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KEGG_MTOR_SIGNALING_PATHWAY
(Pathway_554)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
RPS6 5 -1.590 2.890 0.202 -0.347 -0.009 -0.153 0.152
AKT3 2 0.580 -0.030 -0.194
AKT3 2 0.580 -0.030
TSC2 1 0.810 -0.710
TSC2 1 0.810 -0.710 -0.715
PIK3R2 1 2.740 -1.180 0.269 0.348
RHEB 1 2.630 -1.320 0.991 -0.417
EIF4E 1 -2.250 4.200 0.590 0.156
EIF4E 1 -2.250 4.200 0.369
RICTOR 1 -0.330 0.710
RICTOR 1 -0.270 0.570
RPS6KA3 1 -1.550 2.890
EIF4EBP1 1 2.050 -1.320
PIK3CB 0 -1.390 2.350
PIK3CB 0 -0.710 1.450
EIF4B 0 -0.020 0.470 -0.169 -0.233 -0.211 -0.927 -0.212
RPS6KA6 0 -1.250 1.770
HIF1A 0 -0.480 0.400
MAPK3 0
AKT2 0 -1.420 2.210 -0.194
RPS6KB1 0 0.850 -0.600
PIK3R3 0 -0.140 -0.480
PIK3R3 0 -0.140 -0.480 -0.441 0.147
RPS6KA1 0 -0.160 -0.660
RPS6KA1 0 -0.160 -0.660
STK11 0
PIK3CA 0
PRKAA1 0 0.910 0.060
EIF4E2 0 0.840 -0.580 -0.233 -0.963
CAB39 0 -0.920 0.670
PDPK1 0 0.050 -0.440
RPTOR 0 0.520 -1.030 0.623 0.466
AKT1 0 -0.050 0.700
AKT1 0 0.860 -0.040
PIK3R1 0 1.910 -1.220 -0.441 0.147
BRAF 0
PRKAA2 0 -0.030 -0.350
PRKAA2 0 -0.030 -0.350
TSC1 0 1.100 -0.150
MLST8 0 -0.170 0.220
DDIT4 0 0.750 -0.520
RPS6KB2 0 -1.260 2.030
EIF4E1B 0 1.610 -1.080 0.590 0.156
ULK1 0 0.740 -0.520
MTOR 0 -0.680 0.150 0.757 0.074 0.101
STRADA 0

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AKT1 Phosphorylation S124 0.252 0.311 _SGS(ph)PSDNSGAEEMEVSLAKPK_
AKT1 Phosphorylation S126 -0.241 _SGSPS(ph)DNSGAEEM(ox)EVSLAK_
AKT1 Ubiquitylation K301 0.988 _EGIK(gl)DGATMK_
AKT2 Ubiquitylation K14 0.306 0.070 _EGWLHK(gl)R_
AKT2 Ubiquitylation K111 1.082 _AIQMVANSLK(gl)QR_
AKT2 Ubiquitylation K160 0.251 _LLGK(gl)GTFGK_
AKT2 Phosphorylation T451 -0.091 -0.612 _YFDDEFTAQSITIT(ph)PPDRYDSLGLLELDQR_
AKT2 Phosphorylation Y456 -0.265 _YFDDEFTAQSITITPPDRY(ph)DSLGLLELDQR_
AKT3 Ubiquitylation K14 0.306 0.070 _EGWLHK(gl)R_
AKT3 Ubiquitylation K14 4.941 5.277 _EGWVQK(gl)R_
AKT3 Ubiquitylation K111 1.082 _AIQMVANSLK(gl)QR_
AKT3 Phosphorylation S120 1.097 _MNCS(ph)PTSQIDNIGEEEMDASTTHHK_
AKT3 Ubiquitylation K160 0.251 _LLGK(gl)GTFGK_
AKT3 Phosphorylation T451 -0.091 -0.612 _YFDDEFTAQSITIT(ph)PPDRYDSLGLLELDQR_
AKT3 Phosphorylation Y456 -0.265 _YFDDEFTAQSITITPPDRY(ph)DSLGLLELDQR_
BRAF Phosphorylation S151 -0.685 -0.629 _SNPKS(ph)PQKPIVR_
BRAF Phosphorylation S363 -0.023 -0.241 _S(ph)SSAPNVHINTIEPVNIDDLIR_
BRAF Phosphorylation S365 -0.286 0.012 _SSS(ph)APNVHINTIEPVNIDDLIR_
BRAF Phosphorylation S399 -0.890 -0.527 _GDGGSTTGLS(ph)ATPPASLPGSLTNVK_
BRAF Phosphorylation T401 -0.525 _GDGGSTTGLSAT(ph)PPASLPGSLTNVK_
BRAF Phosphorylation S446 0.246 0.349 _RDS(ph)SDDWEIPDGQITVGQR_
BRAF Phosphorylation S447 0.579 0.623 _RDSS(ph)DDWEIPDGQITVGQR_
BRAF Phosphorylation S729 0.208 0.219 _SAS(ph)EPSLNR_
CAB39 Ubiquitylation K20 0.992 _NLK(gl)ESMAVLEK_
DDIT4 Ubiquitylation K129 -0.435 -0.920 _LLM(ox)PSQLVSQVGK(gl)ELLR_
EIF4B Phosphorylation S93 -0.425 -0.444 _S(ph)PPYTAFLGNLPYDVTEESIKEFFR_
EIF4B Phosphorylation S207 -0.235 0.162 _ARPATDS(ph)FDDYPPR_
EIF4B Phosphorylation S283 0.453 0.543 _AFGS(ph)GYR_
EIF4B Ubiquitylation K365 0.071 _AASIFGGAK(gl)PVDTAAR_
EIF4B Phosphorylation S464 -0.446 0.097 _EEDCHS(ph)PTSKPPKPDQPLK_
EIF4E Ubiquitylation K147 -0.433 0.065 _WLITLNK(gl)QQR_
EIF4E1B Ubiquitylation K147 -0.433 0.065 _WLITLNK(gl)QQR_
EIF4EBP1 Phosphorylation Y34 -1.060 _RVVLGDGVQLPPGDY(ph)STTPGGTLFS(ph)TTPGGTR_
EIF4EBP1 Phosphorylation S35 -0.849 _RVVLGDGVQLPPGDYS(ph)TTPGGTLFS(ph)TTPGGTR_
EIF4EBP1 Phosphorylation T37 -0.768 -0.583 _RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR_
EIF4EBP1 Phosphorylation T41 -3.655 -0.903 _RVVLGDGVQLPPGDYST(ph)TPGGT(ph)LFSTTPGGTR_
EIF4EBP1 Phosphorylation S44 -0.796 _VVLGDGVQLPPGDYSTTPGGTLFS(ph)T(ph)TPGGTR_
EIF4EBP1 Phosphorylation T45 -0.727 _VVLGDGVQLPPGDYSTTPGGTLFS(ph)T(ph)TPGGTR_
EIF4EBP1 Phosphorylation T46 -0.890 -0.817 _RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR_
EIF4EBP1 Phosphorylation S65 0.522 0.478 _NS(ph)PVTKT(ph)PPR_
EIF4EBP1 Phosphorylation T68 -1.621 -2.402 _NS(ph)PVT(ph)KTPPRDLPTIPGVTSPSSDEPPMEASQSHLR_
EIF4EBP1 Ubiquitylation K69 -1.171 -1.547 _NSPVTK(gl)TPPR_
EIF4EBP1 Phosphorylation T70 -0.702 -0.017 _NSPVTKT(ph)PPR_
EIF4EBP1 Phosphorylation T77 -1.921 -1.898 _TPPRDLPT(ph)IPGVTSPSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation T82 1.253 _DLPTIPGVT(ph)SPSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation S83 1.211 0.339 _DLPTIPGVTS(ph)PSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation S96 -1.541 _DLPTIPGVTSPSSDEPPMEASQS(ph)HLRNSPEDK_
EIF4EBP1 Phosphorylation S101 -1.900 -1.976 _DLPTIPGVTSPSSDEPPMEASQSHLRNS(ph)PEDK_
HIF1A Ubiquitylation K10 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K11 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K173 -0.662 _MK(gl)CTLTSR_
HIF1A Ubiquitylation K186 -0.590 _TMNIK(gl)SATWK_
HIF1A Ubiquitylation K252 -0.784 _HSLDM(ox)K(gl)FSYCDER_
HIF1A Ubiquitylation K371 -0.508 _PVESSDMK(gl)MTQLFTK_
HIF1A Ubiquitylation K378 -0.077 _MTQLFTK(gl)VESEDTSSLFDK_
HIF1A Ubiquitylation K390 -0.348 _VESEDTSSLFDK(gl)LKK_
HIF1A Ubiquitylation K392 -0.546 _VESEDTSSLFDKLK(gl)_
HIF1A Ubiquitylation K393 -0.451 _VESEDTSSLFDKLKK(gl)_
HIF1A Ubiquitylation K710 -1.696 _TTVPEEELNPK(gl)ILALQNAQR_
MAPK3 Phosphorylation Y204 -0.807 -2.487 _IADPEHDHTGFLTEY(ph)VATR_
MAPK3 Ubiquitylation K289 -0.608 _NYLQSLPSKTK(gl)_
MLST8 Phosphorylation T3 -0.481 _(ac)MNT(ph)SPGTVGSDPVILATAGYDHTVR_
MLST8 Ubiquitylation K245 -0.114 0.462 _FSPDSTLLATCSADQTCK(gl)IWR_
MTOR Ubiquitylation K309 -0.762 0.065 _DLMGFGTK(gl)PR_
MTOR Ubiquitylation K1257 -1.167 -0.901 _SGQGDALASGPVETGPMKK(gl)_
MTOR Ubiquitylation K1395 -1.255 _AYAK(gl)ALHYK_
MTOR Ubiquitylation K2066 -1.004 _GPQTLK(gl)ETSFNQAYGR_
MTOR Ubiquitylation K2166 -1.304 _IQSIAPSLQVITSK(gl)QRPR_
MTOR Phosphorylation T2471 0.329 _KT(ph)GTTVPESIHSFIGDGLVKPEALNK_
PDPK1 Phosphorylation S241 0.358 0.361 _ANS(ph)FVGTAQYVSPELLTEK_
PDPK1 Ubiquitylation K257 0.571 -0.234 _ANSFVGTAQYVSPELLTEK(gl)SACK_
PIK3CA Ubiquitylation K864 0.390 0.588 _NSHTIM(ox)QIQCK(gl)GGLK_
PIK3CA Ubiquitylation K868 0.204 0.651 _NSHTIM(ox)QIQCKGGLK(gl)_
PIK3CA Ubiquitylation K974 -0.273 _GAQECTK(gl)TREFER_
PIK3CB Ubiquitylation K1044 0.990 _SEEEALKQFKQK(gl)_
PIK3R2 Phosphorylation S262 -2.237 _APPPPS(ph)SPPPGGAPDGSEPSPDFPALLVEK_
PIK3R2 Phosphorylation S263 -2.237 _APPPPS(ph)SPPPGGAPDGSEPSPDFPALLVEK_
PIK3R2 Ubiquitylation K500 -0.189 _IFEEQGQTQEK(gl)CSK_
PIK3R2 Ubiquitylation K541 -0.609 _TK(gl)LEQQLR_
PIK3R2 Ubiquitylation K564 -0.431 -1.022 _MNSLK(gl)PDLMQLR_
PIK3R3 Ubiquitylation K226 -0.376 _YQQDQLVKEDNIDAVGKK(gl)_
PIK3R3 Ubiquitylation K320 0.385 _LGEIHDSK(gl)MR_
PRKAA1 Ubiquitylation K271 -0.536 _ATIK(gl)DIR_
PRKAA1 Ubiquitylation K396 -0.419 _HTLDELNPQK(gl)SK_
PRKAA1 Ubiquitylation K485 -1.326 -1.554 _SIDDEITEAK(gl)SGTATPQR_
PRKAA2 Ubiquitylation K271 -0.536 _ATIK(gl)DIR_
PRKAA2 Phosphorylation S377 -0.020 _MPPLIADS(ph)PK_
RHEB Ubiquitylation K121 -0.852 _VQIPIMLVGNKK(gl)_
RICTOR Phosphorylation S21 -0.279 0.249 _NDS(ph)GEENVPLDLTR_
RICTOR Ubiquitylation K830 -0.874 _GYVAKQLEK(gl)_
RICTOR Phosphorylation S1284 2.625 _SNS(ph)VSLVPPGSSHTLPR_
RICTOR Phosphorylation S1302 -0.560 0.260 _RAQS(ph)LKAPSIATIK_
RICTOR Phosphorylation S1388 0.507 _ALSYAS(ph)LDKEDLLSPINQNTLQR_
RPS6 Ubiquitylation K58 2.088 1.670 _ISGGNDK(gl)QGFPMK_
RPS6 Phosphorylation S235 2.968 _LS(ph)SLRAS(ph)TSK_
RPS6 Phosphorylation S236 2.333 3.174 _LSS(ph)LRAS(ph)TSK_
RPS6 Phosphorylation S240 2.384 2.672 _LSSLRAS(ph)TSK_
RPS6 Phosphorylation T241 3.252 3.164 _LSS(ph)LRAST(ph)SK_
RPS6KA1 Phosphorylation S227 0.363 0.496 _AYS(ph)FCGTVEYM(ox)APEVVNR_
RPS6KA1 Phosphorylation T231 0.315 _KAYSFCGT(ph)VEYMAPEVVNR_
RPS6KA1 Ubiquitylation K316 -1.156 _LGSGPDGAEEIK(gl)R_
RPS6KA1 Phosphorylation T359 -0.149 -0.339 _T(ph)PKDSPGIPPSAGAHQLFR_
RPS6KA1 Phosphorylation S363 -0.711 -0.697 _TPKDS(ph)PGIPPSAGAHQLFR_
RPS6KA1 Ubiquitylation K566 -0.152 _ICDFGFAK(gl)QLR_
RPS6KA3 Phosphorylation S227 0.363 0.496 _AYS(ph)FCGTVEYM(ox)APEVVNR_
RPS6KA3 Phosphorylation T231 0.315 _KAYSFCGT(ph)VEYMAPEVVNR_
RPS6KA3 Ubiquitylation K322 -0.076 -0.376 _LGAGPDGVEEIK(gl)R_
RPS6KA3 Phosphorylation T365 -0.892 -1.003 _T(ph)PKDSPGIPPSANAHQLFR_
RPS6KA3 Phosphorylation S369 -0.621 -0.862 _TPKDS(ph)PGIPPSANAHQLFR_
RPS6KA3 Ubiquitylation K566 -0.152 _ICDFGFAK(gl)QLR_
RPS6KA3 Phosphorylation S715 -0.923 -0.880 _NQS(ph)PVLEPVGR_
RPS6KA6 Phosphorylation S227 0.363 0.496 _AYS(ph)FCGTVEYM(ox)APEVVNR_
RPS6KA6 Phosphorylation T231 0.315 _KAYSFCGT(ph)VEYMAPEVVNR_
RPS6KA6 Ubiquitylation K566 -0.152 _ICDFGFAK(gl)QLR_
RPS6KB1 Ubiquitylation K99 -0.316 _VLGK(gl)GGYGK_
RPS6KB1 Phosphorylation S447 -0.525 -0.458 _TPVS(ph)PVKFSPGDFWGR_
RPS6KB2 Ubiquitylation K99 -0.316 _VLGK(gl)GGYGK_
RPTOR Phosphorylation S722 0.393 1.196 _SVSS(ph)YGNIR_
RPTOR Phosphorylation T857 -0.348 _VLDTSSLT(ph)QSAPAS(ph)PTNK_
RPTOR Phosphorylation S859 -0.462 -0.346 _VLDTSSLTQS(ph)APASPT(ph)NK_
RPTOR Phosphorylation S863 -0.208 -0.001 _VLDTSSLTQS(ph)APAS(ph)PTNK_
RPTOR Phosphorylation T865 -0.317 _VLDTSSLTQS(ph)APASPT(ph)NK_
RPTOR Phosphorylation S877 -0.114 -0.074 _GVHIHQAGGS(ph)PPASSTSSSSLTNDVAK_
RPTOR Ubiquitylation K1008 -0.329 _QAQQVIQK(gl)GITR_
STK11 Phosphorylation S31 0.437 0.073 _IDS(ph)TEVIYQPR_
STK11 Phosphorylation T32 1.256 0.248 _IDS(ph)TEVIYQPR_
STRADA Ubiquitylation K7 -0.518 _(ac)SFLVSK(gl)PER_
TSC1 Phosphorylation S505 0.141 0.350 _GGFDS(ph)PFYR_
TSC2 Ubiquitylation K3 -1.397 _(ac)AK(gl)PTSKDSGLK_
TSC2 Ubiquitylation K14 -1.297 _DSGLKEK(gl)FK_
TSC2 Ubiquitylation K69 0.051 _MIGQICEVAK(gl)TK_
TSC2 Ubiquitylation K71 -0.157 _MIGQICEVAKTK(gl)_
TSC2 Ubiquitylation K258 -0.278 _ELCEPCWK(gl)LMR_
TSC2 Ubiquitylation K634 1.610 _LGLPNK(gl)DGVVR_
TSC2 Phosphorylation S950 -0.152 -0.529 _STS(ph)LNERPK_
TSC2 Phosphorylation S1064 -0.927 _SLLGLDSGELQSGPESSSS(ph)PGVHVR_
TSC2 Phosphorylation S1248 -0.604 _SNTDSAVVMEEGS(ph)PGEVPVLVEPPGLEDVEAALGMDRR_
TSC2 Phosphorylation S1329 -0.120 _S(ph)SSSPELQTLQDILGDPGDK_
TSC2 Phosphorylation S1331 -0.262 _SSS(ph)SPELQTLQDILGDPGDKADVGR_
TSC2 Phosphorylation S1332 -0.063 _SSSS(ph)PELQTLQDILGDPGDK_
TSC2 Phosphorylation S1355 0.174 0.351 _ADVGRLS(ph)PEVK_
TSC2 Phosphorylation S1362 0.859 _S(ph)QSGTLDGESAAWSASGEDSR_
TSC2 Phosphorylation S1364 0.522 0.550 _SQS(ph)GTLDGESAAWSASGEDSR_
TSC2 Phosphorylation T1366 0.137 _SQSGT(ph)LDGESAAWSASGEDSR_
TSC2 Phosphorylation S1396 0.498 _S(ph)PSGLRPR_
TSC2 Phosphorylation S1743 0.596 _RLISS(ph)VEDFTEFV_
ULK1 Phosphorylation S450 -0.237 -0.173 _NLQS(ph)PTQFQTPR_
ULK1 Phosphorylation T468 -0.247 0.456 _SGST(ph)SPLGFAR_
ULK1 Phosphorylation S469 0.035 0.470 _SGSTS(ph)PLGFAR_
ULK1 Phosphorylation S623 -0.793 -0.874 _NPLPPILGS(ph)PTK_
ULK1 Phosphorylation T625 -0.547 -0.776 _NPLPPILGSPT(ph)K_
ULK1 Phosphorylation T636 0.087 _T(ph)PSSQNLLALLAR_
ULK1 Phosphorylation S638 -0.154 0.598 _TPS(ph)SQNLLALLAR_


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