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Query: EIF4E

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF4E 1 4.947 -2.250 4.200 0.590 0.156
EIF4E 1 4.947 -2.250 4.200 0.369

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF4E Ubiquitylation K147 -0.433 0.065 _WLITLNK(gl)QQR_

Background Information for EIF4E:


Pubmed-EIF4E »
Uniprot-EIF4E »
Biogrid-EIF4E »
ProteomicsDB-EIF4E »

Tumorportal-EIF4E »
COSMIC-EIF4E »
GenomeRNAi-EIF4E »
Genecards-EIF4E


Protein-protein Interactions for EIF4E
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF4E Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF4E
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members TIF_eIF_4E IPR001040 0
Category members TIF_eIF4e-like_dom IPR023398 0


Protein complexes (CORUM database) featuring EIF4E
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5253 MNK1-eIF4F complex Database 0


Categories featuring EIF4E
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members Pathway Pathway_886 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 0 5.93
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_724 PID_MTOR_4PATHWAY 0 2
Category members GO Category GO:0010494 cytoplasmic stress granule Database 1.32
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members Pathway Pathway_1274 BIOCARTA_EIF_PATHWAY 0 0.78
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members Pathway Pathway_402 BIOCARTA_SARS_PATHWAY 0 0.64
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0030324 lung development Database 0.39
Category members Pathway Pathway_983 ST_P38_MAPK_PATHWAY 0 0.34
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_508 BIOCARTA_IGF1MTOR_PATHWAY 0 0.25
Category members Pathway Pathway_44 KEGG_INSULIN_SIGNALING_PATHWAY 0 0.21
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0016442 RISC complex Database 0.18
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0016281 eukaryotic translation initiation factor 4F complex Database 0.08
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members GO Category GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening Database 0.06
Category members Pathway Pathway_1005 ST_ERK1_ERK2_MAPK_PATHWAY 0 0.06
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_302 REACTOME_PKB_MEDIATED_EVENTS 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_422 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY 0 0
Category members Pathway Pathway_552 BIOCARTA_MTOR_PATHWAY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_638 BIOCARTA_EIF4_PATHWAY 0 0
Category members Pathway Pathway_839 REACTOME_MTORC1_MEDIATED_SIGNALLING 0 0
Category members Pathway Pathway_841 REACTOME_DEADENYLATION_OF_MRNA 0 0
Category members GO Category GO:0000339 RNA cap binding Database 0
Category members GO Category GO:0005845 mRNA cap binding complex Database 0
Category members GO Category GO:0006417 regulation of translation Database 0
Category members GO Category GO:0033391 chromatoid body Database 0


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