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Query: HIF1A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HIF1A 0 0.323 -0.480 0.400

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HIF1A Ubiquitylation K378 -0.077 _MTQLFTK(gl)VESEDTSSLFDK_
HIF1A Ubiquitylation K390 -0.348 _VESEDTSSLFDK(gl)LKK_
HIF1A Ubiquitylation K393 -0.451 _VESEDTSSLFDKLKK(gl)_
HIF1A Ubiquitylation K371 -0.508 _PVESSDMK(gl)MTQLFTK_
HIF1A Ubiquitylation K392 -0.546 _VESEDTSSLFDKLK(gl)_
HIF1A Ubiquitylation K186 -0.590 _TMNIK(gl)SATWK_
HIF1A Ubiquitylation K173 -0.662 _MK(gl)CTLTSR_
HIF1A Ubiquitylation K252 -0.784 _HSLDM(ox)K(gl)FSYCDER_
HIF1A Ubiquitylation K10 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K11 -1.686 _(ac)MEGAGGANDK(gl)K_
HIF1A Ubiquitylation K710 -1.696 _TTVPEEELNPK(gl)ILALQNAQR_

Background Information for HIF1A:


Pubmed-HIF1A »
Uniprot-HIF1A »
Biogrid-HIF1A »
ProteomicsDB-HIF1A »

Tumorportal-HIF1A »
COSMIC-HIF1A »
GenomeRNAi-HIF1A »
Genecards-HIF1A


Protein-protein Interactions for HIF1A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HIF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait ARNT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HIF1A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PAS_fold_3 IPR013655 0.69
Category members bHLH_dom IPR011598 0.32
Category members PAS_fold IPR013767 0.27
Category members PAC IPR001610 0.23
Category members PAS IPR000014 0.23
Category members HIF_alpha_subunit IPR021537 0.04
Category members HIF-1_TAD_C IPR014887 0


Protein complexes (CORUM database) featuring HIF1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5382 ARNT-HIF1A complex Database 0.04
Category members Corum 298 VEGF transcriptional complex Database 0
Category members Corum 5273 VHL-TBP1-HIF1A complex Database 0
Category members Corum 5276 HIF1A-OS9-EGLN1 complex Database 0
Category members Corum 5277 HIF1A-OS9-EGLN3 complex Database 0


Categories featuring HIF1A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members Pathway Pathway_753 REACTOME_REGULATION_OF_HYPOXIA_INDUCIBLE_FACTOR_HIF_BY_OXYGEN 0 0.35
Category members GO Category GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development Database 0.33
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0032007 negative regulation of TOR signaling Database 0.33
Category members GO Category GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0.32
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0001944 vasculature development Database 0.24
Category members GO Category GO:0045648 positive regulation of erythrocyte differentiation Database 0.23
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_1145 BIOCARTA_EPONFKB_PATHWAY 0 0.2
Category members GO Category GO:0045766 positive regulation of angiogenesis Database 0.19
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0060574 intestinal epithelial cell maturation Database 0.18
Category members GO Category GO:0070243 regulation of thymocyte apoptotic process Database 0.18
Category members Pathway Pathway_759 BIOCARTA_P53HYPOXIA_PATHWAY 0 0.18
Category members GO Category GO:0035162 embryonic hemopoiesis Database 0.17
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0001947 heart looping Database 0.08
Category members GO Category GO:0006089 lactate metabolic process Database 0.08
Category members GO Category GO:0003208 cardiac ventricle morphogenesis Database 0.08
Category members GO Category GO:0010634 positive regulation of epithelial cell migration Database 0.08
Category members GO Category GO:0042789 mRNA transcription from RNA polymerase II promoter Database 0.07
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0042127 regulation of cell proliferation Database 0.06
Category members GO Category GO:0030502 negative regulation of bone mineralization Database 0.05
Category members GO Category GO:0042541 hemoglobin biosynthetic process Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress Database 0.03
Category members Pathway Pathway_23 KEGG_RENAL_CELL_CARCINOMA 0 0.03
Category members GO Category GO:0000989 transcription factor binding transcription factor activity Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members Pathway Pathway_821 REACTOME_OXYGEN_DEPENDENT_PROLINE_HYDROXYLATION_OF_HYPOXIA_INDUCIBLE_FACTOR_ALPHA 0 0
Category members Pathway Pathway_119 PID_HES_HEY_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members Pathway Pathway_429 BIOCARTA_VEGF_PATHWAY 0 0
Category members Pathway Pathway_431 PID_VEGFR1_PATHWAY 0 0
Category members Pathway Pathway_443 PID_AP1_PATHWAY 0 0
Category members Pathway Pathway_554 KEGG_MTOR_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_976 PID_HIF1A_PATHWAY 0 0
Category members GO Category GO:0001076 RNA polymerase II transcription factor binding transcription factor activity Database 0
Category members GO Category GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Database 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0001755 neural crest cell migration Database 0
Category members GO Category GO:0001837 epithelial to mesenchymal transition Database 0
Category members GO Category GO:0001892 embryonic placenta development Database 0
Category members GO Category GO:0001922 B-1 B cell homeostasis Database 0
Category members GO Category GO:0001938 positive regulation of endothelial cell proliferation Database 0
Category members GO Category GO:0002052 positive regulation of neuroblast proliferation Database 0
Category members GO Category GO:0002248 connective tissue replacement involved in inflammatory response wound healing Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006110 regulation of glycolysis Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006879 cellular iron ion homeostasis Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0008542 visual learning Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010575 positive regulation vascular endothelial growth factor production Database 0
Category members GO Category GO:0010870 positive regulation of receptor biosynthetic process Database 0
Category members GO Category GO:0014850 response to muscle activity Database 0
Category members GO Category GO:0019896 axon transport of mitochondrion Database 0
Category members GO Category GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0031514 motile cilium Database 0
Category members GO Category GO:0032364 oxygen homeostasis Database 0
Category members GO Category GO:0032722 positive regulation of chemokine production Database 0
Category members GO Category GO:0032909 regulation of transforming growth factor beta2 production Database 0
Category members GO Category GO:0032963 collagen metabolic process Database 0
Category members GO Category GO:0035035 histone acetyltransferase binding Database 0
Category members GO Category GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus Database 0
Category members GO Category GO:0045821 positive regulation of glycolysis Database 0
Category members GO Category GO:0045926 negative regulation of growth Database 0
Category members GO Category GO:0046716 muscle cell cellular homeostasis Database 0
Category members GO Category GO:0046886 positive regulation of hormone biosynthetic process Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0048514 blood vessel morphogenesis Database 0
Category members GO Category GO:0048546 digestive tract morphogenesis Database 0
Category members GO Category GO:0050790 regulation of catalytic activity Database 0
Category members GO Category GO:0051000 positive regulation of nitric-oxide synthase activity Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0051879 Hsp90 protein binding Database 0
Category members GO Category GO:0061298 retina vasculature development in camera-type eye Database 0
Category members GO Category GO:0061419 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia Database 0
Category members GO Category GO:0070101 positive regulation of chemokine-mediated signaling pathway Database 0
Category members GO Category GO:0070244 negative regulation of thymocyte apoptotic process Database 0
Category members GO Category GO:0071347 cellular response to interleukin-1 Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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