_PTC1_PATHWAY 0 0
Category members Pathway Pathway_972 SA_G2_AND_M_PHASES 0 0
Category members GO Category GO:0000087 mitotic M phase Database 0
Category members GO Category GO:0001556 oocyte maturation Database 0
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0035335 peptidyl-tyrosine dephosphorylation Database 0


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