bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: EIF2S2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2S2 2 10.830 -2.220 4.160 1.238 -0.784 0.387 0.537
EIF2S2 2 10.830 -2.220 4.160 -0.289

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2S2 Ubiquitylation K293 -0.051 0.495 _SPDTILQK(gl)DTR_
EIF2S2 Ubiquitylation K324 0.924 0.471 _TGFQAVTGK(gl)R_
EIF2S2 Phosphorylation S2 0.392 0.407 _(ac)S(ph)GDEM(ox)IFDPTM(ox)SKK_
EIF2S2 Phosphorylation S105 0.614 0.180 _DLKIES(ph)DVQEPTEPEDDLDIMLGNK_
EIF2S2 Phosphorylation T111 0.393 -0.207 _IESDVQEPT(ph)EPEDDLDIMLGNKK_
EIF2S2 Ubiquitylation K190 -1.188 _EK(gl)NPDMVAGEK_
EIF2S2 Ubiquitylation K199 0.815 _EKNPDMVAGEK(gl)R_
EIF2S2 Ubiquitylation K265 1.379 _FQQK(gl)QIENVLR_
EIF2S2 Ubiquitylation K276 4.065 _YIK(gl)EYVTCHTCR_

Background Information for EIF2S2:


Pubmed-EIF2S2 »
Uniprot-EIF2S2 »
Biogrid-EIF2S2 »
ProteomicsDB-EIF2S2 »

Tumorportal-EIF2S2 »
COSMIC-EIF2S2 »
GenomeRNAi-EIF2S2 »
Genecards-EIF2S2


Protein-protein Interactions for EIF2S2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait COPS7A Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC1;RP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF2S2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2S2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Transl_init_fac_IF2/IF5 IPR002735 0.08
Category members Transl_init_fac_IF2/IF5_N IPR016189 0.08
Category members Transl_init_fac_IF2/IF5_Zn-bd IPR016190 0.08


Protein complexes (CORUM database) featuring EIF2S2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5183 DNA-PK-Ku-eIF2-NF90-NF45 complex Database 0.83


Categories featuring EIF2S2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0008135 translation factor activity, nucleic acid binding Database 0.53
Category members GO Category GO:0005850 eukaryotic translation initiation factor 2 complex Database 0.46
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members Pathway Pathway_1050 BIOCARTA_RNA_PATHWAY 0 0.21
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members GO Category GO:0002176 male germ cell proliferation Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


.

© Copyright Svejstrup Laboratory 2015