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PID_AURORA_A_PATHWAY
(Pathway_985)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
BRCA1 2 0.200 -0.140 0.433 0.018 0.146
GSK3B 2 1.020 -0.870 -1.128 1.091
PPP2R5D 1 -0.110 0.620
PPP2R5D 1 -0.110 0.620 -0.455 -0.019
DLGAP5 1 -2.380 4.820 -0.852
RAN 1 0.795 0.949 -0.688 0.566 0.288
TACC1 1 -0.060 -0.800
TACC3 0 1.030 -0.910
PRKACA 0 0.380 -0.680 -1.005 -0.697 0.234 0.487
AURKA 0 -0.450 -0.060 -2.905 -1.603
TPX2 0 -0.652 -0.369
TPX2 0 -0.850 0.408
BIRC5 0 -0.309 -0.536
CDC25B 0 -0.180 0.320
ARHGEF7 0 -0.410 -0.070
FZR1 0 0.740 -0.470
GIT1 0 0.720 -0.330 -1.751 0.439
GADD45A 0 1.050 -0.170
MDM2 0 -0.210 0.080
TP53 0 -1.070 1.050 -2.808 0.076 -0.094 0.436 0.497
AKT1 0 -0.050 0.700
AKT1 0 0.860 -0.040
PAK1 0 1.190 -0.630
NDEL1 0 0.150 -0.130
CKAP5 0 0.237 -1.027 -0.242 -0.255 -0.192
AURKAIP1 0 1.650 -1.420
AURKB 0 -0.840 1.170 -0.562 -0.744 -0.302
TDRD7 0 -0.390 1.130

PTM Sites:

Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AKT1 Phosphorylation S124 0.252 0.311 _SGS(ph)PSDNSGAEEMEVSLAKPK_
AKT1 Phosphorylation S126 -0.241 _SGSPS(ph)DNSGAEEM(ox)EVSLAK_
AKT1 Ubiquitylation K301 0.988 _EGIK(gl)DGATMK_
ARHGEF7 Phosphorylation S50 1.374 1.424 _IKS(ph)FDSLGSQSLHTR_
ARHGEF7 Phosphorylation S154 -0.198 0.140 _SGTLKS(ph)PPK_
ARHGEF7 Phosphorylation S415 0.662 0.947 _M(ox)S(ph)GFIYQGK_
ARHGEF7 Phosphorylation S600 0.797 _S(ph)TAALEEDAQILK_
ARHGEF7 Phosphorylation T601 0.797 _S(ph)TAALEEDAQILK_
ARHGEF7 Phosphorylation S635 0.061 -0.203 _KES(ph)APQVLLPEEEKIIVEETK_
AURKAIP1 Ubiquitylation K183 -0.748 _AGLK(gl)EAPEGWQTPK_
AURKB Ubiquitylation K56 -2.018 -2.920 _SNVQPTAAPGQK(gl)VMENSSGTPDILTR_
AURKB Ubiquitylation K87 -0.700 -1.401 _GK(gl)FGNVYLAR_
AURKB Ubiquitylation K164 -1.041 _GELYK(gl)ELQK_
AURKB Ubiquitylation K168 -0.421 -1.027 _ELQK(gl)SCTFDEQR_
AURKB Ubiquitylation K287 -0.625 _IVK(gl)VDLK_
BIRC5 Ubiquitylation K15 -1.446 _(ac)GAPTLPPAWQPFLK(gl)DHR_
BIRC5 Ubiquitylation K113 0.088 -0.061 _HSSGCAFLSVK(gl)K_
BIRC5 Ubiquitylation K114 -0.061 _HSSGCAFLSVK(gl)K_
BRCA1 Phosphorylation S123 0.465 0.445 _KENNSPEHLKDEVS(ph)IIQSM(ox)GYR_
BRCA1 Phosphorylation S753 2.662 4.077 _VSNNAEDPKDLMLS(ph)GER_
BRCA1 Phosphorylation S1009 0.733 1.028 _KNLLEENFEEHSM(ox)S(ph)PER_
BRCA1 Phosphorylation S1546 1.821 2.105 _NYPS(ph)QEELIK_
BRCA1 Phosphorylation S1564 3.065 _VVDVEEQQLEES(ph)GPHDLTETSYLPR_
BRCA1 Phosphorylation S1664 1.120 _EKPELTAS(ph)TER_
CDC25B Phosphorylation S117 -0.601 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S118 -0.832 _EAFAQRPS(ph)SAPDLMCLSPDR_
CDC25B Phosphorylation S241 -2.288 -1.005 _S(ph)VTPPEEQQEAEEPK_
CDC25B Phosphorylation T243 -1.445 _SVT(ph)PPEEQQEAEEPK_
CDC25B Phosphorylation S261 0.275 _S(ph)KSLCHDEIENLLDSDHR_
CDC25B Phosphorylation S263 0.184 _SKS(ph)LCHDEIENLLDSDHR_
CKAP5 Ubiquitylation K1075 1.056 _DQVLAMLEK(gl)AK_
CKAP5 Ubiquitylation K1077 1.056 _DQVLAMLEK(gl)AK_
DLGAP5 Phosphorylation T661 -0.604 _NEMGIPQQTT(ph)SPENAGPQNTK_
DLGAP5 Phosphorylation S662 -1.032 -0.577 _NEMGIPQQTTS(ph)PENAGPQNTK_
DLGAP5 Phosphorylation S689 -0.077 -0.102 _S(ph)SIEDAQCPGLPDLIEENHVVNK_
DLGAP5 Phosphorylation S690 -0.077 -0.395 _S(ph)SIEDAQCPGLPDLIEENHVVNK_
DLGAP5 Phosphorylation S774 1.237 _NTAS(ph)QNSILEEGETK_
DLGAP5 Phosphorylation S806 0.216 _SLTTECHLLDS(ph)PGLNCSNPFTQLER_
FZR1 Ubiquitylation K135 -0.177 _GLFTYSLSTK(gl)R_
FZR1 Ubiquitylation K263 0.187 _GFVQIWDAAAGKK(gl)_
GADD45A Ubiquitylation K12 -0.515 0.281 _TLEEFSAGEQK(gl)TER_
GADD45A Ubiquitylation K29 0.092 _VGDALEEVLSK(gl)ALSQR_
GIT1 Phosphorylation S374 1.018 1.475 _SLS(ph)SPTDNLELSLR_
GIT1 Phosphorylation S375 0.909 1.262 _SLSS(ph)PTDNLELSLR_
GIT1 Phosphorylation S401 0.624 0.935 _SQSDLDDQHDYDSVAS(ph)DEDTDQEPLR_
GIT1 Phosphorylation S423 0.332 0.924 _ARS(ph)MDSSDLSDGAVTLQEYLELKK_
GIT1 Phosphorylation S605 0.173 0.037 _HGS(ph)GADSDYENTQSGDPLLGLEGK_
GSK3B Phosphorylation S9 -0.483 0.010 _TTS(ph)FAESCKPVQQPSAFGSMK_
GSK3B Ubiquitylation K85 -0.204 _LCDSGELVAIK(gl)K_
GSK3B Ubiquitylation K86 -0.204 _LCDSGELVAIK(gl)K_
GSK3B Phosphorylation S215 0.296 0.477 _GEPNVS(ph)YICSR_
GSK3B Phosphorylation Y216 0.356 0.376 _GEPNVSY(ph)ICSR_
GSK3B Phosphorylation T390 2.800 2.527 _IQAAAST(ph)PTNATAASDANTGDR_
MDM2 Phosphorylation S166 0.576 1.068 _AIS(ph)ETEENSDELSGER_
MDM2 Ubiquitylation K334 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K336 -0.872 _ENWLPEDK(gl)GK_
MDM2 Ubiquitylation K363 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K364 0.883 _LENSTQAEEGFDVPDCK(gl)K_
MDM2 Ubiquitylation K473 0.806 _NK(gl)PCPVCR_
NDEL1 Phosphorylation S249 -0.120 _S(ph)APSS(ph)PTLDCEK_
NDEL1 Phosphorylation S253 -0.120 _S(ph)APSS(ph)PTLDCEK_
PAK1 Phosphorylation S174 -1.439 -0.597 _AVSETPAVPPVS(ph)EDEDDDDDDATPPPVIAPRPEHTK_
PAK1 Phosphorylation T212 0.312 _SVIEPLPVT(ph)PTR_
PAK1 Phosphorylation T219 -0.560 -0.962 _DVAT(ph)SPISPTENNTT(ph)PPDALTR_
PAK1 Phosphorylation S220 -0.916 -0.774 _DVATS(ph)PISPTENNTTPPDALTR_
PAK1 Phosphorylation S223 1.033 0.153 _DVATSPIS(ph)PTENNTTPPDALTR_
PAK1 Phosphorylation T225 -1.278 _DVATSPISPT(ph)ENNTTPPDALTR_
PAK1 Phosphorylation T230 -1.418 -1.502 _DVATSPISPTENNTT(ph)PPDALTR_
PPP2R5D Phosphorylation T63 -1.449 _RPSNST(ph)PPPTQLSK_
PPP2R5D Ubiquitylation K232 -0.302 _FLESPDFQPNIAK(gl)K_
PPP2R5D Ubiquitylation K233 -0.302 0.665 _FLESPDFQPNIAKK(gl)_
PPP2R5D Ubiquitylation K409 -0.010 _QLAK(gl)CVSSPHFQVAER_
PPP2R5D Phosphorylation S573 0.524 0.357 _RKS(ph)ELPQDVYTIK_
PPP2R5D Phosphorylation S598 -0.317 1.858 _RAEEFLTAS(ph)QEAL_
PRKACA Ubiquitylation K30 -0.143 _AKEDFLKK(gl)_
PRKACA Ubiquitylation K93 0.839 0.714 _QIEHTLNEK(gl)R_
RAN Ubiquitylation K23 0.056 _LVLVGDGGTGK(gl)TTFVK_
RAN Ubiquitylation K37 0.841 _HLTGEFEK(gl)K_
RAN Ubiquitylation K60 -0.488 0.477 _GPIK(gl)FNVWDTAGQEK_
RAN Ubiquitylation K71 1.279 _FNVWDTAGQEK(gl)FGGLR_
RAN Ubiquitylation K116 -0.044 1.823 _VTYK(gl)NVPNWHR_
RAN Ubiquitylation K140 -0.020 0.586 _VCENIPIVLCGNK(gl)VDIK_
RAN Ubiquitylation K144 0.131 0.529 _VCENIPIVLCGNKVDIK(gl)DR_
RAN Ubiquitylation K147 0.000 _VCENIPIVLCGNKVDIKDRK(gl)_
RAN Ubiquitylation K151 1.342 0.712 _AK(gl)SIVFHR_
RAN Ubiquitylation K158 0.185 0.370 _K(gl)KNLQYYDISAK_
RAN Ubiquitylation K159 0.246 0.274 _K(gl)NLQYYDISAK_
RAN Ubiquitylation K176 1.593 _SNYNFEK(gl)PFLWLAR_
TACC1 Phosphorylation S44 -0.293 -0.032 _GGAAGEDEAGGPEGDPEEEDS(ph)QAETK_
TACC1 Phosphorylation S91 0.291 1.551 _S(ph)QESQEADEQLVAEVVEK_
TACC1 Phosphorylation S94 1.530 _SQES(ph)QEADEQLVAEVVEK_
TACC3 Phosphorylation S25 -0.993 -0.186 _NTENCDFLFS(ph)PPEVTGR_
TACC3 Phosphorylation T59 -2.436 _VTFQT(ph)PLRDPQTHR_
TACC3 Phosphorylation S71 0.876 1.139 _ILS(ph)PSMASK_
TACC3 Phosphorylation S175 0.134 0.059 _VS(ph)GSPEQAVEENLSSYSLDR_
TACC3 Phosphorylation S177 0.248 0.430 _VSGS(ph)PEQAVEENLSSYSLDRR_
TACC3 Phosphorylation T228 0.779 _AETPHGAEEECKAET(ph)PHGAEEECR_
TACC3 Phosphorylation T249 -0.679 -0.649 _HGGVCAPAAVAT(ph)SPPGAIPK_
TACC3 Phosphorylation S250 -0.740 -0.589 _HGGVCAPAAVATS(ph)PPGAIPK_
TACC3 Phosphorylation T315 1.424 _AM(ox)T(ph)LSPQEEVAAGQMASSSR_
TACC3 Phosphorylation S317 1.040 1.242 _AM(ox)TLS(ph)PQEEVAAGQM(ox)ASSSR_
TACC3 Phosphorylation S434 0.179 0.184 _SGCSEAQPPES(ph)PETR_
TACC3 Ubiquitylation K649 -0.831 _DLDAVVK(gl)ATQEENR_
TACC3 Ubiquitylation K819 0.067 _TK(gl)ENEELTR_
TDRD7 Ubiquitylation K576 0.029 1.028 _FCSLSFQATK(gl)CK_
TP53 Ubiquitylation K120 -0.188 _LGFLHSGTAK(gl)SVTCTYSPALNK_
TP53 Ubiquitylation K164 0.157 -1.260 _AMAIYK(gl)QSQHMTEVVR_
TP53 Phosphorylation S314 -0.695 -1.000 _ALPNNTSS(ph)SPQPK_
TP53 Phosphorylation S315 -0.762 -0.959 _RALPNNTSSS(ph)PQPK_
TP53 Ubiquitylation K320 -0.978 _ALPNNTSSSPQPKK(gl)_
TP53 Ubiquitylation K357 -0.231 -0.823 _ELNEALELKDAQAGK(gl)EPGGSR_
TPX2 Phosphorylation T72 -1.259 _ANLQQAIVT(ph)PLKPVDNTYYK_
TPX2 Phosphorylation T405 -2.166 _DPQT(ph)PVLQTK_
TPX2 Ubiquitylation K640 -0.320 0.644 _GALK(gl)AQTWK_
TPX2 Ubiquitylation K763 -0.340 _YQGLEIK(gl)SSDQPLTVPVSPK_
TPX2 Phosphorylation T770 -1.331 _SSDQPLT(ph)VPVSPK_
TPX2 Phosphorylation S774 -1.173 -0.922 _SSDQPLTVPVS(ph)PK_


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