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Query: TPX2

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TPX2 0 -3.234 -0.850 0.408
TPX2 0 -3.234 -0.652 -0.369

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TPX2 Ubiquitylation K640 -0.320 0.644 _GALK(gl)AQTWK_
TPX2 Phosphorylation S774 -1.173 -0.922 _SSDQPLTVPVS(ph)PK_
TPX2 Phosphorylation T72 -1.259 _ANLQQAIVT(ph)PLKPVDNTYYK_
TPX2 Phosphorylation T770 -1.331 _SSDQPLT(ph)VPVSPK_
TPX2 Phosphorylation T405 -2.166 _DPQT(ph)PVLQTK_
TPX2 Ubiquitylation K763 -0.340 _YQGLEIK(gl)SSDQPLTVPVSPK_

Background Information for TPX2:


Pubmed-TPX2 »
Uniprot-TPX2 »
Biogrid-TPX2 »
ProteomicsDB-TPX2 »

Tumorportal-TPX2 »
COSMIC-TPX2 »
GenomeRNAi-TPX2 »
Genecards-TPX2


Protein-protein Interactions for TPX2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RAB7A Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSTM3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF111 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TPX2
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring TPX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TPX2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005874 microtubule Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0005819 spindle Database 0.41
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members Pathway Pathway_1255 BIOCARTA_RANMS_PATHWAY 0 0.35
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members Pathway Pathway_386 ST_FAS_SIGNALING_PATHWAY 0 0.02
Category members GO Category GO:0032147 activation of protein kinase activity Database 0
Category members GO Category GO:0060236 regulation of mitotic spindle organization Database 0


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