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Query: EIF2S1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF2S1 0 2.182 -0.440 -0.030 0.648 0.346 0.497

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF2S1 Ubiquitylation K101 -0.331 0.258 _CEDK(gl)FTK_
EIF2S1 Ubiquitylation K106 0.463 0.148 _SK(gl)TVYSILR_
EIF2S1 Ubiquitylation K87 -0.040 _GYIDLSK(gl)R_
EIF2S1 Ubiquitylation K190 -1.695 _LTPQAVK(gl)IR_
EIF2S1 Ubiquitylation K226 -0.401 -2.300 _AGLNCSTENMPIK(gl)INLIAPPR_

Background Information for EIF2S1:


Pubmed-EIF2S1 »
Uniprot-EIF2S1 »
Biogrid-EIF2S1 »
ProteomicsDB-EIF2S1 »

Tumorportal-EIF2S1 »
COSMIC-EIF2S1 »
GenomeRNAi-EIF2S1 »
Genecards-EIF2S1


Protein-protein Interactions for EIF2S1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF2S2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF2S1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members Rbsml_prot_S1_RNA-bd_dom IPR003029 0.15
Category members S1_dom IPR022967 0.15


Protein complexes (CORUM database) featuring EIF2S1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5183 DNA-PK-Ku-eIF2-NF90-NF45 complex Database 0.83


Categories featuring EIF2S1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0010494 cytoplasmic stress granule Database 1.32
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members Pathway Pathway_392 REACTOME_PERK_REGULATED_GENE_EXPRESSION 0 0.64
Category members GO Category GO:0005850 eukaryotic translation initiation factor 2 complex Database 0.46
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0043022 ribosome binding Database 0.33
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_964 BIOCARTA_CHEMICAL_PATHWAY 0 0.24
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members Pathway Pathway_1174 BIOCARTA_EIF2_PATHWAY 0 0.22
Category members Pathway Pathway_1050 BIOCARTA_RNA_PATHWAY 0 0.21
Category members GO Category GO:0005844 polysome Database 0.09
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members GO Category GO:0005851 eukaryotic translation initiation factor 2B complex Database 0
Category members GO Category GO:0043558 regulation of translational initiation in response to stress Database 0


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