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BIOCARTA_IGF1MTOR_PATHWAY
(Pathway_508)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPS6 5 -1.590 2.890 0.202 -0.347 -0.009 -0.153 0.152
GSK3B 2 1.020 -0.870 -1.128 1.091
EIF2S2 2 -2.220 4.160 1.238 -0.784 0.387 0.537
EIF2S2 2 -2.220 4.160 -0.289
EIF2S3 1 0.380 0.280 0.168
EIF2S3 1 0.380 0.280 0.842 -0.253 0.010
IGF1R 1 -0.490 0.750 1.476 0.714
EIF4E 1 -2.250 4.200 0.590 0.156
EIF4E 1 -2.250 4.200 0.369
EIF4EBP1 1 2.050 -1.320
PDK2 0 0.920 -0.730
RPS6KB1 0 0.850 -0.600
PPP2CA 0 0.160 -0.540 0.194 0.044 0.215
PPP2CA 0 0.160 -0.540 0.650 1.189
PIK3CA 0
EIF2S1 0 -0.440 -0.030 0.648 0.346 0.497
PDPK1 0 0.050 -0.440
AKT1 0 -0.050 0.700
AKT1 0 0.860 -0.040
EIF2B5 0 -0.630 0.250 -0.711 0.154 -0.822
PIK3R1 0 1.910 -1.220 -0.441 0.147
INPPL1 0 1.690 -0.810
MTOR 0 -0.680 0.150 0.757 0.074 0.101

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AKT1 Phosphorylation S124 0.252 0.311 _SGS(ph)PSDNSGAEEMEVSLAKPK_
AKT1 Phosphorylation S126 -0.241 _SGSPS(ph)DNSGAEEM(ox)EVSLAK_
AKT1 Ubiquitylation K301 0.988 _EGIK(gl)DGATMK_
EIF2B5 Phosphorylation S544 0.200 0.349 _GGS(ph)PQM(ox)DDIK_
EIF2S1 Ubiquitylation K87 -0.040 _GYIDLSK(gl)R_
EIF2S1 Ubiquitylation K101 -0.331 0.258 _CEDK(gl)FTK_
EIF2S1 Ubiquitylation K106 0.463 0.148 _SK(gl)TVYSILR_
EIF2S1 Ubiquitylation K190 -1.695 _LTPQAVK(gl)IR_
EIF2S1 Ubiquitylation K226 -0.401 -2.300 _AGLNCSTENMPIK(gl)INLIAPPR_
EIF2S2 Phosphorylation S2 0.392 0.407 _(ac)S(ph)GDEM(ox)IFDPTM(ox)SKK_
EIF2S2 Phosphorylation S105 0.614 0.180 _DLKIES(ph)DVQEPTEPEDDLDIMLGNK_
EIF2S2 Phosphorylation T111 0.393 -0.207 _IESDVQEPT(ph)EPEDDLDIMLGNKK_
EIF2S2 Ubiquitylation K190 -1.188 _EK(gl)NPDMVAGEK_
EIF2S2 Ubiquitylation K199 0.815 _EKNPDMVAGEK(gl)R_
EIF2S2 Ubiquitylation K265 1.379 _FQQK(gl)QIENVLR_
EIF2S2 Ubiquitylation K276 4.065 _YIK(gl)EYVTCHTCR_
EIF2S2 Ubiquitylation K293 -0.051 0.495 _SPDTILQK(gl)DTR_
EIF2S2 Ubiquitylation K324 0.924 0.471 _TGFQAVTGK(gl)R_
EIF2S3 Ubiquitylation K59 0.426 0.672 _STVVK(gl)AISGVHTVR_
EIF2S3 Ubiquitylation K70 -0.136 0.775 _FK(gl)NELER_
EIF2S3 Ubiquitylation K80 0.618 _NITIK(gl)LGYANAK_
EIF2S3 Ubiquitylation K87 -0.553 1.040 _LGYANAK(gl)IYK_
EIF2S3 Ubiquitylation K90 -1.279 -0.619 _IYK(gl)LDDPSCPRPECYR_
EIF2S3 Ubiquitylation K121 -1.264 0.000 _SCGSSTPDEFPTDIPGTK(gl)GNFK_
EIF2S3 Ubiquitylation K125 -0.886 1.674 _GNFK(gl)LVR_
EIF2S3 Ubiquitylation K196 -0.225 0.792 _IDLVK(gl)ESQAK_
EIF2S3 Ubiquitylation K275 0.154 _SFDVNKPGCEVDDLK(gl)GGVAGGSILK_
EIF2S3 Ubiquitylation K285 0.689 _GGVAGGSILK(gl)GVLK_
EIF2S3 Ubiquitylation K303 -0.429 0.020 _VGQEIEVRPGIVSK(gl)DSEGK_
EIF2S3 Ubiquitylation K308 -1.136 0.216 _DSEGK(gl)LMCKPIFSK_
EIF2S3 Ubiquitylation K312 -0.523 0.555 _LMCK(gl)PIFSK_
EIF2S3 Ubiquitylation K391 0.111 _LLGVRTEGDKK(gl)_
EIF2S3 Ubiquitylation K421 0.258 1.210 _VSAVK(gl)ADLGK_
EIF2S3 Ubiquitylation K440 0.386 1.041 _IVLTNPVCTEVGEK(gl)IALSR_
EIF2S3 Ubiquitylation K466 -0.588 0.203 _GVTIK(gl)PTVDDD_
EIF4E Ubiquitylation K147 -0.433 0.065 _WLITLNK(gl)QQR_
EIF4EBP1 Phosphorylation Y34 -1.060 _RVVLGDGVQLPPGDY(ph)STTPGGTLFS(ph)TTPGGTR_
EIF4EBP1 Phosphorylation S35 -0.849 _RVVLGDGVQLPPGDYS(ph)TTPGGTLFS(ph)TTPGGTR_
EIF4EBP1 Phosphorylation T37 -0.768 -0.583 _RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR_
EIF4EBP1 Phosphorylation T41 -3.655 -0.903 _RVVLGDGVQLPPGDYST(ph)TPGGT(ph)LFSTTPGGTR_
EIF4EBP1 Phosphorylation S44 -0.796 _VVLGDGVQLPPGDYSTTPGGTLFS(ph)T(ph)TPGGTR_
EIF4EBP1 Phosphorylation T45 -0.727 _VVLGDGVQLPPGDYSTTPGGTLFS(ph)T(ph)TPGGTR_
EIF4EBP1 Phosphorylation T46 -0.890 -0.817 _RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR_
EIF4EBP1 Phosphorylation S65 0.522 0.478 _NS(ph)PVTKT(ph)PPR_
EIF4EBP1 Phosphorylation T68 -1.621 -2.402 _NS(ph)PVT(ph)KTPPRDLPTIPGVTSPSSDEPPMEASQSHLR_
EIF4EBP1 Ubiquitylation K69 -1.171 -1.547 _NSPVTK(gl)TPPR_
EIF4EBP1 Phosphorylation T70 -0.702 -0.017 _NSPVTKT(ph)PPR_
EIF4EBP1 Phosphorylation T77 -1.921 -1.898 _TPPRDLPT(ph)IPGVTSPSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation T82 1.253 _DLPTIPGVT(ph)SPSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation S83 1.211 0.339 _DLPTIPGVTS(ph)PSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation S96 -1.541 _DLPTIPGVTSPSSDEPPMEASQS(ph)HLRNSPEDK_
EIF4EBP1 Phosphorylation S101 -1.900 -1.976 _DLPTIPGVTSPSSDEPPMEASQSHLRNS(ph)PEDK_
GSK3B Phosphorylation S9 -0.483 0.010 _TTS(ph)FAESCKPVQQPSAFGSMK_
GSK3B Ubiquitylation K85 -0.204 _LCDSGELVAIK(gl)K_
GSK3B Ubiquitylation K86 -0.204 _LCDSGELVAIK(gl)K_
GSK3B Phosphorylation S215 0.296 0.477 _GEPNVS(ph)YICSR_
GSK3B Phosphorylation Y216 0.356 0.376 _GEPNVSY(ph)ICSR_
GSK3B Phosphorylation T390 2.800 2.527 _IQAAAST(ph)PTNATAASDANTGDR_
IGF1R Ubiquitylation K47 1.146 _NDYQQLK(gl)R_
IGF1R Ubiquitylation K1033 5.779 _VAIK(gl)TVNEAASMR_
IGF1R Ubiquitylation K1168 0.191 _K(gl)GGKGLLPVR_
IGF1R Ubiquitylation K1171 0.232 _GGK(gl)GLLPVR_
INPPL1 Phosphorylation S1003 -1.290 _NSFNNPAYYVLEGVPHQLLPPEPPS(ph)PAR_
MTOR Ubiquitylation K309 -0.762 0.065 _DLMGFGTK(gl)PR_
MTOR Ubiquitylation K1257 -1.167 -0.901 _SGQGDALASGPVETGPMKK(gl)_
MTOR Ubiquitylation K1395 -1.255 _AYAK(gl)ALHYK_
MTOR Ubiquitylation K2066 -1.004 _GPQTLK(gl)ETSFNQAYGR_
MTOR Ubiquitylation K2166 -1.304 _IQSIAPSLQVITSK(gl)QRPR_
MTOR Phosphorylation T2471 0.329 _KT(ph)GTTVPESIHSFIGDGLVKPEALNK_
PDK2 Ubiquitylation K376 -0.374 _LPVYNK(gl)SAWR_
PDPK1 Phosphorylation S241 0.358 0.361 _ANS(ph)FVGTAQYVSPELLTEK_
PDPK1 Ubiquitylation K257 0.571 -0.234 _ANSFVGTAQYVSPELLTEK(gl)SACK_
PIK3CA Ubiquitylation K864 0.390 0.588 _NSHTIM(ox)QIQCK(gl)GGLK_
PIK3CA Ubiquitylation K868 0.204 0.651 _NSHTIM(ox)QIQCKGGLK(gl)_
PIK3CA Ubiquitylation K974 -0.273 _GAQECTK(gl)TREFER_
PPP2CA Ubiquitylation K4 -0.788 -0.378 _(ac)MDDK(gl)AFTK_
PPP2CA Ubiquitylation K4 -0.450 -0.016 _(ac)M(ox)DEK(gl)VFTK_
PPP2CA Ubiquitylation K8 -0.522 _VFTK(gl)ELDQWIEQLNECK_
PPP2CA Ubiquitylation K21 -1.370 _ELDQWVEQLNECK(gl)QLNENQVR_
PPP2CA Ubiquitylation K21 -1.106 _ELDQWIEQLNECK(gl)QLSESQVK_
PPP2CA Ubiquitylation K29 0.211 0.122 _QLSESQVK(gl)SLCEK_
PPP2CA Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CA Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CA Ubiquitylation K41 -0.049 0.003 _EILTK(gl)ESNVQEVR_
PPP2CA Ubiquitylation K74 -0.316 -0.316 _IGGK(gl)SPDTNYLFMGDYVDR_
RPS6 Ubiquitylation K58 2.088 1.670 _ISGGNDK(gl)QGFPMK_
RPS6 Phosphorylation S235 2.968 _LS(ph)SLRAS(ph)TSK_
RPS6 Phosphorylation S236 2.333 3.174 _LSS(ph)LRAS(ph)TSK_
RPS6 Phosphorylation S240 2.384 2.672 _LSSLRAS(ph)TSK_
RPS6 Phosphorylation T241 3.252 3.164 _LSS(ph)LRAST(ph)SK_
RPS6KB1 Ubiquitylation K99 -0.316 _VLGK(gl)GGYGK_
RPS6KB1 Phosphorylation S447 -0.525 -0.458 _TPVS(ph)PVKFSPGDFWGR_


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