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Query: PDK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDK2 0 -0.374 0.920 -0.730

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PDK2 Ubiquitylation K376 -0.374 _LPVYNK(gl)SAWR_

Background Information for PDK2:


Pubmed-PDK2 »
Uniprot-PDK2 »
Biogrid-PDK2 »
ProteomicsDB-PDK2 »

Tumorportal-PDK2 »
COSMIC-PDK2 »
GenomeRNAi-PDK2 »
Genecards-PDK2


Protein-protein Interactions for PDK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HDAC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait PDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACAD9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FECH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDHB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAT5A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SYT12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PDK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HATPase_C IPR003594 1.07
Category members Sig_transdc_His_kinase_core IPR005467 0.2
Category members BCDHK/PDK_N IPR018955 0.2


Protein complexes (CORUM database) featuring PDK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PDK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0006885 regulation of pH Database 0.55
Category members GO Category GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity Database 0.48
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0010906 regulation of glucose metabolic process Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0010565 regulation of cellular ketone metabolic process Database 0.08
Category members Pathway Pathway_14 REACTOME_PYRUVATE_METABOLISM 0 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0006090 pyruvate metabolic process Database 0.04
Category members Pathway Pathway_15 REACTOME_REGULATION_OF_PYRUVATE_DEHYDROGENASE_PDH_COMPLEX 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_553 BIOCARTA_PTEN_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members GO Category GO:0005967 mitochondrial pyruvate dehydrogenase complex Database 0
Category members GO Category GO:0006111 regulation of gluconeogenesis Database 0
Category members GO Category GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate Database 0
Category members GO Category GO:0031670 cellular response to nutrient Database 0
Category members GO Category GO:0034614 cellular response to reactive oxygen species Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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