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Query: PPP2CA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP2CA 0 2.690 0.160 -0.540 0.650 1.189
PPP2CA 0 2.690 0.160 -0.540 0.194 0.044 0.215

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP2CA Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CA Ubiquitylation K36 -0.455 0.187 _AK(gl)EILTK_
PPP2CA Ubiquitylation K29 0.211 0.122 _QLSESQVK(gl)SLCEK_
PPP2CA Ubiquitylation K41 -0.049 0.003 _EILTK(gl)ESNVQEVR_
PPP2CA Ubiquitylation K4 -0.450 -0.016 _(ac)M(ox)DEK(gl)VFTK_
PPP2CA Ubiquitylation K74 -0.316 -0.316 _IGGK(gl)SPDTNYLFMGDYVDR_
PPP2CA Ubiquitylation K4 -0.788 -0.378 _(ac)MDDK(gl)AFTK_
PPP2CA Ubiquitylation K21 -1.370 _ELDQWVEQLNECK(gl)QLNENQVR_
PPP2CA Ubiquitylation K8 -0.522 _VFTK(gl)ELDQWIEQLNECK_
PPP2CA Ubiquitylation K21 -1.106 _ELDQWIEQLNECK(gl)QLSESQVK_

Background Information for PPP2CA:


Pubmed-PPP2CA »
Uniprot-PPP2CA »
Biogrid-PPP2CA »
ProteomicsDB-PPP2CA »

Tumorportal-PPP2CA »
COSMIC-PPP2CA »
GenomeRNAi-PPP2CA »
Genecards-PPP2CA


Protein-protein Interactions for PPP2CA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait FAM40A Cat. description Hein, Mann, Cell 2015
Category members IP bait FGFR1OP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait IGBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NHSL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R2D Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R3A Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R5D Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SIKE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait STRN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDCA4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EEF1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC8A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LCMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRRC56 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPME1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFWD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERTAD4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SGOL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBCCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINAG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRAF3IP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR86 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFC3H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF331 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF517 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF550 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF764 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP2CA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser/Thr-sp_prot-phosphatase IPR006186 0.88
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring PPP2CA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1543 PPP2CA-PPP2R1A complex Database 0.15
Category members Corum 5876 PPP2R1A-PPP2R1B-PPP2CA-PPME1-EIF4A1 complex Database 0.08
Category members Corum 1544 PPP2CA-PPP2R1A-PPP2R3A complex Database 0


Categories featuring PPP2CA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_770 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members Pathway Pathway_865 PID_ATR_PATHWAY 0 3.46
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_807 REACTOME_SIGNALING_BY_WNT 0 2.74
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_416 PID_P53_REGULATION_PATHWAY 0 2.29
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members Pathway Pathway_579 PID_ERBB1_DOWNSTREAM_PATHWAY 0 1.97
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_265 REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 0 1.42
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members Pathway Pathway_1257 REACTOME_CTNNB1_PHOSPHORYLATION_CASCADE 0 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_561 PID_PDGFRB_PATHWAY 0 1.18
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members Pathway Pathway_936 REACTOME_CTLA4_INHIBITORY_SIGNALING 0 0.77
Category members Pathway Pathway_662 PID_IL8_CXCR2_PATHWAY 0 0.62
Category members Pathway Pathway_123 BIOCARTA_CHREBP2_PATHWAY 0 0.61
Category members Pathway Pathway_254 REACTOME_SIGNALING_BY_FGFR 0 0.61
Category members Pathway Pathway_628 BIOCARTA_GSK3_PATHWAY 0 0.6
Category members GO Category GO:0007498 mesoderm development Database 0.58
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members Pathway Pathway_305 REACTOME_DARPP_32_EVENTS 0 0.47
Category members Pathway Pathway_542 BIOCARTA_AKT_PATHWAY 0 0.45
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0031952 regulation of protein autophosphorylation Database 0.39
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_720 REACTOME_PLATELET_SENSITIZATION_BY_LDL 0 0.29
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members Pathway Pathway_260 REACTOME_OPIOID_SIGNALLING 0 0.28
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members GO Category GO:0007084 mitotic nuclear envelope reassembly Database 0.24
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_406 PID_RB_1PATHWAY 0 0.21
Category members Pathway Pathway_826 REACTOME_ACTIVATED_TLR4_SIGNALLING 0 0.21
Category members Pathway Pathway_1001 REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES 0 0.2
Category members Pathway Pathway_1141 BIOCARTA_P35ALZHEIMERS_PATHWAY 0 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members Pathway Pathway_858 PID_MYC_PATHWAY 0 0.17
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members Pathway Pathway_1028 PID_PLK1_PATHWAY 0 0.16
Category members GO Category GO:0006275 regulation of DNA replication Database 0.14
Category members Pathway Pathway_893 KEGG_TGF_BETA_SIGNALING_PATHWAY 0 0.14
Category members Pathway Pathway_797 REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 0 0.12
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members Pathway Pathway_312 REACTOME_INHIBITION_OF_REPLICATION_INITIATION_OF_DAMAGED_DNA_BY_RB1_E2F1 0 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members Pathway Pathway_813 REACTOME_TRIF_MEDIATED_TLR3_SIGNALING 0 0.11
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members Pathway Pathway_810 REACTOME_SPRY_REGULATION_OF_FGF_SIGNALING 0 0.09
Category members Pathway Pathway_941 BIOCARTA_WNT_PATHWAY 0 0.08
Category members Pathway Pathway_285 REACTOME_PLATELET_HOMEOSTASIS 0 0.08
Category members GO Category GO:0030111 regulation of Wnt signaling pathway Database 0.08
Category members Pathway Pathway_620 REACTOME_COSTIMULATION_BY_THE_CD28_FAMILY 0 0.06
Category members Pathway Pathway_814 REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 0 0.05
Category members Pathway Pathway_996 REACTOME_MAP_KINASE_ACTIVATION_IN_TLR_CASCADE 0 0.05
Category members GO Category GO:0001932 regulation of protein phosphorylation Database 0.04
Category members Pathway Pathway_834 REACTOME_NFKB_AND_MAP_KINASES_ACTIVATION_MEDIATED_BY_TLR4_SIGNALING_REPERTOIRE 0 0.04
Category members GO Category GO:0019932 second-messenger-mediated signaling Database 0.04
Category members Pathway Pathway_791 REACTOME_G1_PHASE 0 0.02
Category members GO Category GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein Database 0.02
Category members GO Category GO:0007126 meiosis Database 0.01
Category members Pathway Pathway_1048 BIOCARTA_KERATINOCYTE_PATHWAY 0 0
Category members Pathway Pathway_1063 REACTOME_ERK_MAPK_TARGETS 0 0
Category members Pathway Pathway_1064 REACTOME_ERKS_ARE_INACTIVATED 0 0
Category members Pathway Pathway_1065 REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION 0 0
Category members Pathway Pathway_1072 BIOCARTA_ERK_PATHWAY 0 0
Category members Pathway Pathway_1153 BIOCARTA_AKAPCENTROSOME_PATHWAY 0 0
Category members Pathway Pathway_290 WNT_SIGNALING 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_637 BIOCARTA_CTCF_PATHWAY 0 0
Category members Pathway Pathway_676 BIOCARTA_CK1_PATHWAY 0 0
Category members Pathway Pathway_783 REACTOME_NEGATIVE_REGULATION_OF_FGFR_SIGNALING 0 0
Category members Pathway Pathway_879 BIOCARTA_AKAP95_PATHWAY 0 0
Category members GO Category GO:0000159 protein phosphatase type 2A complex Database 0
Category members GO Category GO:0000188 inactivation of MAPK activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0006672 ceramide metabolic process Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0010469 regulation of receptor activity Database 0
Category members GO Category GO:0010719 negative regulation of epithelial to mesenchymal transition Database 0
Category members GO Category GO:0030155 regulation of cell adhesion Database 0
Category members GO Category GO:0040008 regulation of growth Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0070208 protein heterotrimerization Database 0


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