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Query: GSK3B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GSK3B 2 5.086 1.020 -0.870 -1.128 1.091

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GSK3B Phosphorylation T390 2.800 2.527 _IQAAAST(ph)PTNATAASDANTGDR_
GSK3B Phosphorylation S215 0.296 0.477 _GEPNVS(ph)YICSR_
GSK3B Phosphorylation Y216 0.356 0.376 _GEPNVSY(ph)ICSR_
GSK3B Phosphorylation S9 -0.483 0.010 _TTS(ph)FAESCKPVQQPSAFGSMK_
GSK3B Ubiquitylation K85 -0.204 _LCDSGELVAIK(gl)K_
GSK3B Ubiquitylation K86 -0.204 _LCDSGELVAIK(gl)K_

Background Information for GSK3B:


Pubmed-GSK3B »
Uniprot-GSK3B »
Biogrid-GSK3B »
ProteomicsDB-GSK3B »

Tumorportal-GSK3B »
COSMIC-GSK3B »
GenomeRNAi-GSK3B »
Genecards-GSK3B


Protein-protein Interactions for GSK3B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AXIN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FRAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GSK3B Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP3CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RCAN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SAMHD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSKS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GSK3B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring GSK3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3166 AXIN-APC-betaCatenin-GSK3B complex Database 0.52
Category members Corum 757 Prune-GSK3beta complex Database 0.08
Category members Corum 2998 Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex Database 0.06


Categories featuring GSK3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_934 PID_PI3KCI_AKT_PATHWAY 0 2.5
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members Pathway Pathway_636 PID_PI3K_PLC_TRK_PATHWAY 0 1.85
Category members Pathway Pathway_924 PID_ILK_PATHWAY 0 1.75
Category members Pathway Pathway_455 PID_INSULIN_GLUCOSE_PATHWAY 0 1.7
Category members GO Category GO:0006349 regulation of gene expression by genetic imprinting Database 1.64
Category members GO Category GO:0030426 growth cone Database 1.61
Category members Pathway Pathway_1023 PID_NFAT_3PATHWAY 0 1.46
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members Pathway Pathway_634 KEGG_COLORECTAL_CANCER 0 0.98
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0043198 dendritic shaft Database 0.93
Category members GO Category GO:0030010 establishment of cell polarity Database 0.91
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members GO Category GO:0043197 dendritic spine Database 0.86
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members GO Category GO:0005813 centrosome Database 0.75
Category members Pathway Pathway_529 KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 0 0.75
Category members GO Category GO:0031334 positive regulation of protein complex assembly Database 0.69
Category members Pathway Pathway_568 PID_CDC42_PATHWAY 0 0.68
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_671 PID_WNT_CANONICAL_PATHWAY 0 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_509 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES 0 0.62
Category members Pathway Pathway_1142 PID_LKB1_PATHWAY 0 0.6
Category members Pathway Pathway_840 ST_WNT_BETA_CATENIN_PATHWAY 0 0.6
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_985 PID_AURORA_A_PATHWAY 0 0.34
Category members Pathway Pathway_408 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0 0.32
Category members GO Category GO:0030877 beta-catenin destruction complex Database 0.31
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0032886 regulation of microtubule-based process Database 0.29
Category members Pathway Pathway_1176 BIOCARTA_PITX2_PATHWAY 0 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_1173 BIOCARTA_PS1_PATHWAY 0 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0043227 membrane-bounded organelle Database 0.25
Category members GO Category GO:0051059 NF-kappaB binding Database 0.25
Category members Pathway Pathway_587 KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_535 SIG_BCR_SIGNALING_PATHWAY 0 0.24
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0035372 protein localization to microtubule Database 0.23
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members GO Category GO:0016310 phosphorylation Database 0.21
Category members GO Category GO:0044027 hypermethylation of CpG island Database 0.21
Category members GO Category GO:0044337 canonical Wnt signaling pathway involved in positive regulation of apoptotic process Database 0.21
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members Pathway Pathway_533 KEGG_ENDOMETRIAL_CANCER 0 0.21
Category members Pathway Pathway_648 KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 0 0.19
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_1141 BIOCARTA_P35ALZHEIMERS_PATHWAY 0 0.19
Category members Pathway Pathway_165 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 0 0.18
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members GO Category GO:0000320 re-entry into mitotic cell cycle Database 0.17
Category members GO Category GO:0034236 protein kinase A catalytic subunit binding Database 0.14
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0007520 myoblast fusion Database 0.11
Category members GO Category GO:0048156 tau protein binding Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members Pathway Pathway_984 PID_HEDGEHOG_GLI_PATHWAY 0 0.1
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members GO Category GO:0005977 glycogen metabolic process Database 0.08
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0050321 tau-protein kinase activity Database 0.04
Category members Pathway Pathway_1034 KEGG_AXON_GUIDANCE 0 0.04
Category members Pathway Pathway_1151 KEGG_HEDGEHOG_SIGNALING_PATHWAY 0 0.04
Category members GO Category GO:0033138 positive regulation of peptidyl-serine phosphorylation Database 0.03
Category members GO Category GO:0046827 positive regulation of protein export from nucleus Database 0.03
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members Pathway Pathway_1175 PID_BETA_CATENIN_DEG_PATHWAY 0 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_558 PID_REELIN_PATHWAY 0 0.01
Category members Pathway Pathway_1133 PID_BMP_PATHWAY 0 0
Category members Pathway Pathway_1154 BIOCARTA_SHH_PATHWAY 0 0
Category members Pathway Pathway_1163 KEGG_BASAL_CELL_CARCINOMA 0 0
Category members Pathway Pathway_209 PID_DELTA_NP63_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_244 KEGG_MELANOGENESIS 0 0
Category members Pathway Pathway_252 KEGG_CHEMOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_522 PID_KIT_PATHWAY 0 0
Category members Pathway Pathway_575 KEGG_ERBB_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_633 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES 0 0
Category members Pathway Pathway_641 BIOCARTA_NFAT_PATHWAY 0 0
Category members Pathway Pathway_745 BIOCARTA_G1_PATHWAY 0 0
Category members Pathway Pathway_872 BIOCARTA_ALK_PATHWAY 0 0
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0001954 positive regulation of cell-matrix adhesion Database 0
Category members GO Category GO:0006611 protein export from nucleus Database 0
Category members GO Category GO:0006983 ER overload response Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0009887 organ morphogenesis Database 0
Category members GO Category GO:0010226 response to lithium ion Database 0
Category members GO Category GO:0010614 negative regulation of cardiac muscle hypertrophy Database 0
Category members GO Category GO:0010800 positive regulation of peptidyl-threonine phosphorylation Database 0
Category members GO Category GO:0014902 myotube differentiation Database 0
Category members GO Category GO:0016477 cell migration Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0021766 hippocampus development Database 0
Category members GO Category GO:0031333 negative regulation of protein complex assembly Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032855 positive regulation of Rac GTPase activity Database 0
Category members GO Category GO:0035255 ionotropic glutamate receptor binding Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0036016 cellular response to interleukin-3 Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043407 negative regulation of MAP kinase activity Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0045719 negative regulation of glycogen biosynthetic process Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0048168 regulation of neuronal synaptic plasticity Database 0
Category members GO Category GO:0050774 negative regulation of dendrite morphogenesis Database 0
Category members GO Category GO:0051534 negative regulation of NFAT protein import into nucleus Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0071109 superior temporal gyrus development Database 0
Category members GO Category GO:0071260 cellular response to mechanical stimulus Database 0


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