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Query: RAN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RAN 1 5.075 0.795 0.949 -0.688 0.566 0.288

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RAN Ubiquitylation K116 -0.044 1.823 _VTYK(gl)NVPNWHR_
RAN Ubiquitylation K176 1.593 _SNYNFEK(gl)PFLWLAR_
RAN Ubiquitylation K151 1.342 0.712 _AK(gl)SIVFHR_
RAN Ubiquitylation K140 -0.020 0.586 _VCENIPIVLCGNK(gl)VDIK_
RAN Ubiquitylation K144 0.131 0.529 _VCENIPIVLCGNKVDIK(gl)DR_
RAN Ubiquitylation K60 -0.488 0.477 _GPIK(gl)FNVWDTAGQEK_
RAN Ubiquitylation K158 0.185 0.370 _K(gl)KNLQYYDISAK_
RAN Ubiquitylation K159 0.246 0.274 _K(gl)NLQYYDISAK_
RAN Ubiquitylation K23 0.056 _LVLVGDGGTGK(gl)TTFVK_
RAN Ubiquitylation K37 0.841 _HLTGEFEK(gl)K_
RAN Ubiquitylation K71 1.279 _FNVWDTAGQEK(gl)FGGLR_
RAN Ubiquitylation K147 0.000 _VCENIPIVLCGNKVDIKDRK(gl)_

Background Information for RAN:


Pubmed-RAN »
Uniprot-RAN »
Biogrid-RAN »
ProteomicsDB-RAN »

Tumorportal-RAN »
COSMIC-RAN »
GenomeRNAi-RAN »
Genecards-RAN


Protein-protein Interactions for RAN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC88A Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IMMT Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF1C Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait PAX6 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RANBP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBE2I Cat. description Hein, Mann, Cell 2015
Category members IP bait AKIRIN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UBE2I Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RAN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Ran_GTPase IPR002041 1.25
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Small_GTPase_Ras IPR020849 0.7
Category members Small_GTPase_Rho IPR003578 0.65
Category members Small_GTPase IPR001806 0.65
Category members Small_GTPase_Rab_type IPR003579 0.51
Category members MIRO-like IPR013684 0.4
Category members Small_GTP-bd_dom IPR005225 0.32


Protein complexes (CORUM database) featuring RAN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 1554 RANBP1-RAN-KPNB1 complex Database 0.82
Category members Corum 1176 CRM1-RAN-PHAX-CBC complex (cap binding complex) Database 0.57
Category members Corum 1045 Snurportin-CRM1-RanGTP complex Database 0.11
Category members Corum 1551 IPO13-RAN-EIF1AX complex Database 0.08
Category members Corum 1552 TNPO2-RAN-NXF1 complex Database 0


Categories featuring RAN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0019058 viral life cycle Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members Pathway Pathway_1311 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY 0 7.24
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0006913 nucleocytoplasmic transport Database 2.96
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members Pathway Pathway_1254 PID_RANBP2_PATHWAY 0 1.33
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0030036 actin cytoskeleton organization Database 1.08
Category members Pathway Pathway_118 PID_FOXO_PATHWAY 0 0.97
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0007052 mitotic spindle organization Database 0.41
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members Pathway Pathway_1255 BIOCARTA_RANMS_PATHWAY 0 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_1143 PID_HDAC_CLASSII_PATHWAY 0 0.3
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006405 RNA export from nucleus Database 0.24
Category members Pathway Pathway_368 REACTOME_MICRORNA_MIRNA_BIOGENESIS 0 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_379 REACTOME_REGULATORY_RNA_PATHWAYS 0 0.12
Category members GO Category GO:0050681 androgen receptor binding Database 0.12
Category members Pathway Pathway_1051 PID_NFKAPPAB_CANONICAL_PATHWAY 0 0
Category members GO Category GO:0006259 DNA metabolic process Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0034629 cellular protein complex localization Database 0


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